I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| CD16-negative, CD56-bright natural killer cell, human | 9 studies | 24% ± 7% | |
| gamma-delta T cell | 5 studies | 40% ± 16% | |
| natural killer cell | 5 studies | 28% ± 10% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| CD16-negative, CD56-bright natural killer cell, human | 9 studies | 24% ± 7% | |
| gamma-delta T cell | 5 studies | 40% ± 16% | |
| natural killer cell | 5 studies | 28% ± 10% |
Insufficient scRNA-seq data for expression of KIR2DL4 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 98% | 55.57 | 567 / 578 | 39% | 1.21 | 447 / 1155 |
| spleen | 100% | 376.20 | 241 / 241 | 0% | 0 | 0 / 0 |
| thymus | 88% | 26.98 | 577 / 653 | 10% | 0.19 | 63 / 605 |
| uterus | 38% | 6.23 | 64 / 170 | 50% | 2.43 | 229 / 459 |
| peripheral blood | 86% | 288.25 | 803 / 929 | 0% | 0 | 0 / 0 |
| intestine | 56% | 28.77 | 540 / 966 | 27% | 0.70 | 141 / 527 |
| stomach | 49% | 8.19 | 176 / 359 | 30% | 0.79 | 87 / 286 |
| kidney | 48% | 10.11 | 43 / 89 | 29% | 0.60 | 257 / 901 |
| tonsil | 0% | 0 | 0 / 0 | 69% | 2.37 | 31 / 45 |
| adipose | 67% | 13.77 | 810 / 1204 | 0% | 0 | 0 / 0 |
| liver | 55% | 9.36 | 125 / 226 | 10% | 0.23 | 40 / 406 |
| esophagus | 25% | 3.49 | 357 / 1445 | 39% | 1.30 | 72 / 183 |
| breast | 50% | 8.72 | 231 / 459 | 12% | 0.33 | 139 / 1118 |
| bladder | 29% | 3.71 | 6 / 21 | 26% | 0.89 | 129 / 504 |
| skin | 6% | 0.59 | 100 / 1809 | 43% | 1.99 | 204 / 472 |
| prostate | 44% | 6.66 | 109 / 245 | 3% | 0.05 | 15 / 502 |
| adrenal gland | 40% | 5.59 | 103 / 258 | 4% | 0.09 | 9 / 230 |
| ovary | 17% | 2.46 | 31 / 180 | 21% | 0.49 | 91 / 430 |
| lymph node | 0% | 0 | 0 / 0 | 34% | 0.99 | 10 / 29 |
| blood vessel | 33% | 5.98 | 444 / 1335 | 0% | 0 | 0 / 0 |
| heart | 25% | 3.10 | 219 / 861 | 0% | 0 | 0 / 0 |
| pancreas | 4% | 0.37 | 13 / 328 | 13% | 0.27 | 23 / 178 |
| brain | 5% | 0.70 | 141 / 2642 | 4% | 0.06 | 26 / 705 |
| eye | 0% | 0 | 0 / 0 | 8% | 0.16 | 6 / 80 |
| muscle | 5% | 0.53 | 43 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007165 | Biological process | signal transduction |
| GO_0045953 | Biological process | negative regulation of natural killer cell mediated cytotoxicity |
| GO_2000774 | Biological process | positive regulation of cellular senescence |
| GO_0002729 | Biological process | positive regulation of natural killer cell cytokine production |
| GO_0006968 | Biological process | cellular defense response |
| GO_0002764 | Biological process | immune response-regulating signaling pathway |
| GO_0031901 | Cellular component | early endosome membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0004888 | Molecular function | transmembrane signaling receptor activity |
| GO_0032394 | Molecular function | MHC class Ib receptor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | KIR2DL4 |
| Protein name | KIR2DL4 protein KIR2DL4 protein (Killer cell immunoglobulin-like receptor 2DL4) Killer cell immunoglobulin-like receptor two domains long cytoplasmic tail 4 KIR Natural killer cell recpetor KIR2DL4 (Killer cell immunoglobulin-like receptor 2DL4) (Killer cell immunoglobulin-like receptor two domains long cytoplasmic tail 4) (Killer-cell immunoglobulin-like receptor) Killer-cell immunoglobulin-like receptor Killer cell immunoglobulin-like receptor 2DL4 (CD158 antigen-like family member D) (G9P) (Killer cell inhibitory receptor 103AS) (KIR-103AS) (MHC class I NK cell receptor KIR103AS) (CD antigen CD158d) Killer cell immunoglobulin-like receptor 2DL4 (Killer cell immunoglobulin-like receptor two domains long cytoplasmic tail 4) (Killer-cell immunoglobulin-like receptor) KIR2DL4 (Killer cell immunoglobulin-like receptor) NK cell receptor Natural killer cell inhibitory receptor Truncated NK cell receptor Killer-cell immunoglobulin-like receptor 2DL4 Killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 (Killer cell immunoglobulin-like receptor) Natural killer cell receptor Killer cell immunoglobulin-like receptor 2DL4 Truncated natural killer cell inhibitory receptor KIR2DL4 Killer cell immunoglobulin-like receptor Killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 (Killer cell immunoglobulin-like receptor 2DL4) |
| Synonyms | KIR103AS CD158D KIR-2DL4 LOC112268354 |
| Description | FUNCTION: Receptor for non-classical major histocompatibility class Ib HLA-G molecules. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M). In decidual NK cells, binds peptide-bound HLA-G-B2M complex and triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy . May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells . Upon interaction with peptide-bound HLA-G-B2M, initiates signaling from the endosomal compartment leading to downstream activation of PRKDC-XRCC5 and AKT1, and ultimately triggering NF-kappa-B-dependent pro-inflammatory response . . |
| Accessions | ENST00000673118.1 ENST00000639866.1 [Q99706-3] A0A0G2JPE3 ENST00000638520.3 ENST00000639577.2 [Q99706-3] ENST00000672333.1 Q86WL7 ENST00000620486.4 A3R3E3 A0A376A8S7 ENST00000639635.1 ENST00000671887.1 ENST00000640163.2 [Q99706-6] ENST00000638916.3 ENST00000359085.8 ENST00000611434.4 ENST00000620455.4 A0A0G2JQ13 A0A376A975 ENST00000639294.1 ENST00000638496.3 ENST00000620905.1 ENST00000612660.4 ENST00000620961.1 ENST00000610911.4 A0A1W2PQV0 ENST00000614599.1 A0A0G2JPS9 ENST00000622322.4 ENST00000621773.3 ENST00000617052.1 ENST00000638839.1 ENST00000611244.3 ENST00000672205.1 A0A0G2JPN7 A0A6G6CYW4 ENST00000614253.1 A0A0G2JLM0 ENST00000639536.2 ENST00000621932.4 ENST00000673111.1 ENST00000615139.4 ENST00000612879.2 ENST00000645751.1 ENST00000619043.2 A0A0C4ZNX8 ENST00000638887.3 ENST00000639863.3 ENST00000672172.1 ENST00000639740.1 [Q99706-6] ENST00000671768.1 ENST00000622350.3 ENST00000620484.4 E0X065 ENST00000638613.1 ENST00000622348.4 Q99706 ENST00000640340.2 ENST00000640775.3 ENST00000673425.1 ENST00000619877.2 Q86U48 ENST00000622882.4 ENST00000621258.3 Q5IH82 A0A0G2JNZ6 K7RE46 A0A1B5BA15 ENST00000622365.2 ENST00000640814.1 [Q99706-3] ENST00000619637.4 ENST00000672798.1 A0A0B4J1S6 A0A376A8L2 ENST00000610492.4 ENST00000638811.1 ENST00000673454.1 A0A376A8Z1 A0A376A929 A8MT18 A8W794 ENST00000672435.1 ENST00000346587.8 ENST00000640727.3 ENST00000639814.3 A0A376A8Y3 ENST00000671736.1 ENST00000640612.1 E0X068 ENST00000640118.3 ENST00000622437.4 ENST00000616354.4 ENST00000621031.4 A8W793 K7QUT1 ENST00000639915.1 E7EST5 ENST00000672220.1 ENST00000639882.1 A0A0G2JPG6 ENST00000345540.10 [Q99706-3] ENST00000614680.4 [Q99706-3] ENST00000639792.3 ENST00000673527.1 ENST00000639735.2 A0A0G2JLN0 A0A0G2JNK6 A0A1B5BA12 ENST00000638388.1 A0A7D5C391 ENST00000613629.4 ENST00000639569.1 ENST00000611437.4 ENST00000640142.1 A0A376A8K3 ENST00000612389.4 ENST00000618567.1 Q5IHW6 ENST00000610662.3 ENST00000673405.1 E0X069 ENST00000640693.2 ENST00000640883.1 ENST00000672217.1 ENST00000612865.4 ENST00000639768.1 A0A0G2JLM4 ENST00000618297.1 ENST00000619980.4 A0A5K1U1N8 ENST00000638248.1 [Q99706-4] A0A0C4ZMX4 A0A142DV54 Q32WE1 A0A0U5KR66 ENST00000638239.2 ENST00000638428.2 ENST00000640009.3 ENST00000640008.2 A0A0G2JMF5 ENST00000612364.4 A0A0C4ZQY0 ENST00000612573.1 A0A5K1V8C4 ENST00000616375.4 ENST00000671731.1 ENST00000671930.1 ENST00000614339.4 ENST00000619195.1 A0A6G6CYU5 ENST00000396289.5 ENST00000673457.1 ENST00000638343.3 ENST00000638748.2 ENST00000639039.3 ENST00000615970.1 Q32WE2 A0A0G2JNG7 ENST00000640629.1 Q96L48 Q96L49 ENST00000640045.1 Q5IH87 ENST00000618501.4 ENST00000640844.3 ENST00000639460.1 [Q99706-6] ENST00000638731.3 ENST00000613824.1 ENST00000672311.1 ENST00000613149.4 A0A2R4K3A7 ENST00000639352.1 Q96L47 ENST00000639684.2 A0A376A8K5 A0A0C4ZR19 ENST00000639624.1 ENST00000673356.1 K7QUS9 ENST00000615232.4 [Q99706-6] ENST00000621002.4 ENST00000640591.1 ENST00000622255.4 A0A2R4K399 ENST00000357494.8 [Q99706-4] ENST00000673616.1 ENST00000640795.1 ENST00000638897.1 [Q99706-4] A7YL15 ENST00000640214.1 ENST00000673508.1 ENST00000616667.1 A0A142DV53 ENST00000638297.1 [Q99706-6] ENST00000672643.1 A0A0G2JNE8 ENST00000638801.3 A0A0G2JMV5 ENST00000639533.1 [Q99706-6] ENST00000639572.1 ENST00000640447.3 ENST00000640596.1 ENST00000672677.1 ENST00000618607.4 ENST00000640424.2 ENST00000672182.1 ENST00000639468.1 E0X067 A0A142DV56 Q5IHW5 ENST00000619882.4 ENST00000614653.1 Q32WD9 A0A5J6VQI0 A0A0G2JLZ7 ENST00000620369.1 ENST00000639366.1 ENST00000639076.2 ENST00000640090.1 ENST00000396293.5 [Q99706-6] ENST00000613442.4 A0A6G6CYW0 ENST00000614379.1 ENST00000638563.2 [Q99706-4] ENST00000620007.4 ENST00000640895.2 ENST00000621182.3 [Q99706-3] ENST00000639597.3 ENST00000639830.1 ENST00000613053.1 A0A0G2JN69 ENST00000618358.1 ENST00000638247.1 ENST00000610608.1 Q86WL6 ENST00000640764.1 ENST00000615243.4 [Q99706-4] ENST00000671782.1 A0A0G2JMD1 ENST00000638601.3 ENST00000641000.1 ENST00000621636.4 Q32WE0 Q86VF1 ENST00000621484.4 ENST00000618013.1 ENST00000639207.1 ENST00000639619.1 A0A0G2JP28 ENST00000619868.4 A0A7D5CA75 ENST00000619946.1 ENST00000640434.2 A0A1B5BA14 A0A0G2JNI1 ENST00000616384.4 [Q99706-3] ENST00000640937.3 ENST00000618955.4 ENST00000639400.2 ENST00000639506.2 ENST00000619802.1 ENST00000619848.1 ENST00000638231.1 [Q99706-6] Q8N736 ENST00000639911.2 ENST00000638493.1 ENST00000639403.1 Q5IHW9 ENST00000614427.1 ENST00000618640.1 ENST00000672459.1 A0A6G6CZ72 ENST00000638339.3 A0A0G2JMQ9 ENST00000615396.4 ENST00000639407.2 A0A7D4XZ23 A0A0G2JQ39 ENST00000614619.4 ENST00000611022.4 [Q99706-3] |
