secretory IgA immunoglobulin complex

I. Literature review

[source]
Namesecretory IgA immunoglobulin complex
IDGO_0071751
collection_id

Cellular component

Exact synonym

sIgA antibody, secretory IgA antibody

Description

A polymeric IgA immunoglobulin complex that is complexed with one chain of secretory component (SC). Polymeric IgA is present in mucosal areas, having been transported via a transcytosis mechanism in mucosal epithelial cells relying on the polymeric Ig receptor, a portion of which then remains bound to the polymeric IgA as secretory component.

Comment

Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. In human only the IgA1 isotype in the polymeric form is capable of becoming secretory IgA.

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