JAM2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045123Biological processcellular extravasation
GO_0031642Biological processnegative regulation of myelination
GO_2000403Biological processpositive regulation of lymphocyte migration
GO_0097241Biological processhematopoietic stem cell migration to bone marrow
GO_0035633Biological processmaintenance of blood-brain barrier
GO_0050901Biological processleukocyte tethering or rolling
GO_0071593Biological processlymphocyte aggregation
GO_0007520Biological processmyoblast fusion
GO_0098609Biological processcell-cell adhesion
GO_0007286Biological processspermatid development
GO_0007159Biological processleukocyte cell-cell adhesion
GO_0070160Cellular componenttight junction
GO_0005886Cellular componentplasma membrane
GO_0036477Cellular componentsomatodendritic compartment
GO_0044291Cellular componentcell-cell contact zone
GO_0009986Cellular componentcell surface
GO_0098636Cellular componentprotein complex involved in cell adhesion
GO_0005923Cellular componentbicellular tight junction
GO_0005178Molecular functionintegrin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameJAM2
Protein nameJunctional adhesion molecule B (JAM-B) (Junctional adhesion molecule 2) (JAM-2) (Vascular endothelial junction-associated molecule) (VE-JAM) (CD antigen CD322)
Junctional adhesion molecule 2
SynonymsUNQ219/PRO245
VEJAM
C21orf43
DescriptionFUNCTION: Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM3 to regulate different cellular processes . Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow . At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 . Plays a central role in leukocytes extravasation by facilitating not only transmigration but also tethering and rolling of leukocytes along the endothelium . Tethering and rolling of leukocytes are dependent on the binding by JAM2 of the integrin alpha-4/beta-1 . Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (By similarity). Also functions as an inhibitory somatodendritic cue that prevents the myelination of non-axonal parts of neurons (By similarity). During myogenesis, it is involved in myocyte fusion (By similarity). May also play a role in angiogenesis (By similarity). .

AccessionsENST00000312957.9 [P57087-2]
ENST00000480456.6 [P57087-1]
ENST00000460679.5
P57087
ENST00000400532.5 [P57087-3]
H0YEX9