NRXN1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
astrocyte	16 studies	75% ± 26%	Explore
oligodendrocyte precursor cell	16 studies	83% ± 22%	Explore
glutamatergic neuron	12 studies	94% ± 10%	Explore
GABAergic neuron	11 studies	85% ± 18%	Explore
oligodendrocyte	11 studies	44% ± 22%	Explore
microglial cell	9 studies	47% ± 17%	Explore
neuron	8 studies	59% ± 19%	Explore
amacrine cell	8 studies	64% ± 18%	Explore
endothelial cell	7 studies	52% ± 21%	Explore
glial cell	7 studies	57% ± 25%	Explore
retinal ganglion cell	7 studies	80% ± 21%	Explore
interneuron	6 studies	85% ± 14%	Explore
Schwann cell	5 studies	81% ± 13%	Explore
granule cell	4 studies	86% ± 16%	Explore
OFF-bipolar cell	4 studies	56% ± 23%	Explore
retina horizontal cell	4 studies	49% ± 22%	Explore
macrophage	3 studies	35% ± 11%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	67% ± 13%	Explore
GABAergic interneuron	3 studies	84% ± 8%	Explore
retinal bipolar neuron	3 studies	40% ± 22%	Explore
GABAergic amacrine cell	3 studies	86% ± 14%	Explore
ON-bipolar cell	3 studies	56% ± 27%	Explore
glycinergic amacrine cell	3 studies	90% ± 10%	Explore
rod bipolar cell	3 studies	54% ± 22%	Explore
ependymal cell	3 studies	54% ± 28%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	17 studies	66% ± 24%	Explore
eye	5 studies	27% ± 17%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	98%	6937.65	2596 / 2642	98%	20.81	690 / 705
intestine	64%	1730.50	618 / 966	2%	0.05	10 / 527
esophagus	59%	1092.04	849 / 1445	4%	0.15	8 / 183
prostate	39%	535.52	95 / 245	7%	0.14	33 / 502
adrenal gland	2%	23.14	5 / 258	40%	1.85	93 / 230
bladder	33%	319.76	7 / 21	2%	0.13	12 / 504
heart	32%	385.78	277 / 861	0%	0	0 / 0
stomach	24%	387.41	86 / 359	3%	0.05	8 / 286
pancreas	0%	1.82	1 / 328	16%	0.53	29 / 178
tonsil	0%	0	0 / 0	16%	0.27	7 / 45
uterus	9%	94.36	15 / 170	5%	0.22	21 / 459
breast	7%	68.26	34 / 459	5%	0.22	61 / 1118
blood vessel	9%	122.57	117 / 1335	0%	0	0 / 0
lung	0%	1.16	1 / 578	7%	0.27	81 / 1155
skin	1%	10.45	25 / 1809	5%	0.94	22 / 472
adipose	4%	42.47	47 / 1204	0%	0	0 / 0
ovary	3%	34.38	5 / 180	0%	0.01	2 / 430
thymus	2%	13.00	10 / 653	1%	0.01	5 / 605
eye	0%	0	0 / 0	1%	0.02	1 / 80
kidney	0%	0	0 / 89	1%	0.03	6 / 901
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
liver	0%	0	0 / 226	0%	0	0 / 406
lymph node	0%	0	0 / 0	0%	0	0 / 29
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0097119	Biological process	postsynaptic density protein 95 clustering
GO_0001525	Biological process	angiogenesis
GO_0097104	Biological process	postsynaptic membrane assembly
GO_0042297	Biological process	vocal learning
GO_0010629	Biological process	negative regulation of gene expression
GO_0007612	Biological process	learning
GO_1905520	Biological process	positive regulation of presynaptic active zone assembly
GO_0045184	Biological process	establishment of protein localization
GO_0031175	Biological process	neuron projection development
GO_0007269	Biological process	neurotransmitter secretion
GO_0007165	Biological process	signal transduction
GO_0010628	Biological process	positive regulation of gene expression
GO_0033138	Biological process	positive regulation of peptidyl-serine phosphorylation
GO_0097120	Biological process	receptor localization to synapse
GO_2000310	Biological process	regulation of NMDA receptor activity
GO_0050885	Biological process	neuromuscular process controlling balance
GO_0097116	Biological process	gephyrin clustering involved in postsynaptic density assembly
GO_0097118	Biological process	neuroligin clustering involved in postsynaptic membrane assembly
GO_0097114	Biological process	NMDA glutamate receptor clustering
GO_2000463	Biological process	positive regulation of excitatory postsynaptic potential
GO_0071277	Biological process	cellular response to calcium ion
GO_0071625	Biological process	vocalization behavior
GO_1903078	Biological process	positive regulation of protein localization to plasma membrane
GO_0045743	Biological process	positive regulation of fibroblast growth factor receptor signaling pathway
GO_0010739	Biological process	positive regulation of protein kinase A signaling
GO_0007268	Biological process	chemical synaptic transmission
GO_0051490	Biological process	negative regulation of filopodium assembly
GO_2000311	Biological process	regulation of AMPA receptor activity
GO_0016339	Biological process	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
GO_0097112	Biological process	gamma-aminobutyric acid receptor clustering
GO_0023041	Biological process	neuronal signal transduction
GO_1900020	Biological process	positive regulation of protein kinase C activity
GO_0030534	Biological process	adult behavior
GO_0097091	Biological process	synaptic vesicle clustering
GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0051968	Biological process	positive regulation of synaptic transmission, glutamatergic
GO_0090129	Biological process	positive regulation of synapse maturation
GO_0097117	Biological process	guanylate kinase-associated protein clustering
GO_0021707	Biological process	cerebellar granule cell differentiation
GO_0007416	Biological process	synapse assembly
GO_0090126	Biological process	protein-containing complex assembly involved in synapse maturation
GO_0035418	Biological process	protein localization to synapse
GO_0035176	Biological process	social behavior
GO_0007158	Biological process	neuron cell-cell adhesion
GO_0051965	Biological process	positive regulation of synapse assembly
GO_0007157	Biological process	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO_0070374	Biological process	positive regulation of ERK1 and ERK2 cascade
GO_0097105	Biological process	presynaptic membrane assembly
GO_0007411	Biological process	axon guidance
GO_0005730	Cellular component	nucleolus
GO_0098793	Cellular component	presynapse
GO_0005886	Cellular component	plasma membrane
GO_0030139	Cellular component	endocytic vesicle
GO_0043025	Cellular component	neuronal cell body
GO_0042734	Cellular component	presynaptic membrane
GO_0009986	Cellular component	cell surface
GO_0005783	Cellular component	endoplasmic reticulum
GO_0044295	Cellular component	axonal growth cone
GO_0042995	Cellular component	cell projection
GO_0031965	Cellular component	nuclear membrane
GO_0031982	Cellular component	vesicle
GO_0038023	Molecular function	signaling receptor activity
GO_0004888	Molecular function	transmembrane signaling receptor activity
GO_0005246	Molecular function	calcium channel regulator activity
GO_0005102	Molecular function	signaling receptor binding
GO_0097109	Molecular function	neuroligin family protein binding
GO_0005105	Molecular function	type 1 fibroblast growth factor receptor binding
GO_0048306	Molecular function	calcium-dependent protein binding
GO_0046872	Molecular function	metal ion binding
GO_0050839	Molecular function	cell adhesion molecule binding
GO_0033130	Molecular function	acetylcholine receptor binding
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	NRXN1
Protein name	Neurexin-1-beta (Neurexin I-beta) Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha) NRXN1 protein Neurexin 1
Synonyms	KIAA0578
Description	FUNCTION: Neuronal cell surface protein involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. Plays a role in formation of synaptic junctions. . FUNCTION: Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may affect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom. .
Accessions	P58400 ENST00000630543.2 A0A0U1RR00 A0A0D9SG60 Q49A31 ENST00000406316.6 [Q9ULB1-1] ENST00000637906.1 E7ERL8 ENST00000401710.5 [P58400-2] A0A1B0GVF4 ENST00000625320.2 ENST00000626249.2 A4FVB9 A0A0D9SG96 ENST00000675235.1 A0A1B0GUR2 ENST00000405581.3 A0A1B0GUQ1 ENST00000635519.1 A0A1B0GTL0 A0A6Q8PFA2 H7BYC7 A0A0D9SFY6 A0A0D9SF36 ENST00000625891.2 A0A0U1RRK7 ENST00000496792.3 ENST00000630656.1 ENST00000628364.2 A0A0D9SEJ1 ENST00000495871.2 ENST00000636066.1 ENST00000638037.1 ENST00000637511.1 A0A0D9SF07 ENST00000331040.9 ENST00000404971.5 [Q9ULB1-3] A0A0D9SEQ7 Q9ULB1 A0A0D9SEM5 ENST00000412315.5 ENST00000401669.7 ENST00000405472.7 A0A0U1RQP8 Q08AH0 A0A0R4J2G7 A0A0D9SFF4 ENST00000625672.2 [Q9ULB1-2] E7EQN4 ENST00000378262.7 ENST00000627198.2 ENST00000342183.9 [P58400-1] ENST00000636345.1 ENST00000628515.2 H0Y568 A0A1B0GU94 ENST00000626899.1 A0A1D5RMU6

NRXN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review