MADCAM1 | OmnibusX

Name	Number of supported studies	Average coverage
vein endothelial cell	3 studies	58% ± 20%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of MADCAM1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	99%	247.19	2628 / 2642	84%	2.97	590 / 705
pancreas	91%	133.24	297 / 328	72%	5.80	129 / 178
stomach	94%	164.30	336 / 359	52%	2.17	150 / 286
adrenal gland	86%	58.39	223 / 258	59%	2.27	135 / 230
intestine	97%	466.72	938 / 966	48%	1.67	251 / 527
prostate	91%	69.61	224 / 245	35%	0.70	178 / 502
thymus	98%	169.72	637 / 653	24%	0.61	148 / 605
bladder	90%	55.29	19 / 21	25%	0.62	126 / 504
esophagus	78%	69.73	1120 / 1445	25%	0.74	46 / 183
breast	86%	87.32	397 / 459	14%	0.27	153 / 1118
spleen	100%	428.80	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	1.55	1 / 1
skin	73%	41.04	1322 / 1809	26%	0.46	122 / 472
ovary	79%	51.19	143 / 180	15%	0.25	63 / 430
liver	68%	40.22	153 / 226	24%	0.57	97 / 406
uterus	77%	48.77	131 / 170	13%	0.30	60 / 459
kidney	72%	41.47	64 / 89	18%	0.33	159 / 901
lung	61%	33.70	354 / 578	22%	0.79	252 / 1155
adipose	78%	61.37	937 / 1204	0%	0	0 / 0
peripheral blood	58%	40.01	537 / 929	0%	0	0 / 0
blood vessel	50%	27.29	664 / 1335	0%	0	0 / 0
muscle	47%	22.25	378 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	45%	5.43	13 / 29
heart	32%	13.58	279 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	9%	0.19	7 / 80
tonsil	0%	0	0 / 0	4%	0.06	2 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0007165	Biological process	signal transduction
GO_0006955	Biological process	immune response
GO_0050901	Biological process	leukocyte tethering or rolling
GO_0007229	Biological process	integrin-mediated signaling pathway
GO_0007155	Biological process	cell adhesion
GO_0034113	Biological process	heterotypic cell-cell adhesion
GO_2000403	Biological process	positive regulation of lymphocyte migration
GO_0043113	Biological process	receptor clustering
GO_0007160	Biological process	cell-matrix adhesion
GO_0002687	Biological process	positive regulation of leukocyte migration
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0098640	Molecular function	integrin binding involved in cell-matrix adhesion

Gene name	MADCAM1
Protein name	Mucosal addressin cell adhesion molecule 1 (MAdCAM-1) (hMAdCAM-1) MADCAM1 protein Mucosal vascular addressin cell adhesion molecule 1 Mucosal vascular addressin cell adhesion molecule 1 transcript variant 1
Synonyms
Description	FUNCTION: Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.
Accessions	ENST00000382683.8 [Q13477-4] U3KQ59 Q13477 ENST00000587541.5 ENST00000346144.8 [Q13477-3] B9EGE2 ENST00000215637.8 [Q13477-1] Q4PKD0 Q5PY60

MADCAM1 report