CD44 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	43 studies	49% ± 23%	Explore
CD8-positive, alpha-beta T cell	41 studies	48% ± 15%	Explore
natural killer cell	40 studies	41% ± 18%	Explore
T cell	38 studies	49% ± 15%	Explore
fibroblast	37 studies	42% ± 19%	Explore
B cell	35 studies	42% ± 13%	Explore
CD4-positive, alpha-beta T cell	35 studies	55% ± 15%	Explore
mast cell	33 studies	66% ± 21%	Explore
classical monocyte	29 studies	69% ± 17%	Explore
conventional dendritic cell	29 studies	50% ± 20%	Explore
regulatory T cell	29 studies	60% ± 13%	Explore
non-classical monocyte	27 studies	65% ± 17%	Explore
monocyte	26 studies	60% ± 19%	Explore
dendritic cell	25 studies	48% ± 19%	Explore
smooth muscle cell	23 studies	33% ± 12%	Explore
basal cell	22 studies	43% ± 15%	Explore
pericyte	21 studies	39% ± 20%	Explore
memory B cell	20 studies	47% ± 14%	Explore
gamma-delta T cell	19 studies	48% ± 15%	Explore
plasmacytoid dendritic cell	19 studies	36% ± 12%	Explore
mature NK T cell	19 studies	47% ± 15%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	53% ± 14%	Explore
naive B cell	18 studies	40% ± 13%	Explore
myeloid cell	18 studies	48% ± 21%	Explore
CD16-negative, CD56-bright natural killer cell, human	17 studies	58% ± 16%	Explore
plasma cell	16 studies	32% ± 11%	Explore
mucosal invariant T cell	16 studies	52% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	33% ± 16%	Explore
astrocyte	16 studies	38% ± 16%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	51% ± 17%	Explore
epithelial cell	15 studies	35% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	13 studies	54% ± 15%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	56% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	55% ± 16%	Explore
type II pneumocyte	12 studies	57% ± 16%	Explore
neutrophil	11 studies	52% ± 19%	Explore
connective tissue cell	11 studies	39% ± 19%	Explore
myofibroblast cell	11 studies	31% ± 8%	Explore
innate lymphoid cell	10 studies	61% ± 18%	Explore
leukocyte	10 studies	49% ± 17%	Explore
secretory cell	9 studies	29% ± 8%	Explore
alveolar macrophage	8 studies	72% ± 10%	Explore
type I pneumocyte	8 studies	34% ± 9%	Explore
T follicular helper cell	8 studies	56% ± 9%	Explore
club cell	8 studies	30% ± 8%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	51% ± 13%	Explore
mononuclear phagocyte	7 studies	56% ± 20%	Explore
hematopoietic stem cell	7 studies	47% ± 15%	Explore
melanocyte	7 studies	70% ± 17%	Explore
CD4-positive helper T cell	6 studies	59% ± 20%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	41% ± 11%	Explore
hematopoietic precursor cell	6 studies	49% ± 25%	Explore
platelet	6 studies	28% ± 12%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	61% ± 7%	Explore
IgG plasma cell	6 studies	22% ± 4%	Explore
abnormal cell	6 studies	40% ± 18%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	66% ± 14%	Explore
CD4-positive, alpha-beta cytotoxic T cell	5 studies	43% ± 18%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	46% ± 11%	Explore
exhausted T cell	5 studies	57% ± 13%	Explore
plasmablast	5 studies	48% ± 19%	Explore
intestinal crypt stem cell	5 studies	26% ± 9%	Explore
IgA plasma cell	5 studies	25% ± 8%	Explore
lymphocyte	5 studies	53% ± 14%	Explore
T-helper 17 cell	5 studies	61% ± 20%	Explore
group 3 innate lymphoid cell	5 studies	76% ± 11%	Explore
adventitial cell	5 studies	32% ± 12%	Explore
inflammatory macrophage	5 studies	56% ± 18%	Explore
double negative thymocyte	5 studies	50% ± 19%	Explore
intermediate monocyte	5 studies	65% ± 21%	Explore
granulocyte	5 studies	67% ± 22%	Explore
goblet cell	5 studies	38% ± 22%	Explore
keratinocyte	5 studies	65% ± 19%	Explore
endothelial cell	4 studies	36% ± 15%	Explore
monocyte-derived dendritic cell	4 studies	69% ± 8%	Explore
transit amplifying cell	4 studies	38% ± 30%	Explore
ciliated cell	4 studies	22% ± 8%	Explore
glial cell	4 studies	21% ± 3%	Explore
Mueller cell	4 studies	27% ± 3%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	39% ± 9%	Explore
luminal cell of prostate epithelium	4 studies	40% ± 8%	Explore
Schwann cell	4 studies	45% ± 10%	Explore
T-helper 1 cell	4 studies	64% ± 13%	Explore
hillock cell	3 studies	60% ± 4%	Explore
common myeloid progenitor	3 studies	57% ± 18%	Explore
serous secreting cell	3 studies	36% ± 12%	Explore
tissue-resident macrophage	3 studies	50% ± 10%	Explore
acinar cell	3 studies	67% ± 24%	Explore
pancreatic ductal cell	3 studies	88% ± 4%	Explore
granulocyte monocyte progenitor cell	3 studies	36% ± 2%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	40% ± 13%	Explore
respiratory goblet cell	3 studies	25% ± 3%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	53% ± 5%	Explore
double-positive, alpha-beta thymocyte	3 studies	45% ± 21%	Explore
myoepithelial cell	3 studies	30% ± 5%	Explore
progenitor cell of mammary luminal epithelium	3 studies	26% ± 9%	Explore
mucus secreting cell	3 studies	31% ± 10%	Explore
erythrocyte	3 studies	33% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	22 studies	51% ± 18%	Explore
lung	20 studies	41% ± 14%	Explore
intestine	7 studies	27% ± 12%	Explore
lymph node	6 studies	38% ± 16%	Explore
bone marrow	5 studies	36% ± 18%	Explore
uterus	5 studies	35% ± 13%	Explore
adipose	5 studies	34% ± 11%	Explore
prostate	5 studies	38% ± 11%	Explore
breast	5 studies	35% ± 11%	Explore
esophagus	4 studies	31% ± 6%	Explore
liver	4 studies	36% ± 15%	Explore
skin	4 studies	59% ± 17%	Explore
brain	3 studies	28% ± 5%	Explore
kidney	3 studies	35% ± 13%	Explore
pancreas	3 studies	32% ± 11%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	100%	48074.09	1809 / 1809	98%	367.83	463 / 472
esophagus	100%	18308.00	1444 / 1445	96%	237.66	176 / 183
breast	100%	15855.40	458 / 459	96%	174.40	1075 / 1118
lung	99%	19835.17	575 / 578	94%	164.83	1086 / 1155
intestine	93%	10388.05	903 / 966	96%	116.03	504 / 527
pancreas	95%	20207.59	312 / 328	93%	118.10	166 / 178
uterus	98%	27527.04	167 / 170	88%	154.94	403 / 459
thymus	97%	10178.77	636 / 653	88%	163.67	533 / 605
bladder	100%	16327.00	21 / 21	81%	121.88	406 / 504
prostate	100%	13662.94	244 / 245	80%	60.85	401 / 502
stomach	54%	7120.14	194 / 359	93%	124.22	266 / 286
eye	0%	0	0 / 0	100%	831.10	80 / 80
lymph node	0%	0	0 / 0	100%	163.22	29 / 29
spleen	100%	10777.65	241 / 241	0%	0	0 / 0
peripheral blood	98%	29761.96	915 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	181.82	44 / 45
adipose	98%	19123.84	1177 / 1204	0%	0	0 / 0
blood vessel	97%	14850.16	1290 / 1335	0%	0	0 / 0
brain	14%	1296.93	370 / 2642	77%	115.51	543 / 705
kidney	31%	3211.20	28 / 89	56%	44.25	502 / 901
adrenal gland	21%	1270.60	55 / 258	60%	78.19	138 / 230
ovary	9%	681.32	16 / 180	22%	10.58	95 / 430
heart	21%	1453.22	177 / 861	0%	0	0 / 0
liver	1%	121.17	3 / 226	16%	13.46	63 / 406
muscle	6%	385.30	48 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0043154	Biological process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0019221	Biological process	cytokine-mediated signaling pathway
GO_0006954	Biological process	inflammatory response
GO_0007160	Biological process	cell-matrix adhesion
GO_0033138	Biological process	positive regulation of peptidyl-serine phosphorylation
GO_0007155	Biological process	cell adhesion
GO_0030214	Biological process	hyaluronan catabolic process
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0050731	Biological process	positive regulation of peptidyl-tyrosine phosphorylation
GO_0044319	Biological process	wound healing, spreading of cells
GO_1902166	Biological process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO_0034116	Biological process	positive regulation of heterotypic cell-cell adhesion
GO_1900625	Biological process	positive regulation of monocyte aggregation
GO_0070487	Biological process	monocyte aggregation
GO_0098609	Biological process	cell-cell adhesion
GO_0070374	Biological process	positive regulation of ERK1 and ERK2 cascade
GO_2000392	Biological process	regulation of lamellipodium morphogenesis
GO_0051216	Biological process	cartilage development
GO_0042110	Biological process	T cell activation
GO_0016477	Biological process	cell migration
GO_0044344	Biological process	cellular response to fibroblast growth factor stimulus
GO_0043518	Biological process	negative regulation of DNA damage response, signal transduction by p53 class mediator
GO_0005902	Cellular component	microvillus
GO_0016324	Cellular component	apical plasma membrane
GO_0030667	Cellular component	secretory granule membrane
GO_0035692	Cellular component	macrophage migration inhibitory factor receptor complex
GO_0005886	Cellular component	plasma membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005794	Cellular component	Golgi apparatus
GO_0005925	Cellular component	focal adhesion
GO_0009986	Cellular component	cell surface
GO_0031258	Cellular component	lamellipodium membrane
GO_0005829	Cellular component	cytosol
GO_0042995	Cellular component	cell projection
GO_0016323	Cellular component	basolateral plasma membrane
GO_0004888	Molecular function	transmembrane signaling receptor activity
GO_0004896	Molecular function	cytokine receptor activity
GO_0005515	Molecular function	protein binding
GO_0005518	Molecular function	collagen binding
GO_0005540	Molecular function	hyaluronic acid binding

IV. Literature review

[source]

Gene name	CD44
Protein name	CD44 protein Soluble CD44 CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44) CD44 epithelial domain CD44 molecule (Indian blood group) CD44 molecule CD44 antigen (Extracellular matrix receptor III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (Phagocytic glycoprotein I) Extracellular matrix receptor III
Synonyms	MIC4 MDU2 MDU3 LHR
Description	FUNCTION: Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment . Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection . Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases . Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion . .
Accessions	ENST00000525685.6 ENST00000525211.6 Q86UZ1 C1PHE6 ENST00000434472.6 [P16070-11] E9PKC6 ENST00000352818.8 [P16070-18] ENST00000533222.5 ENST00000428726.8 [P16070-1] ENST00000263398.11 [P16070-12] C1PHC3 H0YES0 C1PHC4 O95659 ENST00000525469.1 H0YE40 C0STK4 ENST00000526000.6 H0YCL4 ENST00000528672.1 J3KN83 Q99900 H0YD17 ENST00000531110.6 ENST00000531873.5 H0YEV3 ENST00000278386.10 [P16070-19] ENST00000279452.10 ENST00000425428.6 H0YD90 ENST00000278385.10 H0YDX6 ENST00000528455.5 ENST00000526553.6 ENST00000527889.6 H0YEU1 ENST00000525688.5 H0YDW7 O95658 ENST00000526025.2 Q9P2Z2 H0Y5E4 H0YDV8 ENST00000433892.6 [P16070-10] H0YF08 H0YEA1 ENST00000526669.6 H0YCV9 H0YD13 C1PHC2 H0Y2P0 ENST00000442151.6 A0A385KNS5 ENST00000415148.6 [P16070-4] A0A1Z1VXF2 P16070 ENST00000524922.1

CD44 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review