PIGR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0038093Biological processFc receptor signaling pathway
GO_0007173Biological processepidermal growth factor receptor signaling pathway
GO_0001580Biological processdetection of chemical stimulus involved in sensory perception of bitter taste
GO_0002415Biological processimmunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor
GO_0043113Biological processreceptor clustering
GO_0005615Cellular componentextracellular space
GO_0035577Cellular componentazurophil granule membrane
GO_0070062Cellular componentextracellular exosome
GO_0043235Cellular componentreceptor complex
GO_0005886Cellular componentplasma membrane
GO_0071751Cellular componentsecretory IgA immunoglobulin complex
GO_0004888Molecular functiontransmembrane signaling receptor activity
GO_0001790Molecular functionpolymeric immunoglobulin binding
GO_0001792Molecular functionpolymeric immunoglobulin receptor activity

IV. Literature review

[source]
Gene namePIGR
Protein namePolymeric immunoglobulin receptor (PIgR) (Poly-Ig receptor) (Hepatocellular carcinoma-associated protein TB6) [Cleaved into: Secretory component]
Polymeric immunoglobulin receptor
Synonyms
DescriptionFUNCTION: [Polymeric immunoglobulin receptor]: Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. .; FUNCTION: [Secretory component]: Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens . On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells . .

AccessionsP01833
ENST00000356495.5
Q8TE27