FFAR2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FFAR2 at tissue level.

III. Associated gene sets

GO_0032722Biological processpositive regulation of chemokine production
GO_0007200Biological processphospholipase C-activating G protein-coupled receptor signaling pathway
GO_0002752Biological processcell surface pattern recognition receptor signaling pathway
GO_0002385Biological processmucosal immune response
GO_0002720Biological processpositive regulation of cytokine production involved in immune response
GO_1990806Biological processligand-gated ion channel signaling pathway
GO_0046676Biological processnegative regulation of insulin secretion
GO_0032024Biological processpositive regulation of insulin secretion
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0002673Biological processregulation of acute inflammatory response
GO_0019915Biological processlipid storage
GO_0002879Biological processpositive regulation of acute inflammatory response to non-antigenic stimulus
GO_0090276Biological processregulation of peptide hormone secretion
GO_0032757Biological processpositive regulation of interleukin-8 production
GO_0002232Biological processleukocyte chemotaxis involved in inflammatory response
GO_0042593Biological processglucose homeostasis
GO_0045444Biological processfat cell differentiation
GO_0071398Biological processcellular response to fatty acid
GO_0005886Cellular componentplasma membrane
GO_0042995Cellular componentcell projection
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0008289Molecular functionlipid binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFFAR2
Protein nameFatty acid receptor 2
Free fatty acid receptor 2 (G-protein coupled receptor 43)
Free fatty acid receptor 2
SynonymsFFA2
GPR43
GPCR43
DescriptionFUNCTION: G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family . Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes . Among SCFAs, the fatty acids containing less than 6 carbons, the most potent activators are probably acetate, propionate and butyrate . Exhibits a SCFA-independent constitutive G protein-coupled receptor activity . .

AccessionsENST00000599180.3
A0A0C5K8I6
C6KYL4
O15552
ENST00000246549.2