MRGPRX1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MRGPRX1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MRGPRX1 at tissue level.

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_1902349Biological processresponse to chloroquine
GO_0006953Biological processacute-phase response
GO_0007166Biological processcell surface receptor signaling pathway
GO_0009986Cellular componentcell surface
GO_0005886Cellular componentplasma membrane
GO_0004888Molecular functiontransmembrane signaling receptor activity
GO_0004930Molecular functionG protein-coupled receptor activity

IV. Literature review

[source]
Gene nameMRGPRX1
Protein nameMas-related G-protein-coupled receptor member X1
MAS-related GPR member X1
MAS-related GPR, member X1 (Mas-related G protein-coupled receptor G2)
Mas-related G-protein coupled receptor member X1 (Sensory neuron-specific G-protein coupled receptor 3/4)
SynonymshCG_1991280
SNSR4
MRGX1
MGRG2
SNSR3
DescriptionFUNCTION: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine-independent manner. .

AccessionsQ96LB2
ENST00000526914
ENST00000302797.4
W8W3P5
ENST00000526914.2
A0A494C1K4
B5B0C6