IGKV3-20 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IGKV3-20 at tissue level.

III. Associated gene sets

GO_0006955Biological processimmune response
GO_0002250Biological processadaptive immune response
GO_0002377Biological processimmunoglobulin production
GO_0003094Biological processglomerular filtration
GO_0019731Biological processantibacterial humoral response
GO_0005615Cellular componentextracellular space
GO_0072562Cellular componentblood microparticle
GO_0070062Cellular componentextracellular exosome
GO_0071756Cellular componentpentameric IgM immunoglobulin complex
GO_0005576Cellular componentextracellular region
GO_0071751Cellular componentsecretory IgA immunoglobulin complex
GO_0005886Cellular componentplasma membrane
GO_0071748Cellular componentmonomeric IgA immunoglobulin complex
GO_0003823Molecular functionantigen binding

IV. Literature review

[source]
Gene nameIGKV3-20
Protein nameImmunoglobulin kappa variable 3-20 (Ig kappa chain V-III region B6) (Ig kappa chain V-III region GOL) (Ig kappa chain V-III region HAH) (Ig kappa chain V-III region HIC) (Ig kappa chain V-III region IARC/BL41) (Ig kappa chain V-III region NG9) (Ig kappa chain V-III region SIE) (Ig kappa chain V-III region Ti) (Ig kappa chain V-III region WOL)
Synonyms
DescriptionFUNCTION: V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen . .

AccessionsP01619
ENST00000492167.1
ENST00000632822.1