GPR35 | OmnibusX

Name	Number of supported studies	Average coverage
dendritic cell	3 studies	26% ± 5%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of GPR35 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
intestine	100%	1754.10	966 / 966	98%	50.32	515 / 527
stomach	100%	733.92	358 / 359	98%	40.17	279 / 286
esophagus	99%	243.08	1428 / 1445	47%	13.81	86 / 183
pancreas	58%	71.11	190 / 328	84%	19.71	150 / 178
bladder	100%	243.14	21 / 21	39%	14.21	199 / 504
lung	100%	276.07	576 / 578	34%	5.49	395 / 1155
kidney	99%	371.03	88 / 89	34%	3.16	305 / 901
ovary	100%	449.43	180 / 180	25%	1.31	107 / 430
uterus	100%	433.64	170 / 170	25%	3.42	114 / 459
brain	98%	259.73	2586 / 2642	19%	0.77	134 / 705
thymus	99%	285.52	649 / 653	11%	0.61	64 / 605
prostate	100%	406.61	244 / 245	5%	0.24	24 / 502
breast	97%	222.85	444 / 459	6%	0.25	65 / 1118
spleen	100%	820.33	241 / 241	0%	0	0 / 0
peripheral blood	98%	449.97	914 / 929	0%	0	0 / 0
blood vessel	98%	197.95	1311 / 1335	0%	0	0 / 0
adipose	94%	161.53	1137 / 1204	0%	0	0 / 0
liver	57%	56.54	128 / 226	29%	3.94	119 / 406
heart	83%	123.58	714 / 861	0%	0	0 / 0
skin	74%	158.75	1331 / 1809	1%	0.06	7 / 472
muscle	63%	71.98	508 / 803	0%	0	0 / 0
adrenal gland	51%	49.40	132 / 258	1%	0.06	3 / 230
lymph node	0%	0	0 / 0	14%	0.62	4 / 29
tonsil	0%	0	0 / 0	11%	0.37	5 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_1901386	Biological process	negative regulation of voltage-gated calcium channel activity
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0070098	Biological process	chemokine-mediated signaling pathway
GO_0035025	Biological process	positive regulation of Rho protein signal transduction
GO_0007204	Biological process	positive regulation of cytosolic calcium ion concentration
GO_0007200	Biological process	phospholipase C-activating G protein-coupled receptor signaling pathway
GO_0007010	Biological process	cytoskeleton organization
GO_1904456	Biological process	negative regulation of neuronal action potential
GO_0005886	Cellular component	plasma membrane
GO_0016494	Molecular function	C-X-C chemokine receptor activity
GO_0004930	Molecular function	G protein-coupled receptor activity

Gene name	GPR35
Protein name	G-protein coupled receptor 35 (Kynurenic acid receptor) (KYNA receptor)
Synonyms
Description	FUNCTION: G-protein coupled receptor that binds to several ligands including the tryptophan metabolite kynurenic acid (KYNA), lysophosphatidic acid (LPA) or 5-hydroxyindoleacetic acid (5-HIAA) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways . Plays a role in neutrophil recruitment to sites of inflammation and bacterial clearance through the major serotonin metabolite 5-HIAA that acts as a physiological ligand . Stimulates lipid metabolism, thermogenic, and anti-inflammatory gene expression in adipose tissue once activated by kynurenic acid (By similarity). In macrophages, activation by lysophosphatidic acid promotes GPR35-induced signaling with a distinct transcriptional profile characterized by TNF production associated with ERK and NF-kappa-B activation. In turn, induces chemotaxis of macrophages (By similarity). .
Accessions	ENST00000407714.2 [Q9HC97-1] ENST00000438013.3 [Q9HC97-1] Q9HC97 ENST00000319838.10 [Q9HC97-1] ENST00000403859.1 [Q9HC97-1] ENST00000430267.2 [Q9HC97-2]

GPR35 report