NFAM1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NFAM1 at tissue level.

III. Associated gene sets

GO_0045577Biological processregulation of B cell differentiation
GO_0007165Biological processsignal transduction
GO_0050853Biological processB cell receptor signaling pathway
GO_0033173Biological processcalcineurin-NFAT signaling cascade
GO_0050861Biological processpositive regulation of B cell receptor signaling pathway
GO_0001819Biological processpositive regulation of cytokine production
GO_0035556Biological processintracellular signal transduction
GO_0006954Biological processinflammatory response
GO_0030183Biological processB cell differentiation
GO_0045121Cellular componentmembrane raft
GO_0035577Cellular componentazurophil granule membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0004888Molecular functiontransmembrane signaling receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNFAM1
Protein nameNFAT activation molecule 1 (Calcineurin/NFAT-activating ITAM-containing protein) (NFAT-activating protein with ITAM motif 1)
SynonymsCNAIP
DescriptionFUNCTION: May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking. .

AccessionsENST00000329021.10
Q8NET5