FCMR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0038093Biological processFc receptor signaling pathway
GO_0160006Biological processFc receptor-mediated immune complex endocytosis
GO_0043066Biological processnegative regulation of apoptotic process
GO_0050855Biological processregulation of B cell receptor signaling pathway
GO_0002455Biological processhumoral immune response mediated by circulating immunoglobulin
GO_0006968Biological processcellular defense response
GO_0002414Biological processimmunoglobulin transcytosis in epithelial cells
GO_0032588Cellular componenttrans-Golgi network membrane
GO_0031901Cellular componentearly endosome membrane
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0005765Cellular componentlysosomal membrane
GO_0004888Molecular functiontransmembrane signaling receptor activity
GO_0002172Molecular functionhigh-affinity IgM receptor activity
GO_0001790Molecular functionpolymeric immunoglobulin binding
GO_0001791Molecular functionIgM binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFCMR
Protein nameFc mu receptor
Immunoglobulin mu Fc receptor (IgM FcR) (Fas apoptotic inhibitory molecule 3) (FAIM3) (Regulator of Fas-induced apoptosis Toso)
SynonymsFAIM3
TOSO
DescriptionFUNCTION: High-affinity Fc receptor for immunoglobulin M (IgM), both secreted and membrane-bound IgM . Primarily regulates IgM transport and homeostasis. Primarily regulates IgM transport and homeostasis. In lymphoid cells, enables exocytosis of membrane-bound IgM on the plasma membrane as well as endocytosis of IgM-antigen complexes toward lysosomes for degradation. In mucosal epithelium, mediates retrotranscytosis of antigen-IgM complexes across mucosal M cells toward antigen-presenting cells in mucosal lymphoid tissues . Triggers costimulatory signaling and mediates most of IgM effector functions involved in B cell development and primary immune response to infection. Likely limits tonic IgM BCR signaling to self-antigens for proper negative selection of autoreactive B cells in the bone marrow and for the maintenance of regulatory B cell pool in peripheral lymphoid organs. Mediates antibody responses to T cell-dependent and T cell-independent antigens and promotes induction of an efficient neutralizing IgG response. Engages in cross-talk with antigen-receptor signaling via the non-canonical NF-kappa-B, MAP kinases and calcium signaling pathways . .

AccessionsE9PQG1
ENST00000442471.4 [O60667-2]
ENST00000529560.1
ENST00000530505.1
ENST00000525793.5
E9PMT7
ENST00000367091.8 [O60667-1]
O60667
ENST00000628511.2 [O60667-3]
E9PPV1
ENST00000463473.2
E9PN59