CCKBR report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CCKBR at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CCKBR at tissue level.

III. Associated gene sets

GO_0008284Biological processpositive regulation of cell population proliferation
GO_0001696Biological processgastric acid secretion
GO_0007204Biological processpositive regulation of cytosolic calcium ion concentration
GO_0007200Biological processphospholipase C-activating G protein-coupled receptor signaling pathway
GO_0048732Biological processgland development
GO_0045851Biological processpH reduction
GO_0038188Biological processcholecystokinin signaling pathway
GO_0048565Biological processdigestive tract development
GO_0007166Biological processcell surface receptor signaling pathway
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005886Cellular componentplasma membrane
GO_0015054Molecular functiongastrin receptor activity
GO_0004951Molecular functioncholecystokinin receptor activity
GO_0017046Molecular functionpeptide hormone binding
GO_0031741Molecular functiontype B gastrin/cholecystokinin receptor binding
GO_0005515Molecular functionprotein binding
GO_0046935Molecular function1-phosphatidylinositol-3-kinase regulator activity

IV. Literature review

[source]
Gene nameCCKBR
Protein nameGastrin/cholecystokinin type B receptor (CCK-B receptor) (CCK-BR) (Cholecystokinin-2 receptor) (CCK2-R)
Cholecystokinin B receptor splice variant long isoform
Cholecystokinin B receptor
Cholecystokinin B receptor splice variant hip/hop2
Cholecystokinin B receptor splice variant hip/hop1
Cholecystokinin B receptor splice variant hip/hop3
Gastrin/cholecystokinin type B receptor (Cholecystokinin-2 receptor)
SynonymsCCKRB
DescriptionFUNCTION: Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.; FUNCTION: Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.

FUNCTION: Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. .

FUNCTION: Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. .

AccessionsA0SEH4
ENST00000525014.1
ENST00000525462.1 [P32239-2]
E9PJ49
A0SEH5
A0SEH6
A0SEH7
ENST00000531712.5
ENST00000532715.5
E9PPL7
P32239
ENST00000334619.7 [P32239-1]
E9PIC8