Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 100% | 452.87 | 578 / 578 | 81% | 6.43 | 932 / 1155 |
kidney | 75% | 98.26 | 67 / 89 | 83% | 7.53 | 745 / 901 |
stomach | 85% | 96.51 | 305 / 359 | 71% | 4.62 | 203 / 286 |
liver | 92% | 120.74 | 208 / 226 | 62% | 4.42 | 253 / 406 |
prostate | 82% | 94.85 | 202 / 245 | 67% | 3.99 | 336 / 502 |
thymus | 86% | 87.51 | 561 / 653 | 61% | 5.38 | 372 / 605 |
intestine | 74% | 283.66 | 719 / 966 | 71% | 4.29 | 373 / 527 |
breast | 81% | 78.53 | 370 / 459 | 61% | 4.08 | 686 / 1118 |
uterus | 60% | 35.83 | 102 / 170 | 62% | 4.07 | 284 / 459 |
bladder | 67% | 101.29 | 14 / 21 | 50% | 2.89 | 250 / 504 |
spleen | 100% | 1458.63 | 241 / 241 | 0% | 0 | 0 / 0 |
pancreas | 16% | 9.72 | 51 / 328 | 78% | 7.58 | 139 / 178 |
adipose | 91% | 144.65 | 1091 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 83% | 12.51 | 24 / 29 |
tonsil | 0% | 0 | 0 / 0 | 82% | 8.11 | 37 / 45 |
esophagus | 35% | 26.06 | 500 / 1445 | 46% | 2.65 | 85 / 183 |
peripheral blood | 81% | 1099.63 | 752 / 929 | 0% | 0 | 0 / 0 |
skin | 11% | 5.32 | 193 / 1809 | 43% | 2.51 | 204 / 472 |
ovary | 25% | 16.79 | 45 / 180 | 25% | 0.94 | 107 / 430 |
blood vessel | 50% | 54.70 | 661 / 1335 | 0% | 0 | 0 / 0 |
adrenal gland | 17% | 10.29 | 44 / 258 | 23% | 1.00 | 54 / 230 |
heart | 26% | 15.46 | 223 / 861 | 0% | 0 | 0 / 0 |
brain | 10% | 5.72 | 263 / 2642 | 10% | 0.37 | 71 / 705 |
eye | 0% | 0 | 0 / 0 | 10% | 0.37 | 8 / 80 |
muscle | 1% | 0.72 | 9 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0042269 | Biological process | regulation of natural killer cell mediated cytotoxicity |
GO_0007166 | Biological process | cell surface receptor signaling pathway |
GO_0009986 | Cellular component | cell surface |
GO_0005886 | Cellular component | plasma membrane |
GO_0004888 | Molecular function | transmembrane signaling receptor activity |
GO_0038023 | Molecular function | signaling receptor activity |
GO_0030246 | Molecular function | carbohydrate binding |
GO_0005515 | Molecular function | protein binding |
Gene name | KLRB1 |
Protein name | Killer cell lectin-like receptor subfamily B member 1 (C-type lectin domain family 5 member B) (HNKR-P1a) (NKR-P1A) (Natural killer cell surface protein P1A) (CD antigen CD161) |
Synonyms | CLEC5B NKRP1A |
Description | FUNCTION: Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. . |
Accessions | Q12918 ENST00000229402.4 |