Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 9089.59 | 2638 / 2642 | 99% | 18.68 | 699 / 705 |
| thymus | 100% | 3312.06 | 652 / 653 | 98% | 12.46 | 594 / 605 |
| kidney | 100% | 4666.39 | 89 / 89 | 98% | 15.93 | 880 / 901 |
| prostate | 98% | 2807.96 | 239 / 245 | 100% | 10.25 | 500 / 502 |
| lung | 99% | 3377.60 | 573 / 578 | 98% | 12.40 | 1132 / 1155 |
| stomach | 93% | 2114.16 | 335 / 359 | 98% | 10.39 | 281 / 286 |
| ovary | 95% | 1665.69 | 171 / 180 | 96% | 8.97 | 412 / 430 |
| adrenal gland | 100% | 2784.81 | 258 / 258 | 86% | 7.02 | 198 / 230 |
| uterus | 80% | 1475.87 | 136 / 170 | 96% | 11.13 | 440 / 459 |
| intestine | 74% | 2544.48 | 715 / 966 | 99% | 11.47 | 524 / 527 |
| esophagus | 70% | 2369.72 | 1006 / 1445 | 96% | 11.44 | 175 / 183 |
| bladder | 62% | 1867.95 | 13 / 21 | 96% | 9.72 | 483 / 504 |
| pancreas | 57% | 790.41 | 187 / 328 | 98% | 11.50 | 175 / 178 |
| breast | 51% | 897.17 | 233 / 459 | 98% | 10.06 | 1097 / 1118 |
| skin | 72% | 2608.53 | 1299 / 1809 | 74% | 7.55 | 350 / 472 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 29.42 | 29 / 29 |
| muscle | 100% | 8078.42 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 11212.76 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 15.09 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 9.77 | 1 / 1 |
| peripheral blood | 99% | 13233.46 | 921 / 929 | 0% | 0 | 0 / 0 |
| heart | 78% | 1391.15 | 669 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 74% | 3.90 | 59 / 80 |
| adipose | 53% | 906.65 | 639 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 33% | 496.09 | 446 / 1335 | 0% | 0 | 0 / 0 |
| liver | 6% | 74.62 | 14 / 226 | 22% | 1.39 | 91 / 406 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0061430 | Biological process | bone trabecula morphogenesis |
| GO_1905704 | Biological process | positive regulation of inhibitory synapse assembly |
| GO_0043547 | Biological process | positive regulation of GTPase activity |
| GO_0001755 | Biological process | neural crest cell migration |
| GO_0048814 | Biological process | regulation of dendrite morphogenesis |
| GO_0007162 | Biological process | negative regulation of cell adhesion |
| GO_0007155 | Biological process | cell adhesion |
| GO_0001934 | Biological process | positive regulation of protein phosphorylation |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0050919 | Biological process | negative chemotaxis |
| GO_0050732 | Biological process | negative regulation of peptidyl-tyrosine phosphorylation |
| GO_0006955 | Biological process | immune response |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_0050731 | Biological process | positive regulation of peptidyl-tyrosine phosphorylation |
| GO_0031344 | Biological process | regulation of cell projection organization |
| GO_0045668 | Biological process | negative regulation of osteoblast differentiation |
| GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0008360 | Biological process | regulation of cell shape |
| GO_0070486 | Biological process | leukocyte aggregation |
| GO_0071526 | Biological process | semaphorin-plexin signaling pathway |
| GO_0048672 | Biological process | positive regulation of collateral sprouting |
| GO_0035025 | Biological process | positive regulation of Rho protein signal transduction |
| GO_0043931 | Biological process | ossification involved in bone maturation |
| GO_0007411 | Biological process | axon guidance |
| GO_0005615 | Cellular component | extracellular space |
| GO_0002116 | Cellular component | semaphorin receptor complex |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0038023 | Molecular function | signaling receptor activity |
| GO_0048018 | Molecular function | receptor ligand activity |
| GO_0004888 | Molecular function | transmembrane signaling receptor activity |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0030215 | Molecular function | semaphorin receptor binding |
| GO_0045499 | Molecular function | chemorepellent activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | SEMA4D |
| Protein name | Semaphorin-4D Semaphorin-4D (A8) (BB18) (GR3) (CD antigen CD100) Semaphorin 4D SEMA4D variant protein |
| Synonyms | C9orf164 protein CD100 variant SEMAJ |
| Description | FUNCTION: Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling . Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA . Promotes the migration of cerebellar granule cells . Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) . Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway . . |
| Accessions | Q92854 F5H044 ENST00000537934.5 ENST00000418828.1 ENST00000356444.6 [Q92854-1] Q4LE41 ENST00000420987.5 [Q92854-2] ENST00000422704.7 [Q92854-1] ENST00000450295.5 [Q92854-1] C9JFP1 C9JYS7 ENST00000339861.8 [Q92854-2] ENST00000420101 A0A0C4DG45 ENST00000420681.6 ENST00000433650.5 ENST00000455551.6 [Q92854-2] ENST00000429836.5 ENST00000438547.6 [Q92854-1] C9JD54 ENST00000540475.5 E9PFD9 |
