CD247 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	47 studies	71% ± 18%	Explore
CD8-positive, alpha-beta T cell	37 studies	40% ± 16%	Explore
CD4-positive, alpha-beta T cell	34 studies	40% ± 14%	Explore
T cell	33 studies	39% ± 13%	Explore
regulatory T cell	29 studies	50% ± 14%	Explore
mature NK T cell	22 studies	59% ± 19%	Explore
gamma-delta T cell	18 studies	54% ± 17%	Explore
mucosal invariant T cell	17 studies	41% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	39% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	65% ± 17%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	79% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	43% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	40% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	41% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	42% ± 13%	Explore
innate lymphoid cell	7 studies	39% ± 23%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	41% ± 16%	Explore
T follicular helper cell	7 studies	39% ± 6%	Explore
CD4-positive helper T cell	6 studies	25% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	41% ± 10%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	43% ± 19%	Explore
exhausted T cell	5 studies	56% ± 12%	Explore
leukocyte	5 studies	36% ± 22%	Explore
lymphocyte	5 studies	54% ± 19%	Explore
T-helper 17 cell	5 studies	43% ± 17%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	39% ± 20%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	22% ± 4%	Explore
group 3 innate lymphoid cell	4 studies	54% ± 25%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	51% ± 13%	Explore
double negative thymocyte	4 studies	44% ± 13%	Explore
intraepithelial lymphocyte	3 studies	59% ± 21%	Explore
GABAergic neuron	3 studies	22% ± 5%	Explore
glutamatergic neuron	3 studies	23% ± 2%	Explore
T-helper 1 cell	3 studies	53% ± 10%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	32% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	17 studies	30% ± 8%	Explore
lung	4 studies	18% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	1193.30	578 / 578	83%	5.91	954 / 1155
stomach	91%	195.27	327 / 359	64%	3.06	184 / 286
uterus	80%	129.74	136 / 170	74%	6.06	339 / 459
breast	86%	216.09	397 / 459	64%	4.99	714 / 1118
bladder	90%	260.90	19 / 21	60%	4.15	301 / 504
thymus	93%	306.95	609 / 653	55%	24.42	334 / 605
kidney	70%	186.70	62 / 89	73%	6.57	662 / 901
intestine	73%	489.03	701 / 966	65%	3.37	342 / 527
prostate	90%	203.24	221 / 245	44%	1.86	220 / 502
liver	92%	287.77	209 / 226	40%	2.19	163 / 406
esophagus	64%	101.80	919 / 1445	38%	1.68	70 / 183
skin	42%	55.87	764 / 1809	60%	6.97	281 / 472
lymph node	0%	0	0 / 0	100%	44.16	29 / 29
spleen	100%	3668.56	241 / 241	0%	0	0 / 0
adipose	94%	293.78	1133 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	91%	12.46	41 / 45
brain	78%	124.23	2065 / 2642	11%	0.38	75 / 705
peripheral blood	84%	5477.53	782 / 929	0%	0	0 / 0
pancreas	7%	9.22	24 / 328	70%	5.43	125 / 178
ovary	33%	43.55	59 / 180	27%	1.05	118 / 430
blood vessel	58%	118.04	778 / 1335	0%	0	0 / 0
adrenal gland	33%	37.55	86 / 258	13%	0.47	30 / 230
heart	44%	64.42	378 / 861	0%	0	0 / 0
muscle	16%	18.87	130 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	15%	0.96	12 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0046629	Biological process	gamma-delta T cell activation
GO_0046631	Biological process	alpha-beta T cell activation
GO_0050852	Biological process	T cell receptor signaling pathway
GO_2000010	Biological process	positive regulation of protein localization to cell surface
GO_0065003	Biological process	protein-containing complex assembly
GO_0002250	Biological process	adaptive immune response
GO_0051259	Biological process	protein complex oligomerization
GO_0038094	Biological process	Fc-gamma receptor signaling pathway
GO_0007166	Biological process	cell surface receptor signaling pathway
GO_0005886	Cellular component	plasma membrane
GO_0033001	Cellular component	Fc-gamma receptor III complex
GO_0005794	Cellular component	Golgi apparatus
GO_0042105	Cellular component	alpha-beta T cell receptor complex
GO_0005737	Cellular component	cytoplasm
GO_0042101	Cellular component	T cell receptor complex
GO_0042106	Cellular component	gamma-delta T cell receptor complex
GO_0042803	Molecular function	protein homodimerization activity
GO_0004888	Molecular function	transmembrane signaling receptor activity
GO_0042802	Molecular function	identical protein binding
GO_1990782	Molecular function	protein tyrosine kinase binding
GO_0046982	Molecular function	protein heterodimerization activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CD247
Protein name	CD247 T-cell surface glycoprotein CD3 zeta chain (T-cell receptor T3 zeta chain) (CD antigen CD247) T-cell surface glycoprotein CD3 zeta chain (T-cell receptor T3 zeta chain) Alternative protein CD247 (CD247 antigen, isoform CRA_a) CD247 molecule CD247 transcript variant 2
Synonyms	TCRZ T3Z CD3Z hCG_1769040
Description	FUNCTION: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways . CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme . Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN) (By similarity). .
Accessions	A0A8V8TPR5 A0A8V8TPQ0 ENST00000700109.1 ENST00000700107.1 H6QVQ5 ENST00000470379.2 ENST00000700165.1 ENST00000700159.1 A0A8V8TR07 ENST00000700108.1 A0A8V8TQY8 ENST00000700157.1 ENST00000700155.1 ENST00000485089.6 ENST00000700160.1 A0A8V8TPD9 A0A8V8TPS3 A0A8V8TPT5 ENST00000700167.1 ENST00000476733.6 A0A8V8TPB2 A0A8V8TPX3 ENST00000700156.1 ENST00000700158.1 B2LYR2 A0A8V8TPD5 A0A8V8TPP4 ENST00000700163.1 ENST00000700134.1 P20963 A0A8V8TQM0 ENST00000392122.4 [P20963-3] ENST00000700142.1 ENST00000700105.1 ENST00000362089.10 [P20963-1] A0A8V8TQN4 ENST00000700113.1 A0A8V8TQP3 A9Y844 L8ECP7 ENST00000700106.1 ENST00000700161.1

CD247 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review