GP6 | OmnibusX

Name	Number of supported studies	Average coverage
platelet	4 studies	25% ± 11%	Explore
megakaryocyte	3 studies	39% ± 7%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of GP6 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	88%	33.74	158 / 180	33%	0.79	143 / 430
prostate	93%	49.70	228 / 245	12%	0.18	59 / 502
lung	95%	107.65	550 / 578	8%	0.18	91 / 1155
spleen	100%	99.81	241 / 241	0%	0	0 / 0
kidney	74%	26.11	66 / 89	25%	0.54	227 / 901
thymus	95%	51.87	623 / 653	3%	0.04	18 / 605
esophagus	73%	57.62	1048 / 1445	25%	0.47	45 / 183
brain	93%	101.49	2444 / 2642	3%	0.04	18 / 705
heart	91%	47.91	782 / 861	0%	0	0 / 0
uterus	81%	31.05	138 / 170	8%	0.29	36 / 459
peripheral blood	83%	105.82	767 / 929	0%	0	0 / 0
intestine	73%	23.44	706 / 966	7%	0.13	35 / 527
breast	61%	25.60	278 / 459	13%	0.25	141 / 1118
skin	72%	75.24	1300 / 1809	1%	0.03	6 / 472
bladder	62%	17.86	13 / 21	11%	0.82	55 / 504
pancreas	47%	12.30	153 / 328	17%	0.32	31 / 178
stomach	55%	14.28	196 / 359	9%	0.18	25 / 286
liver	38%	9.33	85 / 226	1%	0.02	6 / 406
adipose	37%	9.28	448 / 1204	0%	0	0 / 0
muscle	27%	7.16	214 / 803	0%	0	0 / 0
blood vessel	24%	5.54	319 / 1335	0%	0	0 / 0
adrenal gland	7%	1.53	18 / 258	1%	0.02	2 / 230
tonsil	0%	0	0 / 0	2%	0.02	1 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0038065	Biological process	collagen-activated signaling pathway
GO_0007167	Biological process	enzyme-linked receptor protein signaling pathway
GO_0070527	Biological process	platelet aggregation
GO_0038063	Biological process	collagen-activated tyrosine kinase receptor signaling pathway
GO_0002764	Biological process	immune response-regulating signaling pathway
GO_1901731	Biological process	positive regulation of platelet aggregation
GO_0030168	Biological process	platelet activation
GO_0045121	Cellular component	membrane raft
GO_0009986	Cellular component	cell surface
GO_0070062	Cellular component	extracellular exosome
GO_0005886	Cellular component	plasma membrane
GO_0097197	Cellular component	tetraspanin-enriched microdomain
GO_0004888	Molecular function	transmembrane signaling receptor activity
GO_0038023	Molecular function	signaling receptor activity
GO_0038064	Molecular function	collagen receptor activity
GO_0005518	Molecular function	collagen binding
GO_0005515	Molecular function	protein binding
GO_1990782	Molecular function	protein tyrosine kinase binding

Gene name	GP6
Protein name	Platelet glycoprotein VI (GPVI) (Glycoprotein 6) Glycoprotein VI Glycoprotein VI platelet (Platelet glycoprotein VI)
Synonyms	GPVI
Description	FUNCTION: Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2. .
Accessions	ENST00000610746.4 [Q9HCN6-3] ENST00000612096.1 [Q9HCN6-2] ENST00000617356.1 ENST00000610596.1 [Q9HCN6-2] ENST00000622589.4 [Q9HCN6-3] ENST00000310373.7 [Q9HCN6-3] ENST00000616319.1 [Q9HCN6-2] Q9HCN6 ENST00000611436.4 [Q9HCN6-3] ENST00000615407.4 [Q9HCN6-3] ENST00000614889.1 [Q9HCN6-2] ENST00000621278.1 [Q9HCN6-2] Q9HCN5 K7EIW7 ENST00000612862.1 [Q9HCN6-2] ENST00000622653.1 [Q9HCN6-2] ENST00000614662.4 [Q9HCN6-3] ENST00000622279.4 [Q9HCN6-3] ENST00000468239.1 ENST00000613801.1 [Q9HCN6-2] ENST00000616456.1 [Q9HCN6-1] ENST00000417454.5 [Q9HCN6-1] ENST00000619136.4 [Q9HCN6-3] ENST00000612184.4 [Q9HCN6-2] ENST00000333884.2 [Q9HCN6-2] ENST00000613649.4 [Q9HCN6-3] ENST00000617954.4 [Q9HCN6-3]

GP6 report