CLDN4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0061436Biological processestablishment of skin barrier
GO_0022604Biological processregulation of cell morphogenesis
GO_0007155Biological processcell adhesion
GO_1905050Biological processpositive regulation of metallopeptidase activity
GO_0007565Biological processfemale pregnancy
GO_0007623Biological processcircadian rhythm
GO_0016338Biological processcalcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
GO_0070293Biological processrenal absorption
GO_1902476Biological processchloride transmembrane transport
GO_0030335Biological processpositive regulation of cell migration
GO_0070830Biological processbicellular tight junction assembly
GO_0032570Biological processresponse to progesterone
GO_0090303Biological processpositive regulation of wound healing
GO_0016324Cellular componentapical plasma membrane
GO_0070160Cellular componenttight junction
GO_0005886Cellular componentplasma membrane
GO_0009925Cellular componentbasal plasma membrane
GO_0005911Cellular componentcell-cell junction
GO_0034707Cellular componentchloride channel complex
GO_0016328Cellular componentlateral plasma membrane
GO_0005923Cellular componentbicellular tight junction
GO_0016327Cellular componentapicolateral plasma membrane
GO_0004888Molecular functiontransmembrane signaling receptor activity
GO_0042802Molecular functionidentical protein binding
GO_0005198Molecular functionstructural molecule activity
GO_0005515Molecular functionprotein binding
GO_0005254Molecular functionchloride channel activity

IV. Literature review

[source]
Gene nameCLDN4
Protein nameClaudin-4 (Clostridium perfringens enterotoxin receptor) (CPE-R) (CPE-receptor) (Williams-Beuren syndrome chromosomal region 8 protein)
Claudin
SynonymsCPER
CPETR1
WBSCR8
hCG_1737330
DescriptionFUNCTION: Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. .

FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. .

AccessionsQ75L80
ENST00000431918.1
ENST00000435050.1
ENST00000340958.4
O14493