TLR5 | OmnibusX

Name	Number of supported studies	Average coverage
microglial cell	6 studies	25% ± 9%	Explore
macrophage	5 studies	21% ± 7%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of TLR5 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	99%	740.17	242 / 245	98%	4.15	492 / 502
breast	95%	654.46	438 / 459	99%	9.18	1112 / 1118
ovary	100%	2126.78	180 / 180	94%	4.24	406 / 430
lung	98%	715.19	566 / 578	95%	5.23	1096 / 1155
thymus	97%	411.30	631 / 653	96%	3.98	581 / 605
pancreas	95%	343.47	312 / 328	97%	5.98	173 / 178
esophagus	98%	709.97	1410 / 1445	90%	4.40	165 / 183
kidney	99%	421.66	88 / 89	87%	3.40	781 / 901
uterus	91%	368.84	155 / 170	86%	5.09	394 / 459
bladder	100%	482.24	21 / 21	72%	2.40	363 / 504
stomach	96%	405.44	345 / 359	65%	1.82	185 / 286
intestine	94%	338.67	912 / 966	54%	1.52	285 / 527
brain	50%	131.10	1333 / 2642	80%	2.72	563 / 705
skin	71%	330.11	1276 / 1809	55%	1.26	261 / 472
adrenal gland	88%	252.45	228 / 258	37%	0.72	84 / 230
liver	48%	94.80	109 / 226	52%	2.02	212 / 406
spleen	99%	979.11	239 / 241	0%	0	0 / 0
adipose	96%	484.89	1154 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	7.16	43 / 45
blood vessel	88%	297.77	1174 / 1335	0%	0	0 / 0
heart	82%	234.42	707 / 861	0%	0	0 / 0
peripheral blood	78%	4091.74	722 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	62%	1.56	18 / 29
eye	0%	0	0 / 0	34%	0.51	27 / 80
muscle	19%	30.55	149 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0034146	Biological process	toll-like receptor 5 signaling pathway
GO_0002224	Biological process	toll-like receptor signaling pathway
GO_0006954	Biological process	inflammatory response
GO_0071260	Biological process	cellular response to mechanical stimulus
GO_0032757	Biological process	positive regulation of interleukin-8 production
GO_0045087	Biological process	innate immune response
GO_0005886	Cellular component	plasma membrane
GO_0004888	Molecular function	transmembrane signaling receptor activity
GO_0038023	Molecular function	signaling receptor activity
GO_0038187	Molecular function	pattern recognition receptor activity
GO_0005515	Molecular function	protein binding
GO_0005149	Molecular function	interleukin-1 receptor binding

Gene name	TLR5
Protein name	Toll-like receptor 5 (Toll/interleukin-1 receptor-like protein 3) Toll like receptor 5 Toll-like receptor 5
Synonyms	TIL3
Description	FUNCTION: Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response . Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota . Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response . Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life (By similarity). .
Accessions	B9VJ69 B9VJ68 ENST00000407096.6 ENST00000540964.5 D1CS84 D1CS82 B1AZ06 D1CS83 B9VJ70 D1CS90 D1CS89 B9VJ77 B9VJ65 B9VJ73 D1CS87 D1CS88 A0A2R8Y7Z4 A0A2R8Y4Q2 D1CS79 B9VJ75 B9VJ72 O60602 ENST00000645434.1 ENST00000642603.2 D1CS85 B9VJ61

TLR5 report