NGFR report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NGFR at tissue level.

III. Associated gene sets

GO_0042475Biological processodontogenesis of dentin-containing tooth
GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_1903588Biological processnegative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO_0048146Biological processpositive regulation of fibroblast proliferation
GO_0021675Biological processnerve development
GO_0031069Biological processhair follicle morphogenesis
GO_0006886Biological processintracellular protein transport
GO_0035907Biological processdorsal aorta development
GO_0001678Biological processintracellular glucose homeostasis
GO_0032922Biological processcircadian regulation of gene expression
GO_0051799Biological processnegative regulation of hair follicle development
GO_0042488Biological processpositive regulation of odontogenesis of dentin-containing tooth
GO_0051402Biological processneuron apoptotic process
GO_0016048Biological processdetection of temperature stimulus
GO_1902895Biological processpositive regulation of miRNA transcription
GO_0048144Biological processfibroblast proliferation
GO_0099171Biological processpresynaptic modulation of chemical synaptic transmission
GO_0007417Biological processcentral nervous system development
GO_0007266Biological processRho protein signal transduction
GO_0030336Biological processnegative regulation of cell migration
GO_2001235Biological processpositive regulation of apoptotic signaling pathway
GO_0040037Biological processnegative regulation of fibroblast growth factor receptor signaling pathway
GO_0042593Biological processglucose homeostasis
GO_0007411Biological processaxon guidance
GO_1900182Biological processpositive regulation of protein localization to nucleus
GO_0008543Biological processfibroblast growth factor receptor signaling pathway
GO_0098793Cellular componentpresynapse
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0031594Cellular componentneuromuscular junction
GO_0043197Cellular componentdendritic spine
GO_0016020Cellular componentmembrane
GO_0043204Cellular componentperikaryon
GO_0005654Cellular componentnucleoplasm
GO_0005911Cellular componentcell-cell junction
GO_0009986Cellular componentcell surface
GO_0005829Cellular componentcytosol
GO_0014069Cellular componentpostsynaptic density
GO_0030426Cellular componentgrowth cone
GO_0005768Cellular componentendosome
GO_0015026Molecular functioncoreceptor activity
GO_0038023Molecular functionsignaling receptor activity
GO_0005035Molecular functiondeath receptor activity
GO_0004888Molecular functiontransmembrane signaling receptor activity
GO_0001540Molecular functionamyloid-beta binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0031267Molecular functionsmall GTPase binding
GO_0043121Molecular functionneurotrophin binding
GO_0048406Molecular functionnerve growth factor binding
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNGFR
Protein nameTumor necrosis factor receptor superfamily member 16 (Gp80-LNGFR) (Low affinity neurotrophin receptor p75NTR) (Low-affinity nerve growth factor receptor) (NGF receptor) (Low-affinity nerve growth factor receptor p75NGFR) (Low-affinity nerve growth factor receptor p75NGR) (p75 ICD) (CD antigen CD271)
SynonymsTNFRSF16
DescriptionFUNCTION: Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF . Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA . Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver . .

AccessionsENST00000504201.1 [P08138-2]
P08138
ENST00000172229.8 [P08138-1]