ROCK1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	44 studies	34% ± 14%	Explore
macrophage	39 studies	37% ± 17%	Explore
B cell	38 studies	31% ± 10%	Explore
pericyte	36 studies	40% ± 13%	Explore
natural killer cell	35 studies	32% ± 9%	Explore
fibroblast	33 studies	29% ± 10%	Explore
CD8-positive, alpha-beta T cell	33 studies	29% ± 8%	Explore
smooth muscle cell	31 studies	40% ± 14%	Explore
CD4-positive, alpha-beta T cell	28 studies	27% ± 7%	Explore
conventional dendritic cell	27 studies	34% ± 15%	Explore
T cell	26 studies	30% ± 9%	Explore
classical monocyte	24 studies	40% ± 12%	Explore
regulatory T cell	24 studies	29% ± 7%	Explore
non-classical monocyte	21 studies	35% ± 12%	Explore
dendritic cell	19 studies	46% ± 21%	Explore
monocyte	19 studies	38% ± 16%	Explore
memory B cell	19 studies	29% ± 5%	Explore
naive B cell	19 studies	29% ± 7%	Explore
plasmacytoid dendritic cell	17 studies	31% ± 11%	Explore
mature NK T cell	17 studies	29% ± 7%	Explore
mast cell	16 studies	26% ± 10%	Explore
ciliated cell	16 studies	27% ± 10%	Explore
gamma-delta T cell	16 studies	35% ± 11%	Explore
microglial cell	16 studies	43% ± 15%	Explore
myeloid cell	16 studies	39% ± 15%	Explore
endothelial cell of lymphatic vessel	15 studies	31% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	35% ± 8%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	25% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	33% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	26% ± 8%	Explore
capillary endothelial cell	13 studies	25% ± 6%	Explore
myofibroblast cell	13 studies	30% ± 12%	Explore
mucosal invariant T cell	13 studies	28% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	33% ± 7%	Explore
oligodendrocyte precursor cell	12 studies	34% ± 15%	Explore
oligodendrocyte	12 studies	37% ± 14%	Explore
astrocyte	12 studies	35% ± 17%	Explore
epithelial cell	12 studies	36% ± 18%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	27% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	33% ± 9%	Explore
vein endothelial cell	11 studies	27% ± 13%	Explore
basal cell	11 studies	28% ± 14%	Explore
type I pneumocyte	10 studies	29% ± 8%	Explore
GABAergic neuron	10 studies	40% ± 20%	Explore
glutamatergic neuron	10 studies	45% ± 24%	Explore
endothelial cell of artery	10 studies	24% ± 3%	Explore
connective tissue cell	9 studies	29% ± 9%	Explore
endothelial cell of vascular tree	9 studies	33% ± 19%	Explore
alveolar macrophage	8 studies	41% ± 15%	Explore
leukocyte	8 studies	41% ± 12%	Explore
abnormal cell	8 studies	25% ± 9%	Explore
neuron	8 studies	41% ± 21%	Explore
adipocyte	8 studies	30% ± 10%	Explore
plasma cell	7 studies	27% ± 11%	Explore
neutrophil	7 studies	27% ± 5%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	26% ± 5%	Explore
mononuclear phagocyte	7 studies	40% ± 13%	Explore
precursor B cell	7 studies	43% ± 11%	Explore
type II pneumocyte	7 studies	26% ± 6%	Explore
retinal cone cell	7 studies	29% ± 10%	Explore
T follicular helper cell	7 studies	24% ± 3%	Explore
hematopoietic precursor cell	6 studies	37% ± 16%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	24% ± 7%	Explore
amacrine cell	6 studies	25% ± 5%	Explore
interneuron	6 studies	48% ± 20%	Explore
lymphocyte	6 studies	41% ± 12%	Explore
club cell	6 studies	30% ± 10%	Explore
retina horizontal cell	6 studies	25% ± 8%	Explore
retinal rod cell	6 studies	29% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	31% ± 10%	Explore
innate lymphoid cell	6 studies	28% ± 6%	Explore
retinal bipolar neuron	5 studies	24% ± 3%	Explore
hematopoietic stem cell	5 studies	31% ± 10%	Explore
pro-B cell	5 studies	45% ± 6%	Explore
brush cell	5 studies	28% ± 9%	Explore
immature B cell	5 studies	38% ± 7%	Explore
cardiac muscle cell	5 studies	22% ± 4%	Explore
mesothelial cell	5 studies	38% ± 13%	Explore
respiratory goblet cell	5 studies	29% ± 10%	Explore
goblet cell	5 studies	35% ± 23%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	28% ± 5%	Explore
exhausted T cell	4 studies	37% ± 13%	Explore
plasmablast	4 studies	44% ± 22%	Explore
glial cell	4 studies	30% ± 10%	Explore
granule cell	4 studies	30% ± 5%	Explore
progenitor cell	4 studies	29% ± 2%	Explore
Mueller cell	4 studies	23% ± 8%	Explore
secretory cell	4 studies	23% ± 5%	Explore
intermediate monocyte	4 studies	47% ± 23%	Explore
enteroendocrine cell	4 studies	33% ± 10%	Explore
type B pancreatic cell	3 studies	41% ± 24%	Explore
glomerular endothelial cell	3 studies	27% ± 4%	Explore
podocyte	3 studies	30% ± 9%	Explore
neural crest cell	3 studies	20% ± 3%	Explore
GABAergic interneuron	3 studies	31% ± 12%	Explore
tissue-resident macrophage	3 studies	36% ± 16%	Explore
GABAergic amacrine cell	3 studies	31% ± 7%	Explore
OFF-bipolar cell	3 studies	26% ± 8%	Explore
ON-bipolar cell	3 studies	27% ± 6%	Explore
glycinergic amacrine cell	3 studies	25% ± 2%	Explore
rod bipolar cell	3 studies	28% ± 7%	Explore
germinal center B cell	3 studies	31% ± 2%	Explore
CD4-positive helper T cell	3 studies	29% ± 6%	Explore
hepatocyte	3 studies	40% ± 21%	Explore
muscle cell	3 studies	58% ± 21%	Explore
pancreatic A cell	3 studies	38% ± 17%	Explore
ependymal cell	3 studies	33% ± 13%	Explore
granulocyte	3 studies	32% ± 15%	Explore
adventitial cell	3 studies	25% ± 5%	Explore
chondrocyte	3 studies	26% ± 6%	Explore
group 3 innate lymphoid cell	3 studies	41% ± 12%	Explore
transit amplifying cell	3 studies	37% ± 30%	Explore
T-helper 17 cell	3 studies	27% ± 3%	Explore
T-helper 1 cell	3 studies	24% ± 5%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	23% ± 3%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	22% ± 2%	Explore
double negative thymocyte	3 studies	43% ± 15%	Explore
mural cell	3 studies	51% ± 10%	Explore
mucus secreting cell	3 studies	25% ± 5%	Explore
erythrocyte	3 studies	24% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	19 studies	27% ± 9%	Explore
brain	17 studies	38% ± 19%	Explore
peripheral blood	16 studies	34% ± 12%	Explore
intestine	10 studies	20% ± 8%	Explore
eye	8 studies	30% ± 13%	Explore
kidney	6 studies	24% ± 6%	Explore
heart	5 studies	27% ± 6%	Explore
lymph node	5 studies	27% ± 4%	Explore
liver	5 studies	34% ± 9%	Explore
bone marrow	4 studies	32% ± 10%	Explore
uterus	4 studies	29% ± 9%	Explore
breast	4 studies	20% ± 5%	Explore
adipose	4 studies	35% ± 7%	Explore
placenta	3 studies	22% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	6810.12	1440 / 1445	100%	36.95	183 / 183
ovary	100%	4695.56	180 / 180	100%	12.75	428 / 430
lung	100%	6638.47	577 / 578	99%	20.87	1149 / 1155
breast	100%	5977.15	459 / 459	99%	26.06	1102 / 1118
thymus	100%	4152.46	652 / 653	98%	18.45	594 / 605
prostate	100%	4240.90	244 / 245	98%	20.02	494 / 502
stomach	99%	3837.20	357 / 359	96%	19.73	275 / 286
bladder	100%	6683.67	21 / 21	95%	14.86	480 / 504
uterus	100%	6213.70	170 / 170	95%	15.63	434 / 459
intestine	100%	5023.26	966 / 966	94%	15.84	495 / 527
kidney	99%	2771.33	88 / 89	94%	18.25	846 / 901
skin	100%	5107.89	1803 / 1809	89%	18.58	422 / 472
brain	89%	1853.20	2345 / 2642	99%	17.35	696 / 705
adrenal gland	100%	3217.87	258 / 258	86%	11.59	198 / 230
pancreas	84%	1499.90	274 / 328	99%	19.98	176 / 178
liver	91%	1703.96	206 / 226	82%	8.79	334 / 406
adipose	100%	7334.23	1204 / 1204	0%	0	0 / 0
blood vessel	100%	13880.00	1335 / 1335	0%	0	0 / 0
spleen	100%	4595.23	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	4.08	1 / 1
lymph node	0%	0	0 / 0	97%	24.65	28 / 29
tonsil	0%	0	0 / 0	96%	15.81	43 / 45
muscle	93%	1911.04	748 / 803	0%	0	0 / 0
heart	92%	2869.46	791 / 861	0%	0	0 / 0
peripheral blood	83%	4532.42	770 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	55%	5.45	44 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006939	Biological process	smooth muscle contraction
GO_0072659	Biological process	protein localization to plasma membrane
GO_1903347	Biological process	negative regulation of bicellular tight junction assembly
GO_0071559	Biological process	response to transforming growth factor beta
GO_0070168	Biological process	negative regulation of biomineral tissue development
GO_0030036	Biological process	actin cytoskeleton organization
GO_0010922	Biological process	positive regulation of phosphatase activity
GO_0051045	Biological process	negative regulation of membrane protein ectodomain proteolysis
GO_0030334	Biological process	regulation of cell migration
GO_0050900	Biological process	leukocyte migration
GO_1900223	Biological process	positive regulation of amyloid-beta clearance
GO_2000145	Biological process	regulation of cell motility
GO_2000672	Biological process	negative regulation of motor neuron apoptotic process
GO_0006468	Biological process	protein phosphorylation
GO_0032091	Biological process	negative regulation of protein binding
GO_0035509	Biological process	negative regulation of myosin-light-chain-phosphatase activity
GO_0031175	Biological process	neuron projection development
GO_0007165	Biological process	signal transduction
GO_0010628	Biological process	positive regulation of gene expression
GO_0035306	Biological process	positive regulation of dephosphorylation
GO_0000281	Biological process	mitotic cytokinesis
GO_0010508	Biological process	positive regulation of autophagy
GO_0090521	Biological process	podocyte cell migration
GO_0050901	Biological process	leukocyte tethering or rolling
GO_0070507	Biological process	regulation of microtubule cytoskeleton organization
GO_0090128	Biological process	regulation of synapse maturation
GO_1905205	Biological process	positive regulation of connective tissue replacement
GO_0007249	Biological process	canonical NF-kappaB signal transduction
GO_1902430	Biological process	negative regulation of amyloid-beta formation
GO_0018107	Biological process	peptidyl-threonine phosphorylation
GO_0003180	Biological process	aortic valve morphogenesis
GO_0061157	Biological process	mRNA destabilization
GO_0097746	Biological process	blood vessel diameter maintenance
GO_0031032	Biological process	actomyosin structure organization
GO_0048598	Biological process	embryonic morphogenesis
GO_1902992	Biological process	negative regulation of amyloid precursor protein catabolic process
GO_0140058	Biological process	neuron projection arborization
GO_0051492	Biological process	regulation of stress fiber assembly
GO_0051894	Biological process	positive regulation of focal adhesion assembly
GO_0051893	Biological process	regulation of focal adhesion assembly
GO_1903140	Biological process	regulation of establishment of endothelial barrier
GO_0045664	Biological process	regulation of neuron differentiation
GO_0022614	Biological process	membrane to membrane docking
GO_0018105	Biological process	peptidyl-serine phosphorylation
GO_0032060	Biological process	bleb assembly
GO_0001837	Biological process	epithelial to mesenchymal transition
GO_2000114	Biological process	regulation of establishment of cell polarity
GO_0110061	Biological process	regulation of angiotensin-activated signaling pathway
GO_1900242	Biological process	regulation of synaptic vesicle endocytosis
GO_0010613	Biological process	positive regulation of cardiac muscle hypertrophy
GO_1901888	Biological process	regulation of cell junction assembly
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_0045616	Biological process	regulation of keratinocyte differentiation
GO_0042326	Biological process	negative regulation of phosphorylation
GO_0016525	Biological process	negative regulation of angiogenesis
GO_0003383	Biological process	apical constriction
GO_0097049	Biological process	motor neuron apoptotic process
GO_0007266	Biological process	Rho protein signal transduction
GO_0051451	Biological process	myoblast migration
GO_0030155	Biological process	regulation of cell adhesion
GO_0030866	Biological process	cortical actin cytoskeleton organization
GO_0032956	Biological process	regulation of actin cytoskeleton organization
GO_1990776	Biological process	response to angiotensin
GO_0007159	Biological process	leukocyte cell-cell adhesion
GO_0005856	Cellular component	cytoskeleton
GO_0098685	Cellular component	Schaffer collateral - CA1 synapse
GO_0010494	Cellular component	cytoplasmic stress granule
GO_0001726	Cellular component	ruffle
GO_0005576	Cellular component	extracellular region
GO_0005814	Cellular component	centriole
GO_0030027	Cellular component	lamellipodium
GO_0005886	Cellular component	plasma membrane
GO_0032059	Cellular component	bleb
GO_0034774	Cellular component	secretory granule lumen
GO_0000139	Cellular component	Golgi membrane
GO_0005737	Cellular component	cytoplasm
GO_0005829	Cellular component	cytosol
GO_0004672	Molecular function	protein kinase activity
GO_0005524	Molecular function	ATP binding
GO_0048156	Molecular function	tau protein binding
GO_0106310	Molecular function	protein serine kinase activity
GO_0046872	Molecular function	metal ion binding
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0050321	Molecular function	tau-protein kinase activity
GO_0005515	Molecular function	protein binding
GO_0031267	Molecular function	small GTPase binding
GO_0072518	Molecular function	Rho-dependent protein serine/threonine kinase activity

IV. Literature review

[source]

Gene name	ROCK1
Protein name	non-specific serine/threonine protein kinase (EC 2.7.11.1) Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (p160 ROCK-1) Rho-associated protein kinase (EC 2.7.11.1) Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK)
Synonyms
Description	FUNCTION: Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity . Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A . Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing . Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress . Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation . Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation . Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation . Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). . FUNCTION: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. .
Accessions	D9ZGF8 Q49AA3 Q13464 A0A0U1RQV4 J3KRH6 ENST00000635540.2 ENST00000399799.3 ENST00000578051.1

ROCK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review