GABBR2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
glutamatergic neuron	13 studies	66% ± 26%	Explore
GABAergic neuron	10 studies	60% ± 28%	Explore
interneuron	7 studies	54% ± 35%	Explore
neuron	5 studies	37% ± 14%	Explore
granule cell	4 studies	48% ± 22%	Explore
oligodendrocyte precursor cell	4 studies	21% ± 2%	Explore
retinal ganglion cell	4 studies	30% ± 13%	Explore
retinal bipolar neuron	3 studies	21% ± 5%	Explore
GABAergic interneuron	3 studies	67% ± 14%	Explore
astrocyte	3 studies	46% ± 22%	Explore
amacrine cell	3 studies	24% ± 6%	Explore
GABAergic amacrine cell	3 studies	25% ± 6%	Explore
OFF-bipolar cell	3 studies	36% ± 8%	Explore
rod bipolar cell	3 studies	27% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	42% ± 25%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	94%	6929.67	2472 / 2642	96%	56.38	680 / 705
thymus	63%	371.09	409 / 653	81%	28.69	490 / 605
ureter	0%	0	0 / 0	100%	2.63	1 / 1
adrenal gland	54%	441.61	140 / 258	40%	7.69	92 / 230
bladder	0%	0	0 / 21	27%	6.11	138 / 504
skin	18%	334.81	331 / 1809	3%	0.29	15 / 472
lung	7%	57.54	40 / 578	12%	1.21	144 / 1155
ovary	0%	0	0 / 180	18%	1.53	76 / 430
liver	0%	0	0 / 226	12%	1.28	49 / 406
uterus	1%	2.13	1 / 170	11%	3.79	52 / 459
breast	0%	0.78	1 / 459	11%	1.21	121 / 1118
pancreas	1%	2.25	2 / 328	7%	1.18	12 / 178
tonsil	0%	0	0 / 0	7%	0.87	3 / 45
stomach	0%	1.16	1 / 359	5%	1.17	15 / 286
esophagus	0%	1.17	3 / 1445	3%	0.28	6 / 183
eye	0%	0	0 / 0	3%	0.26	2 / 80
kidney	0%	0	0 / 89	2%	0.10	21 / 901
heart	2%	7.49	18 / 861	0%	0	0 / 0
prostate	0%	0	0 / 245	1%	0.07	7 / 502
intestine	0%	0.71	2 / 966	1%	0.08	6 / 527
adipose	0%	0.26	1 / 1204	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
blood vessel	0%	0	0 / 1335	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0

III. Associated gene sets

GO_0007194	Biological process	negative regulation of adenylate cyclase activity
GO_0051932	Biological process	synaptic transmission, GABAergic
GO_0007214	Biological process	gamma-aminobutyric acid signaling pathway
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0007193	Biological process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO_0007268	Biological process	chemical synaptic transmission
GO_0150099	Biological process	neuron-glial cell signaling
GO_0038039	Cellular component	G protein-coupled receptor heterodimeric complex
GO_1902712	Cellular component	G protein-coupled GABA receptor complex
GO_0005886	Cellular component	plasma membrane
GO_1902710	Cellular component	GABA receptor complex
GO_0043005	Cellular component	neuron projection
GO_0005737	Cellular component	cytoplasm
GO_0045211	Cellular component	postsynaptic membrane
GO_0004888	Molecular function	transmembrane signaling receptor activity
GO_0046982	Molecular function	protein heterodimerization activity
GO_0004965	Molecular function	G protein-coupled GABA receptor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	GABBR2
Protein name	Gamma-aminobutyric acid (GABA) B receptor, 2, isoform CRA_b (Gamma-aminobutyric acid B receptor 2) Gamma-aminobutyric acid type B receptor subunit 2 (GABA-B receptor 2) (GABA-B-R2) (GABA-BR2) (GABABR2) (Gb2) (G-protein coupled receptor 51) (HG20) Gamma-aminobutyric acid type B receptor subunit 2
Synonyms	hCG_1817807 GPR51 GPRC3B
Description	FUNCTION: Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 . Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins . Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase . Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis . Plays a critical role in the fine-tuning of inhibitory synaptic transmission . Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials . Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). .
Accessions	ENST00000637717.1 ENST00000634457.1 A0A1B0GW60 A0A0U1RR59 H9NIL8 ENST00000259455.4 O75899

GABBR2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review