KLRB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042269Biological processregulation of natural killer cell mediated cytotoxicity
GO_0007166Biological processcell surface receptor signaling pathway
GO_0009986Cellular componentcell surface
GO_0005886Cellular componentplasma membrane
GO_0004888Molecular functiontransmembrane signaling receptor activity
GO_0038023Molecular functionsignaling receptor activity
GO_0030246Molecular functioncarbohydrate binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKLRB1
Protein nameKiller cell lectin-like receptor subfamily B member 1 (C-type lectin domain family 5 member B) (HNKR-P1a) (NKR-P1A) (Natural killer cell surface protein P1A) (CD antigen CD161)
SynonymsCLEC5B
NKRP1A
DescriptionFUNCTION: Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. .

AccessionsQ12918
ENST00000229402.4