Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| peripheral blood | 10 studies | 20% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| kidney | 97% | 152.40 | 86 / 89 | 94% | 4.34 | 846 / 901 |
| lung | 99% | 230.11 | 570 / 578 | 90% | 3.83 | 1037 / 1155 |
| thymus | 97% | 157.19 | 636 / 653 | 86% | 4.79 | 518 / 605 |
| stomach | 69% | 78.88 | 248 / 359 | 81% | 3.16 | 231 / 286 |
| skin | 76% | 153.66 | 1375 / 1809 | 74% | 3.75 | 348 / 472 |
| intestine | 69% | 298.25 | 664 / 966 | 80% | 3.35 | 424 / 527 |
| breast | 71% | 63.89 | 324 / 459 | 70% | 2.33 | 780 / 1118 |
| bladder | 62% | 87.05 | 13 / 21 | 73% | 2.48 | 368 / 504 |
| esophagus | 56% | 108.86 | 805 / 1445 | 75% | 2.16 | 137 / 183 |
| liver | 81% | 82.93 | 183 / 226 | 44% | 1.01 | 179 / 406 |
| prostate | 84% | 83.47 | 205 / 245 | 36% | 0.73 | 180 / 502 |
| uterus | 46% | 32.05 | 78 / 170 | 69% | 2.44 | 317 / 459 |
| spleen | 100% | 1274.80 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 1.69 | 1 / 1 |
| peripheral blood | 100% | 2444.66 | 928 / 929 | 0% | 0 | 0 / 0 |
| pancreas | 18% | 9.87 | 59 / 328 | 81% | 2.53 | 145 / 178 |
| ovary | 14% | 8.61 | 25 / 180 | 80% | 2.64 | 344 / 430 |
| lymph node | 0% | 0 | 0 / 0 | 93% | 13.12 | 27 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 87% | 5.43 | 39 / 45 |
| adipose | 76% | 76.35 | 914 / 1204 | 0% | 0 | 0 / 0 |
| adrenal gland | 69% | 46.96 | 178 / 258 | 3% | 0.05 | 8 / 230 |
| eye | 0% | 0 | 0 / 0 | 70% | 1.64 | 56 / 80 |
| blood vessel | 47% | 40.82 | 627 / 1335 | 0% | 0 | 0 / 0 |
| brain | 24% | 14.60 | 639 / 2642 | 15% | 0.26 | 107 / 705 |
| heart | 12% | 7.32 | 102 / 861 | 0% | 0 | 0 / 0 |
| muscle | 2% | 0.97 | 16 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0033627 | Biological process | cell adhesion mediated by integrin |
| GO_0007160 | Biological process | cell-matrix adhesion |
| GO_0002387 | Biological process | immune response in gut-associated lymphoid tissue |
| GO_0007155 | Biological process | cell adhesion |
| GO_0034113 | Biological process | heterotypic cell-cell adhesion |
| GO_0043113 | Biological process | receptor clustering |
| GO_0046718 | Biological process | symbiont entry into host cell |
| GO_0007229 | Biological process | integrin-mediated signaling pathway |
| GO_0034446 | Biological process | substrate adhesion-dependent cell spreading |
| GO_0050900 | Biological process | leukocyte migration |
| GO_0050901 | Biological process | leukocyte tethering or rolling |
| GO_0003366 | Biological process | cell-matrix adhesion involved in ameboidal cell migration |
| GO_0072678 | Biological process | T cell migration |
| GO_0098609 | Biological process | cell-cell adhesion |
| GO_0043235 | Cellular component | receptor complex |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0008305 | Cellular component | integrin complex |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005925 | Cellular component | focal adhesion |
| GO_0009986 | Cellular component | cell surface |
| GO_0034669 | Cellular component | integrin alpha4-beta7 complex |
| GO_0001618 | Molecular function | virus receptor activity |
| GO_0005178 | Molecular function | integrin binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0050839 | Molecular function | cell adhesion molecule binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | ITGB7 |
| Protein name | Integrin beta Integrin b7 subunit Integrin beta-7 (Gut homing receptor beta subunit) Integrin subunit beta 7 |
| Synonyms | |
| Description | FUNCTION: Integrin ITGA4/ITGB7 (alpha-4/beta-7) (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT) (Probable). Integrin ITGA4/ITGB7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract . Interacts also with VCAM1 and fibronectin, an extracellular matrix component (Probable). It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin (Probable). Interactions involve the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin (Probable). Integrin ITGAE/ITGB7 (alpha-E/beta-7, HML-1) is a receptor for E-cadherin . .; FUNCTION: (Microbial infection) Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. . |
| Accessions | F8VNX4 P26010 A0A023IQJ1 ENST00000550743.6 [P26010-2] H3BRX4 F5H6T4 F8W186 ENST00000552972.5 ENST00000549086.2 A0A023IPD5 ENST00000552935.5 ENST00000267082.10 [P26010-1] ENST00000542497.5 H3BRM2 A0A023IP89 ENST00000551319.5 A0A023IQH3 ENST00000422257.7 [P26010-1] |
