CD300A | OmnibusX

Name	Number of supported studies	Average coverage
natural killer cell	32 studies	27% ± 9%	Explore
non-classical monocyte	22 studies	38% ± 13%	Explore
macrophage	20 studies	30% ± 13%	Explore
conventional dendritic cell	17 studies	25% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	36% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	33% ± 12%	Explore
monocyte	14 studies	24% ± 7%	Explore
plasmacytoid dendritic cell	10 studies	27% ± 8%	Explore
classical monocyte	9 studies	31% ± 11%	Explore
myeloid cell	8 studies	26% ± 9%	Explore
gamma-delta T cell	8 studies	21% ± 3%	Explore
mature NK T cell	7 studies	26% ± 8%	Explore
dendritic cell	7 studies	30% ± 14%	Explore
microglial cell	5 studies	29% ± 8%	Explore
leukocyte	4 studies	20% ± 3%	Explore
neutrophil	3 studies	22% ± 8%	Explore
mononuclear phagocyte	3 studies	39% ± 12%	Explore
CD8-positive, alpha-beta T cell	3 studies	23% ± 5%	Explore
hematopoietic precursor cell	3 studies	24% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	6 studies	19% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	1345.45	577 / 578	95%	17.44	1093 / 1155
breast	86%	320.48	396 / 459	97%	13.43	1087 / 1118
intestine	83%	417.23	797 / 966	82%	9.74	430 / 527
bladder	86%	406.90	18 / 21	77%	10.27	390 / 504
brain	64%	232.98	1696 / 2642	96%	21.02	680 / 705
liver	93%	324.69	211 / 226	62%	5.46	252 / 406
prostate	90%	296.59	220 / 245	63%	3.63	314 / 502
adrenal gland	95%	448.45	246 / 258	57%	9.24	131 / 230
uterus	62%	131.66	105 / 170	89%	9.84	410 / 459
kidney	57%	195.78	51 / 89	90%	21.64	815 / 901
stomach	65%	159.03	233 / 359	81%	8.16	232 / 286
skin	60%	137.11	1080 / 1809	84%	12.55	396 / 472
thymus	61%	153.98	401 / 653	74%	8.54	445 / 605
pancreas	27%	65.39	87 / 328	93%	17.97	166 / 178
esophagus	52%	119.91	757 / 1445	64%	4.44	118 / 183
ovary	33%	66.73	59 / 180	80%	7.81	346 / 430
lymph node	0%	0	0 / 0	100%	32.59	29 / 29
peripheral blood	100%	13547.39	929 / 929	0%	0	0 / 0
spleen	100%	6756.79	241 / 241	0%	0	0 / 0
adipose	95%	561.37	1145 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	14.12	42 / 45
blood vessel	68%	276.16	911 / 1335	0%	0	0 / 0
heart	50%	143.65	434 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	33%	2.41	26 / 80
muscle	4%	5.69	29 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0060101	Biological process	negative regulation of phagocytosis, engulfment
GO_0043305	Biological process	negative regulation of mast cell degranulation
GO_0002376	Biological process	immune system process
GO_0034125	Biological process	negative regulation of MyD88-dependent toll-like receptor signaling pathway
GO_0048147	Biological process	negative regulation of fibroblast proliferation
GO_0050859	Biological process	negative regulation of B cell receptor signaling pathway
GO_0033007	Biological process	negative regulation of mast cell activation involved in immune response
GO_1902564	Biological process	negative regulation of neutrophil activation
GO_0007155	Biological process	cell adhesion
GO_2000417	Biological process	negative regulation of eosinophil migration
GO_0051134	Biological process	negative regulation of NK T cell activation
GO_1902569	Biological process	negative regulation of activation of Janus kinase activity
GO_0043407	Biological process	negative regulation of MAP kinase activity
GO_0050856	Biological process	regulation of T cell receptor signaling pathway
GO_0032516	Biological process	positive regulation of phosphoprotein phosphatase activity
GO_1902567	Biological process	negative regulation of eosinophil activation
GO_0030889	Biological process	negative regulation of B cell proliferation
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0070062	Cellular component	extracellular exosome
GO_0070821	Cellular component	tertiary granule membrane
GO_0101003	Cellular component	ficolin-1-rich granule membrane
GO_0038023	Molecular function	signaling receptor activity
GO_0004888	Molecular function	transmembrane signaling receptor activity
GO_0001786	Molecular function	phosphatidylserine binding
GO_0008429	Molecular function	phosphatidylethanolamine binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CD300A
Protein name	CMRF35-like molecule 8 (CLM-8) (CD300 antigen-like family member A) (CMRF-35-H9) (CMRF35-H9) (CMRF35-H) (IRC1/IRC2) (Immunoglobulin superfamily member 12) (IgSF12) (Inhibitory receptor protein 60) (IRp60) (NK inhibitory receptor) (CD antigen CD300a) CD300a molecule
Synonyms	HSPC083 CMRF35H IGSF12
Description	FUNCTION: Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation . Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 . .
Accessions	ENST00000577511.1 ENST00000361933.7 [Q9UGN4-3] J3QKQ4 Q9UGN4 ENST00000709202.1 [Q9UGN4-1] ENST00000648095.1 ENST00000709203.1 [Q9UGN4-4] ENST00000392625.7 [Q9UGN4-4] ENST00000709205.1 [Q9UGN4-3] ENST00000310828.9 [Q9UGN4-2] ENST00000709204.1 [Q9UGN4-2] ENST00000360141.8 [Q9UGN4-1]

CD300A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review