SORL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045053Biological processprotein retention in Golgi apparatus
GO_1900168Biological processpositive regulation of glial cell-derived neurotrophic factor production
GO_1904179Biological processpositive regulation of adipose tissue development
GO_0007218Biological processneuropeptide signaling pathway
GO_0010897Biological processnegative regulation of triglyceride catabolic process
GO_0006622Biological processprotein targeting to lysosome
GO_0006898Biological processreceptor-mediated endocytosis
GO_1902955Biological processpositive regulation of early endosome to recycling endosome transport
GO_1902430Biological processnegative regulation of amyloid-beta formation
GO_0006892Biological processpost-Golgi vesicle-mediated transport
GO_0002024Biological processdiet induced thermogenesis
GO_0038020Biological processinsulin receptor recycling
GO_0031333Biological processnegative regulation of protein-containing complex assembly
GO_1902953Biological processpositive regulation of ER to Golgi vesicle-mediated transport
GO_0099638Biological processendosome to plasma membrane protein transport
GO_0030514Biological processnegative regulation of BMP signaling pathway
GO_1902966Biological processpositive regulation of protein localization to early endosome
GO_1902997Biological processnegative regulation of neurofibrillary tangle assembly
GO_0006605Biological processprotein targeting
GO_1990845Biological processadaptive thermogenesis
GO_0014910Biological processregulation of smooth muscle cell migration
GO_0034067Biological processprotein localization to Golgi apparatus
GO_0070863Biological processpositive regulation of protein exit from endoplasmic reticulum
GO_0045732Biological processpositive regulation of protein catabolic process
GO_1902992Biological processnegative regulation of amyloid precursor protein catabolic process
GO_0046628Biological processpositive regulation of insulin receptor signaling pathway
GO_2001137Biological processpositive regulation of endocytic recycling
GO_0016477Biological processcell migration
GO_0050768Biological processnegative regulation of neurogenesis
GO_0051604Biological processprotein maturation
GO_0005615Cellular componentextracellular space
GO_0005886Cellular componentplasma membrane
GO_0005641Cellular componentnuclear envelope lumen
GO_0031985Cellular componentGolgi cisterna
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0055037Cellular componentrecycling endosome
GO_0005769Cellular componentearly endosome
GO_0031901Cellular componentearly endosome membrane
GO_0055038Cellular componentrecycling endosome membrane
GO_0070062Cellular componentextracellular exosome
GO_0005794Cellular componentGolgi apparatus
GO_0043025Cellular componentneuronal cell body
GO_0005802Cellular componenttrans-Golgi network
GO_0009986Cellular componentcell surface
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005771Cellular componentmultivesicular body
GO_0010008Cellular componentendosome membrane
GO_0030658Cellular componenttransport vesicle membrane
GO_0005768Cellular componentendosome
GO_0032585Cellular componentmultivesicular body membrane
GO_0097356Cellular componentperinucleolar compartment
GO_0004888Molecular functiontransmembrane signaling receptor activity
GO_0001540Molecular functionamyloid-beta binding
GO_0031267Molecular functionsmall GTPase binding
GO_0019828Molecular functionaspartic-type endopeptidase inhibitor activity
GO_0042923Molecular functionneuropeptide binding
GO_0005041Molecular functionlow-density lipoprotein particle receptor activity
GO_0030169Molecular functionlow-density lipoprotein particle binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSORL1
Protein nameSortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA)
Alternative protein SORL1
Sortilin related receptor 1
SynonymsC11orf32
DescriptionFUNCTION: Sorting receptor that directs several proteins to their correct location within the cell (Probable). Along with AP-1 complex, involved Golgi apparatus - endosome sorting . Sorting receptor for APP, regulating its intracellular trafficking and processing into amyloidogenic-beta peptides. Retains APP in the trans-Golgi network, hence preventing its transit through late endosomes where amyloid beta peptides Abeta40 and Abeta42 are generated . May also sort newly produced amyloid-beta peptides to lysosomes for catabolism . Does not affect APP trafficking from the endoplasmic reticulum to Golgi compartments . Sorting receptor for the BDNF receptor NTRK2/TRKB that facilitates NTRK2 trafficking between synaptic plasma membranes, postsynaptic densities and cell soma, hence positively regulates BDNF signaling by controlling the intracellular location of its receptor . Sorting receptor for GDNF that promotes GDNF regulated, but not constitutive secretion . Sorting receptor for the GDNF-GFRA1 complex, directing it from the cell surface to endosomes. GDNF is then targeted to lysosomes and degraded, while its receptor GFRA1 recycles back to the cell membrane, resulting in a GDNF clearance pathway. The SORL1-GFRA1 complex further targets RET for endocytosis, but not for degradation, affecting GDNF-induced neurotrophic activities . Sorting receptor for ERBB2/HER2. Regulates ERBB2 subcellular distribution by promoting its recycling after internalization from endosomes back to the plasma membrane, hence stimulating phosphoinositide 3-kinase (PI3K)-dependent ERBB2 signaling. In ERBB2-dependent cancer cells, promotes cell proliferation . Sorting receptor for lipoprotein lipase LPL. Promotes LPL localization to endosomes and later to the lysosomes, leading to degradation of newly synthesized LPL . Potential sorting receptor for APOA5, inducing APOA5 internalization to early endosomes, then to late endosomes, wherefrom a portion is sent to lysosomes and degradation, another portion is sorted to the trans-Golgi network . Sorting receptor for the insulin receptor INSR. Promotes recycling of internalized INSR via the Golgi apparatus back to the cell surface, thereby preventing lysosomal INSR catabolism, increasing INSR cell surface expression and strengthening insulin signal reception in adipose tissue. Does not affect INSR internalization . Plays a role in renal ion homeostasis, controlling the phospho-regulation of SLC12A1/NKCC2 by STK39/SPAK kinase and PPP3CB/calcineurin A beta phosphatase, possibly through intracellular sorting of STK39 and PPP3CB (By similarity). Stimulates, via the N-terminal ectodomain, the proliferation and migration of smooth muscle cells, possibly by increasing cell surface expression of the urokinase receptor uPAR/PLAUR. This may promote extracellular matrix proteolysis and hence facilitate cell migration . By acting on the migration of intimal smooth muscle cells, may accelerate intimal thickening following vascular injury . Promotes adhesion of monocytes . Stimulates proliferation and migration of monocytes/macrophages (By similarity). Through its action on intimal smooth muscle cells and macrophages, may accelerate intimal thickening and macrophage foam cell formation in the process of atherosclerosis (By similarity). Regulates hypoxia-enhanced adhesion of hematopoietic stem and progenitor cells to the bone marrow stromal cells via a PLAUR-mediated pathway. This function is mediated by the N-terminal ectodomain . Metabolic regulator, which functions to maintain the adequate balance between lipid storage and oxidation in response to changing environmental conditions, such as temperature and diet. The N-terminal ectodomain negatively regulates adipose tissue energy expenditure, acting through the inhibition the BMP/Smad pathway (By similarity). May regulate signaling by the heterodimeric neurotrophic cytokine CLCF1-CRLF1 bound to the CNTFR receptor by promoting the endocytosis of the tripartite complex CLCF1-CRLF1-CNTFR and lysosomal degradation . May regulate IL6 signaling, decreasing cis signaling, possibly by interfering with IL6-binding to membrane-bound IL6R, while up-regulating trans signaling via soluble IL6R . .

AccessionsENST00000525532.5
Q92673
L8EA23
ENST00000527934.1
E9PP43
ENST00000534286.5
E9PKB0
E9PS32
E9PPB3
ENST00000260197.12
ENST00000532694.5