Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| astrocyte | 15 studies | 42% ± 19% | |
| pericyte | 7 studies | 27% ± 9% | |
| hepatocyte | 6 studies | 59% ± 27% | |
| smooth muscle cell | 6 studies | 21% ± 6% | |
| fibroblast | 5 studies | 17% ± 2% | |
| epithelial cell of proximal tubule | 4 studies | 19% ± 2% | |
| cholangiocyte | 3 studies | 37% ± 15% | |
| epithelial cell | 3 studies | 27% ± 10% | |
| endothelial cell | 3 studies | 31% ± 12% | |
| abnormal cell | 3 studies | 41% ± 22% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| liver | 3 studies | 52% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 89621.52 | 226 / 226 | 99% | 3244.46 | 402 / 406 |
| brain | 100% | 13798.45 | 2630 / 2642 | 99% | 1006.30 | 695 / 705 |
| kidney | 67% | 4258.31 | 60 / 89 | 67% | 139.25 | 606 / 901 |
| heart | 99% | 9273.02 | 856 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 90% | 3657.06 | 1204 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 83% | 2272.18 | 663 / 803 | 0% | 0 | 0 / 0 |
| adrenal gland | 50% | 1099.55 | 128 / 258 | 20% | 22.88 | 46 / 230 |
| prostate | 40% | 1438.18 | 98 / 245 | 14% | 61.80 | 72 / 502 |
| thymus | 43% | 1042.34 | 281 / 653 | 1% | 1.17 | 8 / 605 |
| pancreas | 9% | 195.37 | 28 / 328 | 34% | 197.65 | 60 / 178 |
| stomach | 6% | 115.81 | 21 / 359 | 31% | 64.02 | 90 / 286 |
| intestine | 9% | 175.61 | 91 / 966 | 20% | 26.32 | 105 / 527 |
| breast | 7% | 151.17 | 34 / 459 | 14% | 25.48 | 160 / 1118 |
| esophagus | 8% | 145.92 | 113 / 1445 | 12% | 35.12 | 22 / 183 |
| adipose | 17% | 419.11 | 210 / 1204 | 0% | 0 | 0 / 0 |
| lung | 4% | 111.51 | 21 / 578 | 11% | 24.72 | 129 / 1155 |
| skin | 1% | 23.02 | 17 / 1809 | 13% | 19.94 | 60 / 472 |
| eye | 0% | 0 | 0 / 0 | 13% | 11.58 | 10 / 80 |
| uterus | 3% | 46.97 | 5 / 170 | 7% | 14.16 | 32 / 459 |
| ovary | 6% | 117.93 | 10 / 180 | 1% | 2.00 | 6 / 430 |
| bladder | 0% | 0 | 0 / 21 | 7% | 10.58 | 33 / 504 |
| spleen | 0% | 147.83 | 1 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 5.17 | 1 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0010744 | Biological process | positive regulation of macrophage derived foam cell differentiation |
| GO_0002016 | Biological process | regulation of blood volume by renin-angiotensin |
| GO_0010536 | Biological process | positive regulation of activation of Janus kinase activity |
| GO_0048146 | Biological process | positive regulation of fibroblast proliferation |
| GO_2001238 | Biological process | positive regulation of extrinsic apoptotic signaling pathway |
| GO_0001974 | Biological process | blood vessel remodeling |
| GO_0003014 | Biological process | renal system process |
| GO_0007200 | Biological process | phospholipase C-activating G protein-coupled receptor signaling pathway |
| GO_0051247 | Biological process | positive regulation of protein metabolic process |
| GO_0001558 | Biological process | regulation of cell growth |
| GO_0019229 | Biological process | regulation of vasoconstriction |
| GO_0038060 | Biological process | nitric oxide-cGMP-mediated signaling |
| GO_0010613 | Biological process | positive regulation of cardiac muscle hypertrophy |
| GO_0007199 | Biological process | G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger |
| GO_0035813 | Biological process | regulation of renal sodium excretion |
| GO_0010595 | Biological process | positive regulation of endothelial cell migration |
| GO_0008217 | Biological process | regulation of blood pressure |
| GO_0002019 | Biological process | regulation of renal output by angiotensin |
| GO_1990776 | Biological process | response to angiotensin |
| GO_0001822 | Biological process | kidney development |
| GO_0002034 | Biological process | maintenance of blood vessel diameter homeostasis by renin-angiotensin |
| GO_1901201 | Biological process | regulation of extracellular matrix assembly |
| GO_1905920 | Biological process | positive regulation of CoA-transferase activity |
| GO_0007267 | Biological process | cell-cell signaling |
| GO_0051092 | Biological process | positive regulation of NF-kappaB transcription factor activity |
| GO_1901203 | Biological process | positive regulation of extracellular matrix assembly |
| GO_1903598 | Biological process | positive regulation of gap junction assembly |
| GO_0034374 | Biological process | low-density lipoprotein particle remodeling |
| GO_0045742 | Biological process | positive regulation of epidermal growth factor receptor signaling pathway |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0042981 | Biological process | regulation of apoptotic process |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0038166 | Biological process | angiotensin-activated signaling pathway |
| GO_2000379 | Biological process | positive regulation of reactive oxygen species metabolic process |
| GO_1902895 | Biological process | positive regulation of miRNA transcription |
| GO_0002018 | Biological process | renin-angiotensin regulation of aldosterone production |
| GO_0090190 | Biological process | positive regulation of branching involved in ureteric bud morphogenesis |
| GO_0010718 | Biological process | positive regulation of epithelial to mesenchymal transition |
| GO_0043407 | Biological process | negative regulation of MAP kinase activity |
| GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_1903779 | Biological process | regulation of cardiac conduction |
| GO_0050729 | Biological process | positive regulation of inflammatory response |
| GO_0001819 | Biological process | positive regulation of cytokine production |
| GO_0042310 | Biological process | vasoconstriction |
| GO_0014873 | Biological process | response to muscle activity involved in regulation of muscle adaptation |
| GO_0051387 | Biological process | negative regulation of neurotrophin TRK receptor signaling pathway |
| GO_0042127 | Biological process | regulation of cell population proliferation |
| GO_0061098 | Biological process | positive regulation of protein tyrosine kinase activity |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0062023 | Cellular component | collagen-containing extracellular matrix |
| GO_0072562 | Cellular component | blood microparticle |
| GO_0005829 | Cellular component | cytosol |
| GO_0031702 | Molecular function | type 1 angiotensin receptor binding |
| GO_0004867 | Molecular function | serine-type endopeptidase inhibitor activity |
| GO_0031703 | Molecular function | type 2 angiotensin receptor binding |
| GO_0005179 | Molecular function | hormone activity |
| GO_0008083 | Molecular function | growth factor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | AGT |
| Protein name | Angiotensinogen Angiotensinogen (Serpin A8) [Cleaved into: Angiotensin-1 (Angiotensin 1-10) (Angiotensin I) (Ang I); Angiotensin-2 (Angiotensin 1-8) (Angiotensin II) (Ang II); Angiotensin-3 (Angiotensin 2-8) (Angiotensin III) (Ang III) (Des-Asp[1]-angiotensin II); Angiotensin-4 (Angiotensin 3-8) (Angiotensin IV) (Ang IV); Angiotensin 1-9; Angiotensin 1-7; Angiotensin 1-5; Angiotensin 1-4] Angiotensinogen (Serpin A8) Truncated angiotensinogen |
| Synonyms | hFLT1 SERPINA8 hCG_14741 |
| Description | FUNCTION: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. .; FUNCTION: [Angiotensin-2]: Acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone . Acts by binding to angiotensin receptors AGTR1 and AGTR2 . Also binds the DEAR/FBXW7-AS1 receptor (By similarity). .; FUNCTION: [Angiotensin-3]: Stimulates aldosterone release. .; FUNCTION: [Angiotensin 1-7]: Is a ligand for the G-protein coupled receptor MAS1 (By similarity). Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets (By similarity). . FUNCTION: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. .; FUNCTION: Stimulates aldosterone release. . FUNCTION: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. .; FUNCTION: Stimulates aldosterone release. . FUNCTION: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. .; FUNCTION: Stimulates aldosterone release. . FUNCTION: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. .; FUNCTION: Stimulates aldosterone release. . FUNCTION: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. .; FUNCTION: Stimulates aldosterone release. . FUNCTION: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. .; FUNCTION: Stimulates aldosterone release. . |
| Accessions | P01019 ENST00000679684.1 ENST00000680041 ENST00000679957.1 Q53YY1 A7L3A1 ENST00000679738.1 A7L3A2 ENST00000680041.1 A0A7P0TAP4 ENST00000681514 A0A7P0T9S6 A0A7P0T8D1 ENST00000681772.1 ENST00000681514.1 ENST00000366667.6 ENST00000680783.1 A0A7P0Z441 ENST00000679802.1 A7L3A3 ENST00000681269 ENST00000679738 ENST00000681269.1 A0A7P0TBH1 A7L3A5 A0A7P0TA52 A7L3A4 B0ZBE2 |
