I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| B cell | 6 studies | 23% ± 7% | |
| naive B cell | 5 studies | 26% ± 11% | |
| memory B cell | 4 studies | 27% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| B cell | 6 studies | 23% ± 7% | |
| naive B cell | 5 studies | 26% ± 11% | |
| memory B cell | 4 studies | 27% ± 5% |
Insufficient scRNA-seq data for expression of CR2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 71% | 33.22 | 413 / 578 | 67% | 8.75 | 771 / 1155 |
| kidney | 93% | 197.00 | 83 / 89 | 10% | 0.62 | 89 / 901 |
| stomach | 53% | 32.27 | 189 / 359 | 50% | 7.12 | 144 / 286 |
| intestine | 59% | 851.31 | 566 / 966 | 43% | 6.47 | 229 / 527 |
| spleen | 100% | 10472.24 | 241 / 241 | 0% | 0 | 0 / 0 |
| thymus | 62% | 208.16 | 403 / 653 | 35% | 6.53 | 211 / 605 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 84.25 | 28 / 29 |
| peripheral blood | 94% | 2252.41 | 875 / 929 | 0% | 0 | 0 / 0 |
| pancreas | 34% | 5.48 | 110 / 328 | 49% | 25.47 | 88 / 178 |
| breast | 43% | 15.27 | 196 / 459 | 27% | 3.58 | 304 / 1118 |
| esophagus | 28% | 25.34 | 401 / 1445 | 40% | 5.54 | 74 / 183 |
| bladder | 33% | 19.38 | 7 / 21 | 32% | 3.69 | 161 / 504 |
| tonsil | 0% | 0 | 0 / 0 | 53% | 7.17 | 24 / 45 |
| ovary | 18% | 6.73 | 32 / 180 | 28% | 1.00 | 122 / 430 |
| skin | 16% | 3.51 | 282 / 1809 | 30% | 11.67 | 140 / 472 |
| prostate | 24% | 49.68 | 58 / 245 | 15% | 1.02 | 76 / 502 |
| liver | 31% | 7.31 | 69 / 226 | 8% | 1.69 | 33 / 406 |
| muscle | 38% | 13.15 | 309 / 803 | 0% | 0 | 0 / 0 |
| brain | 31% | 6.69 | 807 / 2642 | 1% | 0.04 | 5 / 705 |
| uterus | 11% | 1.81 | 19 / 170 | 19% | 1.43 | 86 / 459 |
| adipose | 28% | 19.61 | 341 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 14% | 15.37 | 183 / 1335 | 0% | 0 | 0 / 0 |
| adrenal gland | 7% | 2.14 | 19 / 258 | 1% | 0.03 | 2 / 230 |
| heart | 8% | 2.10 | 66 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.02 | 1 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006957 | Biological process | complement activation, alternative pathway |
| GO_0045959 | Biological process | negative regulation of complement activation, classical pathway |
| GO_0006955 | Biological process | immune response |
| GO_0046718 | Biological process | symbiont entry into host cell |
| GO_0006958 | Biological process | complement activation, classical pathway |
| GO_0042100 | Biological process | B cell proliferation |
| GO_0002456 | Biological process | T cell mediated immunity |
| GO_0030183 | Biological process | B cell differentiation |
| GO_0002430 | Biological process | complement receptor mediated signaling pathway |
| GO_0005615 | Cellular component | extracellular space |
| GO_0043235 | Cellular component | receptor complex |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0003677 | Molecular function | DNA binding |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0004888 | Molecular function | transmembrane signaling receptor activity |
| GO_0034987 | Molecular function | immunoglobulin receptor binding |
| GO_0004875 | Molecular function | complement receptor activity |
| GO_0001848 | Molecular function | complement binding |
| GO_0001618 | Molecular function | virus receptor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | CR2 |
| Protein name | Complement C3d receptor 2 Complement receptor type 2 (Cr2) (Complement C3d receptor) (Epstein-Barr virus receptor) (EBV receptor) (CD antigen CD21) Complement receptor |
| Synonyms | C3DR |
| Description | FUNCTION: Receptor for complement C3, for the Epstein-Barr virus on human B-cells and T-cells and for HNRNPU . Participates in B lymphocytes activation . .; FUNCTION: (Microbial infection) Acts as a receptor for Epstein-Barr virus. . |
| Accessions | ENST00000367058.7 [P20023-1] A0A1W2PPV2 A0A8V8TNI2 ENST00000367057.8 [P20023-3] ENST00000699640.1 Q08578 ENST00000699621.1 ENST00000699620.1 P20023 Q5SR47 ENST00000367059.3 ENST00000640301.1 A0A8V8TQA3 A0A8V8TPX6 |
