TREM2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TREM2 at tissue level.

III. Associated gene sets

GO_1905581Biological processpositive regulation of low-density lipoprotein particle clearance
GO_0010468Biological processregulation of gene expression
GO_1904141Biological processpositive regulation of microglial cell migration
GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_0034136Biological processnegative regulation of toll-like receptor 2 signaling pathway
GO_0098657Biological processimport into cell
GO_0050829Biological processdefense response to Gram-negative bacterium
GO_0110089Biological processregulation of hippocampal neuron apoptotic process
GO_1900016Biological processnegative regulation of cytokine production involved in inflammatory response
GO_0002862Biological processnegative regulation of inflammatory response to antigenic stimulus
GO_0006911Biological processphagocytosis, engulfment
GO_0150079Biological processnegative regulation of neuroinflammatory response
GO_0006959Biological processhumoral immune response
GO_0038160Biological processCXCL12-activated CXCR4 signaling pathway
GO_0045672Biological processpositive regulation of osteoclast differentiation
GO_0050730Biological processregulation of peptidyl-tyrosine phosphorylation
GO_1900015Biological processregulation of cytokine production involved in inflammatory response
GO_0006910Biological processphagocytosis, recognition
GO_1900223Biological processpositive regulation of amyloid-beta clearance
GO_0050866Biological processnegative regulation of cell activation
GO_0007613Biological processmemory
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0055088Biological processlipid homeostasis
GO_0060100Biological processpositive regulation of phagocytosis, engulfment
GO_0032720Biological processnegative regulation of tumor necrosis factor production
GO_0035176Biological processsocial behavior
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0032006Biological processregulation of TOR signaling
GO_0032008Biological processpositive regulation of TOR signaling
GO_2001171Biological processpositive regulation of ATP biosynthetic process
GO_0120035Biological processregulation of plasma membrane bounded cell projection organization
GO_0045960Biological processpositive regulation of complement activation, classical pathway
GO_1903980Biological processpositive regulation of microglial cell activation
GO_0071333Biological processcellular response to glucose stimulus
GO_1901800Biological processpositive regulation of proteasomal protein catabolic process
GO_1903376Biological processregulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO_0002931Biological processresponse to ischemia
GO_0061518Biological processmicroglial cell proliferation
GO_0070345Biological processnegative regulation of fat cell proliferation
GO_1905808Biological processpositive regulation of synapse pruning
GO_0150062Biological processcomplement-mediated synapse pruning
GO_0048143Biological processastrocyte activation
GO_0010628Biological processpositive regulation of gene expression
GO_0032691Biological processnegative regulation of interleukin-1 beta production
GO_0034241Biological processpositive regulation of macrophage fusion
GO_0045088Biological processregulation of innate immune response
GO_0043277Biological processapoptotic cell clearance
GO_0071223Biological processcellular response to lipoteichoic acid
GO_0097062Biological processdendritic spine maintenance
GO_0002588Biological processpositive regulation of antigen processing and presentation of peptide antigen via MHC class II
GO_0034351Biological processnegative regulation of glial cell apoptotic process
GO_0032675Biological processregulation of interleukin-6 production
GO_0060075Biological processregulation of resting membrane potential
GO_0034151Biological processregulation of toll-like receptor 6 signaling pathway
GO_0043124Biological processnegative regulation of canonical NF-kappaB signal transduction
GO_0002282Biological processmicroglial cell activation involved in immune response
GO_1903082Biological processpositive regulation of C-C chemokine receptor CCR7 signaling pathway
GO_2000350Biological processpositive regulation of CD40 signaling pathway
GO_0001774Biological processmicroglial cell activation
GO_1905805Biological processexcitatory synapse pruning
GO_0030316Biological processosteoclast differentiation
GO_0050921Biological processpositive regulation of chemotaxis
GO_1900226Biological processnegative regulation of NLRP3 inflammasome complex assembly
GO_0010983Biological processpositive regulation of high-density lipoprotein particle clearance
GO_0045728Biological processrespiratory burst after phagocytosis
GO_0071224Biological processcellular response to peptidoglycan
GO_0019216Biological processregulation of lipid metabolic process
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0097028Biological processdendritic cell differentiation
GO_0010891Biological processnegative regulation of sequestering of triglyceride
GO_0050714Biological processpositive regulation of protein secretion
GO_0033674Biological processpositive regulation of kinase activity
GO_0150094Biological processamyloid-beta clearance by cellular catabolic process
GO_1905907Biological processnegative regulation of amyloid fibril formation
GO_0071640Biological processregulation of macrophage inflammatory protein 1 alpha production
GO_0032499Biological processdetection of peptidoglycan
GO_1904646Biological processcellular response to amyloid-beta
GO_0140052Biological processcellular response to oxidised low-density lipoprotein particle stimulus
GO_0050766Biological processpositive regulation of phagocytosis
GO_1904093Biological processnegative regulation of autophagic cell death
GO_0050850Biological processpositive regulation of calcium-mediated signaling
GO_0070392Biological processdetection of lipoteichoic acid
GO_0010887Biological processnegative regulation of cholesterol storage
GO_0061889Biological processnegative regulation of astrocyte activation
GO_0071396Biological processcellular response to lipid
GO_0048678Biological processresponse to axon injury
GO_0034144Biological processnegative regulation of toll-like receptor 4 signaling pathway
GO_0070269Biological processpyroptotic inflammatory response
GO_1901980Biological processpositive regulation of inward rectifier potassium channel activity
GO_0032733Biological processpositive regulation of interleukin-10 production
GO_1901076Biological processpositive regulation of engulfment of apoptotic cell
GO_0051898Biological processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_1904951Biological processpositive regulation of establishment of protein localization
GO_1903078Biological processpositive regulation of protein localization to plasma membrane
GO_0050731Biological processpositive regulation of peptidyl-tyrosine phosphorylation
GO_0010875Biological processpositive regulation of cholesterol efflux
GO_1902531Biological processregulation of intracellular signal transduction
GO_0010507Biological processnegative regulation of autophagy
GO_1902227Biological processnegative regulation of macrophage colony-stimulating factor signaling pathway
GO_0032497Biological processdetection of lipopolysaccharide
GO_1903753Biological processnegative regulation of p38MAPK cascade
GO_1905291Biological processpositive regulation of CAMKK-AMPK signaling cascade
GO_0071456Biological processcellular response to hypoxia
GO_0009986Cellular componentcell surface
GO_0044853Cellular componentplasma membrane raft
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0004888Molecular functiontransmembrane signaling receptor activity
GO_0071813Molecular functionlipoprotein particle binding
GO_0019209Molecular functionkinase activator activity
GO_0097110Molecular functionscaffold protein binding
GO_0034186Molecular functionapolipoprotein A-I binding
GO_0038023Molecular functionsignaling receptor activity
GO_0001540Molecular functionamyloid-beta binding
GO_0008289Molecular functionlipid binding
GO_0001786Molecular functionphosphatidylserine binding
GO_1990782Molecular functionprotein tyrosine kinase binding
GO_0034185Molecular functionapolipoprotein binding
GO_0030169Molecular functionlow-density lipoprotein particle binding
GO_0001530Molecular functionlipopolysaccharide binding
GO_0008035Molecular functionhigh-density lipoprotein particle binding
GO_0034189Molecular functionvery-low-density lipoprotein particle binding
GO_0005515Molecular functionprotein binding
GO_0070891Molecular functionlipoteichoic acid binding
GO_0120146Molecular functionsulfatide binding
GO_0042834Molecular functionpeptidoglycan binding
GO_0005543Molecular functionphospholipid binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0008013Molecular functionbeta-catenin binding
GO_0008429Molecular functionphosphatidylethanolamine binding

IV. Literature review

[source]
Gene nameTREM2
Protein nameTriggering receptor expressed on myeloid cells 2 (TREM-2) (Triggering receptor expressed on monocytes 2)
Triggering receptor expressed on myeloid cells 2
Synonyms
DescriptionFUNCTION: Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding . Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia . Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro-inflammatory cytokines, such as IL6R and CCL3, and the anti-inflammatory cytokine ARG1 (By similarity). Acts as a receptor for lipoprotein particles such as LDL, VLDL, and HDL and for apolipoproteins such as APOA1, APOA2, APOB, APOE, APOE2, APOE3, APOE4, and CLU and enhances their uptake in microglia . Binds phospholipids (preferably anionic lipids) such as phosphatidylserine, phosphatidylethanolamine, phosphatidylglycerol and sphingomyelin . Regulates microglial proliferation by acting as an upstream regulator of the Wnt/beta-catenin signaling cascade (By similarity). Required for microglial phagocytosis of apoptotic neurons . Also required for microglial activation and phagocytosis of myelin debris after neuronal injury and of neuronal synapses during synapse elimination in the developing brain (By similarity). Regulates microglial chemotaxis and process outgrowth, and also the microglial response to oxidative stress and lipopolysaccharide (By similarity). It suppresses PI3K and NF-kappa-B signaling in response to lipopolysaccharide; thus promoting phagocytosis, suppressing pro-inflammatory cytokine and nitric oxide production, inhibiting apoptosis and increasing expression of IL10 and TGFB (By similarity). During oxidative stress, it promotes anti-apoptotic NF-kappa-B signaling and ERK signaling (By similarity). Plays a role in microglial MTOR activation and metabolism (By similarity). Regulates age-related changes in microglial numbers . Triggers activation of the immune responses in macrophages and dendritic cells . Mediates cytokine-induced formation of multinucleated giant cells which are formed by the fusion of macrophages (By similarity). In dendritic cells, it mediates up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival . Involved in the positive regulation of osteoclast differentiation . .

AccessionsENST00000338469.3 [Q9NZC2-2]
Q9NZC2
ENST00000373113.8 [Q9NZC2-1]
Q5TCX1
E3WHI5
ENST00000373122.8 [Q9NZC2-3]