MC3R report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MC3R at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MC3R at tissue level.

III. Associated gene sets

GO_0008217Biological processregulation of blood pressure
GO_0055078Biological processsodium ion homeostasis
GO_0032922Biological processcircadian regulation of gene expression
GO_0060259Biological processregulation of feeding behavior
GO_0002027Biological processregulation of heart rate
GO_0007200Biological processphospholipase C-activating G protein-coupled receptor signaling pathway
GO_0042309Biological processhomoiothermy
GO_0019222Biological processregulation of metabolic process
GO_0045475Biological processlocomotor rhythm
GO_0007189Biological processadenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0007187Biological processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0042923Molecular functionneuropeptide binding
GO_0004977Molecular functionmelanocortin receptor activity
GO_0017046Molecular functionpeptide hormone binding
GO_0004980Molecular functionmelanocyte-stimulating hormone receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMC3R
Protein nameMelanocortin receptor 3 (MC3-R)
Synonyms
DescriptionFUNCTION: Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain. .

AccessionsP41968
ENST00000243911.2