SIGLEC8 | OmnibusX

Name	Number of supported studies	Average coverage
microglial cell	5 studies	23% ± 7%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of SIGLEC8 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	89%	272.74	2353 / 2642	98%	28.47	691 / 705
breast	66%	62.93	303 / 459	68%	3.99	757 / 1118
adrenal gland	98%	330.97	253 / 258	33%	1.48	75 / 230
lung	91%	142.98	528 / 578	39%	1.88	453 / 1155
prostate	89%	92.42	217 / 245	25%	0.88	123 / 502
stomach	77%	58.49	276 / 359	25%	1.41	72 / 286
bladder	90%	149.48	19 / 21	11%	0.49	57 / 504
spleen	95%	877.37	229 / 241	0%	0	0 / 0
kidney	17%	13.04	15 / 89	74%	8.31	663 / 901
lymph node	0%	0	0 / 0	86%	9.44	25 / 29
esophagus	75%	84.58	1090 / 1445	9%	0.46	17 / 183
intestine	70%	146.85	679 / 966	14%	0.65	76 / 527
skin	37%	24.04	673 / 1809	38%	2.74	177 / 472
pancreas	29%	15.21	96 / 328	43%	2.45	76 / 178
uterus	56%	50.62	95 / 170	13%	0.64	59 / 459
adipose	56%	40.02	676 / 1204	0%	0	0 / 0
thymus	18%	16.64	118 / 653	25%	1.35	151 / 605
liver	25%	17.13	56 / 226	10%	0.41	42 / 406
ovary	13%	7.70	24 / 180	22%	0.99	93 / 430
tonsil	0%	0	0 / 0	33%	1.75	15 / 45
eye	0%	0	0 / 0	31%	1.99	25 / 80
blood vessel	29%	31.72	387 / 1335	0%	0	0 / 0
peripheral blood	28%	40.42	262 / 929	0%	0	0 / 0
heart	3%	1.11	27 / 861	0%	0	0 / 0
muscle	2%	0.59	15 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0007165	Biological process	signal transduction
GO_0007155	Biological process	cell adhesion
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0004888	Molecular function	transmembrane signaling receptor activity
GO_0030246	Molecular function	carbohydrate binding
GO_0005515	Molecular function	protein binding
GO_0033691	Molecular function	sialic acid binding

Gene name	SIGLEC8
Protein name	Sialic acid-binding Ig-like lectin 8 (Siglec-8) (Sialoadhesin family member 2) (SAF-2) Sialic acid binding Ig like lectin 8
Synonyms	SAF2
Description	FUNCTION: Putative adhesion molecule that mediates sialic-acid dependent binding to red blood cells . Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface . Recognizes simultaneously epitopes having a terminal N-acetylneuraminic acid (sialic acid) and an underlying 6-O-sulfated galactose. Preferentially binds to Gal-6-sulfated sialyl-Lewis X glycan epitopes . .
Accessions	ENST00000340550.5 [Q9NYZ4-2] ENST00000321424.7 [Q9NYZ4-1] C9JT30 ENST00000430817.5 Q9NYZ4

SIGLEC8 report