SLC22A17 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015891Biological processsiderophore transport
GO_0006879Biological processintracellular iron ion homeostasis
GO_0055085Biological processtransmembrane transport
GO_0005774Cellular componentvacuolar membrane
GO_0031090Cellular componentorganelle membrane
GO_0005886Cellular componentplasma membrane
GO_0004888Molecular functiontransmembrane signaling receptor activity
GO_0005515Molecular functionprotein binding
GO_0022857Molecular functiontransmembrane transporter activity

IV. Literature review

[source]
Gene nameSLC22A17
Protein nameSolute carrier family 22 member 17 (24p3 receptor) (24p3R) (Brain-type organic cation transporter) (Lipocalin-2 receptor) (Neutrophil gelatinase-associated lipocalin receptor) (NgalR)
Solute carrier family 22 member 17
SynonymsBOCT
BOIT
DescriptionFUNCTION: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity). .

AccessionsENST00000397267.6 [Q8WUG5-1]
A0A1B0GUP4
ENST00000636431.2
H9KVA1
ENST00000474774.1
A0A1B0GUC0
ENST00000397260.7
A0A1B0GVR9
Q8WUG5
ENST00000354772.10 [Q8WUG5-2]
ENST00000474057.6