GPR158 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001956Biological processpositive regulation of neurotransmitter secretion
GO_0007420Biological processbrain development
GO_0050890Biological processcognition
GO_0050807Biological processregulation of synapse organization
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0008277Biological processregulation of G protein-coupled receptor signaling pathway
GO_0072659Biological processprotein localization to plasma membrane
GO_0042995Cellular componentcell projection
GO_0005886Cellular componentplasma membrane
GO_0042734Cellular componentpresynaptic membrane
GO_0045211Cellular componentpostsynaptic membrane
GO_0005634Cellular componentnucleus
GO_0004888Molecular functiontransmembrane signaling receptor activity
GO_0008047Molecular functionenzyme activator activity
GO_0160079Molecular functionG protein-coupled glycine receptor activity

IV. Literature review

[source]
Gene nameGPR158
Protein nameG protein-coupled receptor 158
Metabotropic glycine receptor (mGlyR) (G-protein coupled receptor 158)
SynonymsKIAA1136
DescriptionFUNCTION: Metabotropic receptor for glycine that controls synapse formation and function in the brain . Acts as an atypical G-protein coupled receptor that recruits and regulates the RGS7-GNB5 complex instead of activating G proteins . In absence of glycine ligand, promotes the GTPase activator activity of RGS7, increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form . Glycine-binding changes the conformation of the intracellular surface, inhibiting the GTPase activator activity of the RGS7-GNB5 complex, promoting G protein alpha subunits into their active GTP-bound form and regulating cAMP levels . Also able to bind taurine, a compound closely related to glycine, but with a two-fold lower affinity . Glycine receptor-dependent regulation of cAMP controls key ion channels, kinases and neurotrophic factors involved in neuronal excitability and synaptic transmission . Plays a pivotal role in regulating mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex (By similarity). Also involved in spatial learning by regulating hippocampal CA1 neuronal excitability (By similarity). Acts as a synaptic organizer in the hippocampus, required for proper mossy fiber-CA3 neurocircuitry establishment, structure and function: induces presynaptic differentiation in contacting axons via its interaction with GPC4 (By similarity). In addition to glycine, may also act as a receptor for osteocalcin (BGLAP) hormone: osteocalcin-binding initiates a signaling response that prevents neuronal apoptosis in the hippocampus and regulates the synthesis of neurotransmitters (By similarity). .

AccessionsENST00000650135.1
A0A3B3IUC3
Q5T848
ENST00000376351.4