EDA2R report

I. Expression across cell types

Insufficient scRNA-seq data for expression of EDA2R at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EDA2R at tissue level.

III. Associated gene sets

GO_0019221Biological processcytokine-mediated signaling pathway
GO_0008544Biological processepidermis development
GO_0072332Biological processintrinsic apoptotic signaling pathway by p53 class mediator
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0033209Biological processtumor necrosis factor-mediated signaling pathway
GO_0010668Biological processectodermal cell differentiation
GO_0046330Biological processpositive regulation of JNK cascade
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0004888Molecular functiontransmembrane signaling receptor activity
GO_0005031Molecular functiontumor necrosis factor receptor activity
GO_0038023Molecular functionsignaling receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEDA2R
Protein nameTumor necrosis factor receptor superfamily member 27 (X-linked ectodysplasin-A2 receptor) (EDA-A2 receptor)
SynonymsXEDAR
TNFRSF27
UNQ2448/PRO5727/PRO34080
DescriptionFUNCTION: Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6. .

AccessionsENST00000253392.5 [Q9HAV5-2]
ENST00000374719.8 [Q9HAV5-1]
ENST00000451436.6 [Q9HAV5-1]
ENST00000396050.5 [Q9HAV5-2]
Q9HAV5