Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| macrophage | 10 studies | 27% ± 9% | |
| microglial cell | 8 studies | 33% ± 15% | |
| dendritic cell | 4 studies | 22% ± 9% | |
| non-classical monocyte | 3 studies | 22% ± 6% | |
| classical monocyte | 3 studies | 19% ± 4% | |
| myeloid cell | 3 studies | 21% ± 4% |
Insufficient scRNA-seq data for expression of TLR1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 99% | 358.87 | 453 / 459 | 93% | 8.78 | 1039 / 1118 |
| lung | 100% | 699.02 | 577 / 578 | 91% | 8.40 | 1050 / 1155 |
| pancreas | 94% | 280.53 | 308 / 328 | 89% | 5.91 | 158 / 178 |
| ovary | 98% | 421.53 | 177 / 180 | 75% | 4.35 | 322 / 430 |
| kidney | 78% | 161.88 | 69 / 89 | 85% | 8.12 | 766 / 901 |
| esophagus | 89% | 182.67 | 1285 / 1445 | 71% | 3.97 | 130 / 183 |
| uterus | 94% | 280.37 | 160 / 170 | 64% | 3.35 | 292 / 459 |
| skin | 70% | 115.66 | 1264 / 1809 | 80% | 7.25 | 379 / 472 |
| bladder | 100% | 245.43 | 21 / 21 | 49% | 2.97 | 247 / 504 |
| intestine | 98% | 280.10 | 943 / 966 | 48% | 2.53 | 252 / 527 |
| adrenal gland | 95% | 263.50 | 245 / 258 | 43% | 1.69 | 98 / 230 |
| stomach | 72% | 151.63 | 259 / 359 | 59% | 3.92 | 170 / 286 |
| prostate | 91% | 195.01 | 222 / 245 | 39% | 1.60 | 196 / 502 |
| brain | 44% | 84.24 | 1164 / 2642 | 78% | 6.52 | 551 / 705 |
| liver | 73% | 123.87 | 165 / 226 | 46% | 2.74 | 187 / 406 |
| thymus | 68% | 111.60 | 445 / 653 | 50% | 2.01 | 303 / 605 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 11.74 | 29 / 29 |
| peripheral blood | 100% | 4392.29 | 929 / 929 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1529.95 | 241 / 241 | 0% | 0 | 0 / 0 |
| adipose | 99% | 462.89 | 1197 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 89% | 276.56 | 1186 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 80% | 9.46 | 36 / 45 |
| heart | 64% | 108.97 | 548 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 45% | 2.17 | 36 / 80 |
| muscle | 11% | 11.12 | 86 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0002224 | Biological process | toll-like receptor signaling pathway |
| GO_0042116 | Biological process | macrophage activation |
| GO_0006954 | Biological process | inflammatory response |
| GO_0042495 | Biological process | detection of triacyl bacterial lipopeptide |
| GO_0071727 | Biological process | cellular response to triacyl bacterial lipopeptide |
| GO_0045087 | Biological process | innate immune response |
| GO_0007165 | Biological process | signal transduction |
| GO_0034137 | Biological process | positive regulation of toll-like receptor 2 signaling pathway |
| GO_0006955 | Biological process | immune response |
| GO_0032757 | Biological process | positive regulation of interleukin-8 production |
| GO_0032760 | Biological process | positive regulation of tumor necrosis factor production |
| GO_0032755 | Biological process | positive regulation of interleukin-6 production |
| GO_0043235 | Cellular component | receptor complex |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0045121 | Cellular component | membrane raft |
| GO_0016020 | Cellular component | membrane |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0030670 | Cellular component | phagocytic vesicle membrane |
| GO_0035354 | Cellular component | Toll-like receptor 1-Toll-like receptor 2 protein complex |
| GO_0038023 | Molecular function | signaling receptor activity |
| GO_0004888 | Molecular function | transmembrane signaling receptor activity |
| GO_0035663 | Molecular function | Toll-like receptor 2 binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0071723 | Molecular function | lipopeptide binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0061809 | Molecular function | NAD+ nucleotidase, cyclic ADP-ribose generating |
| Gene name | TLR1 |
| Protein name | Toll like receptor 1 Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281) Toll-like receptor 1 |
| Synonyms | KIAA0012 |
| Description | FUNCTION: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides . Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway . Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. . FUNCTION: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. . FUNCTION: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. . FUNCTION: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. . FUNCTION: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. . FUNCTION: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. . FUNCTION: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. . FUNCTION: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. . FUNCTION: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. . FUNCTION: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. . |
| Accessions | D1CS36 ENST00000505940.1 D1CS35 D1CS34 D1CS42 Q15399 ENST00000508364.1 D6RAP2 ENST00000308979.7 ENST00000506146.5 D1CS38 ENST00000502213.6 D1CS43 ENST00000515861.5 D6RA99 Q5FWG5 Q6FI64 D6RF68 D6RCE8 D1CS44 |
