Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| astrocyte | 10 studies | 29% ± 14% | |
| oligodendrocyte precursor cell | 10 studies | 42% ± 19% | |
| GABAergic neuron | 9 studies | 41% ± 23% | |
| glutamatergic neuron | 9 studies | 43% ± 20% | |
| oligodendrocyte | 8 studies | 23% ± 5% | |
| neuron | 7 studies | 35% ± 13% | |
| amacrine cell | 5 studies | 31% ± 13% | |
| pancreatic A cell | 4 studies | 59% ± 25% | |
| retinal ganglion cell | 4 studies | 60% ± 21% | |
| retina horizontal cell | 4 studies | 39% ± 15% | |
| interneuron | 4 studies | 49% ± 14% | |
| pancreatic D cell | 3 studies | 43% ± 28% | |
| type B pancreatic cell | 3 studies | 43% ± 15% | |
| endothelial cell | 3 studies | 34% ± 10% | |
| fibroblast | 3 studies | 22% ± 5% | |
| Mueller cell | 3 studies | 19% ± 2% | |
| granule cell | 3 studies | 23% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 26067.63 | 2638 / 2642 | 100% | 296.81 | 703 / 705 |
| prostate | 99% | 8700.18 | 242 / 245 | 97% | 45.62 | 488 / 502 |
| thymus | 96% | 4943.52 | 628 / 653 | 91% | 58.55 | 548 / 605 |
| kidney | 72% | 2430.72 | 64 / 89 | 75% | 26.40 | 678 / 901 |
| ovary | 97% | 3939.53 | 175 / 180 | 47% | 14.10 | 204 / 430 |
| uterus | 95% | 4508.56 | 161 / 170 | 39% | 16.01 | 177 / 459 |
| breast | 54% | 2291.22 | 249 / 459 | 70% | 28.25 | 785 / 1118 |
| bladder | 81% | 2800.52 | 17 / 21 | 36% | 8.73 | 182 / 504 |
| adrenal gland | 26% | 1323.25 | 66 / 258 | 83% | 237.21 | 192 / 230 |
| pancreas | 9% | 241.70 | 29 / 328 | 75% | 44.62 | 133 / 178 |
| blood vessel | 83% | 3467.39 | 1108 / 1335 | 0% | 0 | 0 / 0 |
| skin | 25% | 674.30 | 458 / 1809 | 55% | 27.53 | 261 / 472 |
| intestine | 64% | 2936.95 | 622 / 966 | 9% | 2.55 | 45 / 527 |
| eye | 0% | 0 | 0 / 0 | 69% | 23.75 | 55 / 80 |
| esophagus | 51% | 1984.25 | 740 / 1445 | 15% | 2.95 | 27 / 183 |
| lung | 26% | 706.05 | 150 / 578 | 37% | 8.78 | 431 / 1155 |
| stomach | 37% | 1398.58 | 134 / 359 | 11% | 2.83 | 31 / 286 |
| heart | 38% | 1344.36 | 329 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 18% | 3.31 | 8 / 45 |
| adipose | 16% | 436.63 | 196 / 1204 | 0% | 0 | 0 / 0 |
| liver | 0% | 0 | 0 / 226 | 13% | 6.04 | 51 / 406 |
| spleen | 3% | 69.53 | 7 / 241 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0015891 | Biological process | siderophore transport |
| GO_0006879 | Biological process | intracellular iron ion homeostasis |
| GO_0055085 | Biological process | transmembrane transport |
| GO_0005774 | Cellular component | vacuolar membrane |
| GO_0031090 | Cellular component | organelle membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0004888 | Molecular function | transmembrane signaling receptor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0022857 | Molecular function | transmembrane transporter activity |
| Gene name | SLC22A17 |
| Protein name | Solute carrier family 22 member 17 (24p3 receptor) (24p3R) (Brain-type organic cation transporter) (Lipocalin-2 receptor) (Neutrophil gelatinase-associated lipocalin receptor) (NgalR) Solute carrier family 22 member 17 |
| Synonyms | BOCT BOIT |
| Description | FUNCTION: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity). . |
| Accessions | ENST00000397267.6 [Q8WUG5-1] A0A1B0GUP4 ENST00000636431.2 H9KVA1 ENST00000474774.1 A0A1B0GUC0 ENST00000397260.7 A0A1B0GVR9 Q8WUG5 ENST00000354772.10 [Q8WUG5-2] ENST00000474057.6 |