INTS6 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	33 studies	28% ± 11%	Explore
fibroblast	25 studies	27% ± 13%	Explore
natural killer cell	19 studies	24% ± 10%	Explore
macrophage	14 studies	24% ± 8%	Explore
smooth muscle cell	14 studies	25% ± 12%	Explore
astrocyte	13 studies	34% ± 14%	Explore
pericyte	12 studies	30% ± 12%	Explore
B cell	11 studies	27% ± 8%	Explore
T cell	11 studies	28% ± 15%	Explore
microglial cell	11 studies	29% ± 9%	Explore
mast cell	10 studies	23% ± 6%	Explore
oligodendrocyte	10 studies	27% ± 8%	Explore
endothelial cell of lymphatic vessel	9 studies	26% ± 7%	Explore
glutamatergic neuron	9 studies	37% ± 23%	Explore
CD8-positive, alpha-beta T cell	9 studies	20% ± 5%	Explore
mature NK T cell	8 studies	22% ± 5%	Explore
basal cell	8 studies	32% ± 19%	Explore
oligodendrocyte precursor cell	8 studies	34% ± 12%	Explore
type I pneumocyte	7 studies	20% ± 4%	Explore
naive B cell	7 studies	18% ± 4%	Explore
GABAergic neuron	7 studies	35% ± 18%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	21% ± 7%	Explore
CD4-positive, alpha-beta T cell	7 studies	21% ± 5%	Explore
monocyte	7 studies	26% ± 12%	Explore
adipocyte	7 studies	27% ± 9%	Explore
connective tissue cell	6 studies	23% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	24% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	24% ± 9%	Explore
endothelial cell of vascular tree	6 studies	27% ± 13%	Explore
myeloid cell	6 studies	24% ± 9%	Explore
epithelial cell	6 studies	42% ± 22%	Explore
type II pneumocyte	6 studies	19% ± 4%	Explore
leukocyte	5 studies	25% ± 6%	Explore
capillary endothelial cell	5 studies	22% ± 5%	Explore
myofibroblast cell	5 studies	27% ± 10%	Explore
retina horizontal cell	5 studies	23% ± 4%	Explore
endothelial cell of artery	5 studies	21% ± 6%	Explore
lymphocyte	5 studies	29% ± 10%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	20% ± 4%	Explore
gamma-delta T cell	5 studies	26% ± 8%	Explore
classical monocyte	4 studies	23% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	22% ± 7%	Explore
neuron	4 studies	39% ± 18%	Explore
retinal cone cell	4 studies	24% ± 2%	Explore
adventitial cell	4 studies	17% ± 2%	Explore
dendritic cell	4 studies	25% ± 9%	Explore
mucosal invariant T cell	4 studies	25% ± 7%	Explore
ciliated cell	4 studies	24% ± 8%	Explore
Mueller cell	4 studies	26% ± 6%	Explore
retinal rod cell	4 studies	23% ± 6%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	19% ± 3%	Explore
regulatory T cell	4 studies	19% ± 4%	Explore
plasmacytoid dendritic cell	4 studies	26% ± 9%	Explore
interneuron	4 studies	42% ± 22%	Explore
conventional dendritic cell	3 studies	42% ± 11%	Explore
glomerular endothelial cell	3 studies	50% ± 11%	Explore
kidney loop of Henle epithelial cell	3 studies	19% ± 4%	Explore
amacrine cell	3 studies	22% ± 1%	Explore
retinal bipolar neuron	3 studies	20% ± 0%	Explore
retinal pigment epithelial cell	3 studies	40% ± 8%	Explore
cardiac muscle cell	3 studies	18% ± 3%	Explore
mesothelial cell	3 studies	24% ± 5%	Explore
vein endothelial cell	3 studies	24% ± 8%	Explore
OFF-bipolar cell	3 studies	19% ± 2%	Explore
ON-bipolar cell	3 studies	25% ± 2%	Explore
rod bipolar cell	3 studies	25% ± 4%	Explore
CD4-positive helper T cell	3 studies	25% ± 4%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	25% ± 10%	Explore
hepatocyte	3 studies	46% ± 17%	Explore
muscle cell	3 studies	31% ± 14%	Explore
alveolar macrophage	3 studies	24% ± 8%	Explore
club cell	3 studies	20% ± 3%	Explore
group 3 innate lymphoid cell	3 studies	28% ± 9%	Explore
goblet cell	3 studies	29% ± 16%	Explore
T-helper 17 cell	3 studies	24% ± 5%	Explore
myoepithelial cell	3 studies	33% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	11 studies	33% ± 18%	Explore
lung	8 studies	21% ± 5%	Explore
eye	8 studies	26% ± 12%	Explore
peripheral blood	4 studies	30% ± 10%	Explore
heart	4 studies	18% ± 1%	Explore
kidney	3 studies	18% ± 2%	Explore
uterus	3 studies	30% ± 9%	Explore
breast	3 studies	29% ± 13%	Explore
liver	3 studies	32% ± 10%	Explore
adipose	3 studies	19% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2123.01	1445 / 1445	100%	7.02	183 / 183
lung	100%	2124.92	578 / 578	100%	4.82	1155 / 1155
ovary	100%	2440.97	180 / 180	100%	4.06	430 / 430
thymus	100%	2466.80	653 / 653	100%	4.92	603 / 605
breast	100%	2330.86	459 / 459	100%	6.28	1114 / 1118
pancreas	100%	2362.50	328 / 328	99%	4.14	177 / 178
prostate	100%	2417.74	245 / 245	99%	4.61	499 / 502
uterus	100%	2478.27	170 / 170	99%	4.75	456 / 459
brain	99%	1235.98	2621 / 2642	100%	3.37	703 / 705
bladder	100%	2020.10	21 / 21	99%	4.44	498 / 504
intestine	100%	2075.94	966 / 966	98%	4.88	519 / 527
stomach	100%	1928.48	359 / 359	98%	5.42	281 / 286
skin	100%	2683.01	1809 / 1809	96%	4.80	453 / 472
kidney	100%	1654.43	89 / 89	96%	3.52	863 / 901
adrenal gland	100%	2231.34	258 / 258	96%	3.11	220 / 230
liver	100%	2064.52	226 / 226	92%	2.57	372 / 406
adipose	100%	2501.50	1204 / 1204	0%	0	0 / 0
blood vessel	100%	2131.65	1335 / 1335	0%	0	0 / 0
spleen	100%	1860.69	241 / 241	0%	0	0 / 0
muscle	99%	1028.58	796 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	4.29	44 / 45
peripheral blood	98%	2301.52	906 / 929	0%	0	0 / 0
heart	97%	1329.14	836 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	4.31	28 / 29
eye	0%	0	0 / 0	76%	2.08	61 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0034243	Biological process	regulation of transcription elongation by RNA polymerase II
GO_0016180	Biological process	snRNA processing
GO_0034472	Biological process	snRNA 3'-end processing
GO_0015629	Cellular component	actin cytoskeleton
GO_0032039	Cellular component	integrator complex
GO_0005654	Cellular component	nucleoplasm
GO_0005634	Cellular component	nucleus
GO_0004888	Molecular function	transmembrane signaling receptor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	INTS6
Protein name	Integrator complex subunit 6 Integrator complex subunit 6 (Int6) (DBI-1) (Protein DDX26) (Protein deleted in cancer 1) (DICE1) Integrator complex subunit 6 (cDNA FLJ39377 fis, clone PERIC2000180, highly similar to Homo sapiens DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26 (DDX26), mRNA) (cDNA FLJ45485 fis, clone BRTHA2002661, highly similar to Homo sapiens DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26 (DDX26), mRNA) (cDNA FLJ90465 fis, clone NT2RP3002286, highly similar to Homo sapiens DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26 (DDX26), mRNA)
Synonyms	DBI1 DDX26 DDX26A hCG_29123
Description	FUNCTION: Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex . May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth . .
Accessions	ENST00000483288.5 C9J885 ENST00000483746.1 F8WAV7 ENST00000398119.6 [Q9UL03-3] ENST00000497989.5 Q9UL03 ENST00000490542.5 C9K0V7 ENST00000469430.5 ENST00000485178.5 B3KU90 C9JAV7 C9JVX2 ENST00000491189.5 ENST00000442263.4 [Q9UL03-2] G5E9X1 ENST00000488009.1 ENST00000311234.9 [Q9UL03-1] C9JXP6

INTS6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review