LYVE1 | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell of lymphatic vessel	27 studies	51% ± 18%	Explore
macrophage	25 studies	42% ± 20%	Explore
endothelial cell	8 studies	32% ± 14%	Explore
capillary endothelial cell	4 studies	26% ± 12%	Explore
endothelial cell of sinusoid	4 studies	39% ± 28%	Explore
myeloid cell	4 studies	36% ± 8%	Explore
dendritic cell	3 studies	19% ± 0%	Explore
mononuclear phagocyte	3 studies	28% ± 5%	Explore
astrocyte	3 studies	34% ± 6%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of LYVE1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	8913.10	258 / 258	87%	44.93	200 / 230
lung	98%	5304.84	566 / 578	74%	5.78	850 / 1155
breast	97%	6525.64	446 / 459	42%	3.04	467 / 1118
thymus	91%	4037.74	591 / 653	47%	2.81	283 / 605
kidney	63%	1782.20	56 / 89	74%	12.88	666 / 901
intestine	96%	5153.87	925 / 966	37%	3.08	193 / 527
bladder	95%	3661.57	20 / 21	37%	4.99	187 / 504
esophagus	80%	3739.99	1161 / 1445	45%	3.37	83 / 183
ovary	67%	1931.38	120 / 180	58%	4.87	249 / 430
spleen	100%	13100.37	241 / 241	0%	0	0 / 0
stomach	52%	2367.70	188 / 359	48%	2.76	136 / 286
adipose	99%	13518.00	1196 / 1204	0%	0	0 / 0
uterus	68%	1739.31	115 / 170	25%	2.38	115 / 459
blood vessel	89%	3908.96	1191 / 1335	0%	0	0 / 0
skin	47%	1148.58	842 / 1809	41%	4.22	195 / 472
liver	45%	1161.91	101 / 226	43%	3.66	173 / 406
brain	6%	87.70	169 / 2642	79%	13.67	559 / 705
prostate	44%	929.62	107 / 245	35%	1.50	175 / 502
pancreas	12%	157.94	40 / 328	65%	6.40	116 / 178
heart	62%	1828.61	536 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	55%	2.83	16 / 29
tonsil	0%	0	0 / 0	33%	1.36	15 / 45
muscle	29%	486.66	232 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	21%	1.34	17 / 80
peripheral blood	8%	271.69	76 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0009611	Biological process	response to wounding
GO_0030214	Biological process	hyaluronan catabolic process
GO_0006898	Biological process	receptor-mediated endocytosis
GO_0002693	Biological process	positive regulation of cellular extravasation
GO_0007160	Biological process	cell-matrix adhesion
GO_0009653	Biological process	anatomical structure morphogenesis
GO_0070062	Cellular component	extracellular exosome
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0004888	Molecular function	transmembrane signaling receptor activity
GO_0038023	Molecular function	signaling receptor activity
GO_0038024	Molecular function	cargo receptor activity
GO_0005515	Molecular function	protein binding
GO_0005540	Molecular function	hyaluronic acid binding

Gene name	LYVE1
Protein name	Lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE-1) (Cell surface retention sequence-binding protein 1) (CRSBP-1) (Extracellular link domain-containing protein 1) (Hyaluronic acid receptor) Lymphatic vessel endothelial hyaluronan receptor 1
Synonyms	HAR UNQ230/PRO263 XLKD1 CRSBP1
Description	FUNCTION: Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes . Binds to pericelluar hyaluronan matrices deposited on the surface of leukocytes and facilitates cell adhesion and migration through lymphatic endothelium . .
Accessions	E7EPC7 Q9Y5Y7 ENST00000438354.6 ENST00000529598.1 F2Z296 ENST00000256178.8

LYVE1 report