JCHAIN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0003094Biological processglomerular filtration
GO_0045087Biological processinnate immune response
GO_0019731Biological processantibacterial humoral response
GO_0065003Biological processprotein-containing complex assembly
GO_0006959Biological processhumoral immune response
GO_0006955Biological processimmune response
GO_0002250Biological processadaptive immune response
GO_0060267Biological processpositive regulation of respiratory burst
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0070062Cellular componentextracellular exosome
GO_0071756Cellular componentpentameric IgM immunoglobulin complex
GO_0071752Cellular componentsecretory dimeric IgA immunoglobulin complex
GO_0071751Cellular componentsecretory IgA immunoglobulin complex
GO_0072562Cellular componentblood microparticle
GO_0071750Cellular componentdimeric IgA immunoglobulin complex
GO_0071748Cellular componentmonomeric IgA immunoglobulin complex
GO_0071757Cellular componenthexameric IgM immunoglobulin complex
GO_0042803Molecular functionprotein homodimerization activity
GO_0042834Molecular functionpeptidoglycan binding
GO_0019862Molecular functionIgA binding
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0034987Molecular functionimmunoglobulin receptor binding
GO_0031210Molecular functionphosphatidylcholine binding
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0003823Molecular functionantigen binding

IV. Literature review

[source]
Gene nameJCHAIN
Protein nameJoining chain of multimeric IgA and IgM
Immunoglobulin J chain (Joining chain of multimeric IgA and IgM)
SynonymsIGCJ
IGJ
DescriptionFUNCTION: Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces dimers and/or larger polymers. It also helps to bind these immunoglobulins to secretory component. .

AccessionsENST00000254801.9
ENST00000510614.5
ENST00000470866.1
ENST00000510437.5
P01591
ENST00000391614.7
D6RHJ6
D6RD17
C9JA05