Insufficient scRNA-seq data for expression of EDAR at single-cell level.
Insufficient scRNA-seq data for expression of EDAR at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
intestine | 49% | 63.98 | 469 / 966 | 85% | 13.17 | 446 / 527 |
esophagus | 39% | 244.32 | 563 / 1445 | 75% | 11.95 | 138 / 183 |
bladder | 57% | 342.57 | 12 / 21 | 49% | 4.98 | 248 / 504 |
kidney | 70% | 52.15 | 62 / 89 | 35% | 2.06 | 314 / 901 |
ureter | 0% | 0 | 0 / 0 | 100% | 4.06 | 1 / 1 |
stomach | 19% | 9.79 | 67 / 359 | 77% | 11.55 | 221 / 286 |
pancreas | 15% | 7.59 | 50 / 328 | 79% | 5.88 | 140 / 178 |
prostate | 62% | 66.19 | 152 / 245 | 25% | 0.65 | 123 / 502 |
liver | 54% | 34.55 | 121 / 226 | 23% | 1.01 | 93 / 406 |
skin | 71% | 204.43 | 1287 / 1809 | 4% | 0.20 | 19 / 472 |
lung | 20% | 8.26 | 115 / 578 | 44% | 2.54 | 506 / 1155 |
uterus | 9% | 14.65 | 16 / 170 | 50% | 3.34 | 228 / 459 |
ovary | 1% | 0.31 | 2 / 180 | 39% | 1.72 | 166 / 430 |
peripheral blood | 35% | 23.19 | 327 / 929 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 33% | 1.66 | 15 / 45 |
spleen | 32% | 12.71 | 76 / 241 | 0% | 0 | 0 / 0 |
breast | 16% | 14.22 | 73 / 459 | 7% | 0.29 | 73 / 1118 |
thymus | 4% | 3.01 | 24 / 653 | 13% | 1.28 | 79 / 605 |
lymph node | 0% | 0 | 0 / 0 | 10% | 0.40 | 3 / 29 |
brain | 3% | 1.25 | 72 / 2642 | 5% | 0.09 | 34 / 705 |
adipose | 3% | 4.13 | 40 / 1204 | 0% | 0 | 0 / 0 |
adrenal gland | 1% | 0.42 | 2 / 258 | 2% | 0.03 | 4 / 230 |
heart | 1% | 0.37 | 7 / 861 | 0% | 0 | 0 / 0 |
muscle | 0% | 0.31 | 4 / 803 | 0% | 0 | 0 / 0 |
blood vessel | 0% | 0.40 | 6 / 1335 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0042475 | Biological process | odontogenesis of dentin-containing tooth |
GO_0006915 | Biological process | apoptotic process |
GO_0010628 | Biological process | positive regulation of gene expression |
GO_0019221 | Biological process | cytokine-mediated signaling pathway |
GO_1901224 | Biological process | positive regulation of non-canonical NF-kappaB signal transduction |
GO_0008544 | Biological process | epidermis development |
GO_0043123 | Biological process | positive regulation of canonical NF-kappaB signal transduction |
GO_0030154 | Biological process | cell differentiation |
GO_0043473 | Biological process | pigmentation |
GO_0060662 | Biological process | salivary gland cavitation |
GO_0001942 | Biological process | hair follicle development |
GO_0046330 | Biological process | positive regulation of JNK cascade |
GO_0045177 | Cellular component | apical part of cell |
GO_0005886 | Cellular component | plasma membrane |
GO_0016020 | Cellular component | membrane |
GO_0004888 | Molecular function | transmembrane signaling receptor activity |
GO_0038023 | Molecular function | signaling receptor activity |
GO_0005515 | Molecular function | protein binding |
Gene name | EDAR |
Protein name | Tumor necrosis factor receptor superfamily member EDAR (Anhidrotic ectodysplasin receptor 1) (Downless homolog) (EDA-A1 receptor) (Ectodermal dysplasia receptor) (Ectodysplasin-A receptor) |
Synonyms | DL |
Description | FUNCTION: Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death. |
Accessions | ENST00000409271.5 [Q9UNE0-2] Q9UNE0 ENST00000376651.1 [Q9UNE0-2] ENST00000258443.7 [Q9UNE0-1] |