EDNRB | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
pericyte	21 studies	36% ± 21%	Explore
astrocyte	19 studies	36% ± 16%	Explore
endothelial cell	17 studies	25% ± 11%	Explore
endothelial cell of lymphatic vessel	17 studies	32% ± 11%	Explore
smooth muscle cell	13 studies	33% ± 14%	Explore
fibroblast	12 studies	27% ± 10%	Explore
capillary endothelial cell	10 studies	28% ± 8%	Explore
myofibroblast cell	4 studies	24% ± 10%	Explore
endothelial cell of vascular tree	4 studies	21% ± 2%	Explore
oligodendrocyte precursor cell	4 studies	34% ± 19%	Explore
melanocyte	4 studies	55% ± 26%	Explore
connective tissue cell	3 studies	21% ± 3%	Explore
glial cell	3 studies	41% ± 25%	Explore
type II pneumocyte	3 studies	20% ± 3%	Explore
Mueller cell	3 studies	28% ± 3%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of EDNRB at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	92%	4636.64	2442 / 2642	99%	215.04	695 / 705
kidney	96%	3795.02	85 / 89	79%	82.43	714 / 901
skin	70%	1456.81	1258 / 1809	98%	381.04	461 / 472
thymus	100%	4918.80	651 / 653	60%	24.94	363 / 605
adrenal gland	100%	4223.41	257 / 258	57%	27.11	131 / 230
prostate	96%	3339.54	235 / 245	25%	6.48	126 / 502
lung	100%	8289.62	576 / 578	14%	3.60	156 / 1155
breast	100%	7206.51	459 / 459	12%	2.66	133 / 1118
bladder	100%	2839.76	21 / 21	8%	2.36	41 / 504
liver	81%	1565.93	184 / 226	25%	5.84	101 / 406
adipose	100%	9740.63	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	99%	204.99	79 / 80
heart	97%	3325.40	832 / 861	0%	0	0 / 0
intestine	87%	1794.17	837 / 966	9%	1.94	47 / 527
uterus	88%	2211.20	149 / 170	5%	1.32	25 / 459
spleen	84%	1741.13	202 / 241	0%	0	0 / 0
stomach	64%	1051.72	228 / 359	16%	3.60	45 / 286
esophagus	63%	1432.12	913 / 1445	15%	4.15	27 / 183
pancreas	51%	702.75	166 / 328	22%	6.35	40 / 178
blood vessel	59%	1229.54	789 / 1335	0%	0	0 / 0
muscle	56%	923.02	447 / 803	0%	0	0 / 0
ovary	28%	539.57	50 / 180	4%	1.62	19 / 430
peripheral blood	2%	22.12	15 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0007194	Biological process	negative regulation of adenylate cyclase activity
GO_0019934	Biological process	cGMP-mediated signaling
GO_0070294	Biological process	renal sodium ion absorption
GO_0030202	Biological process	heparin metabolic process
GO_1990839	Biological process	response to endothelin
GO_0072112	Biological process	podocyte differentiation
GO_0060406	Biological process	positive regulation of penile erection
GO_0007200	Biological process	phospholipase C-activating G protein-coupled receptor signaling pathway
GO_0019722	Biological process	calcium-mediated signaling
GO_0001755	Biological process	neural crest cell migration
GO_0014043	Biological process	negative regulation of neuron maturation
GO_0032341	Biological process	aldosterone metabolic process
GO_0014070	Biological process	response to organic cyclic compound
GO_0035812	Biological process	renal sodium excretion
GO_0002027	Biological process	regulation of heart rate
GO_0001934	Biological process	positive regulation of protein phosphorylation
GO_0006885	Biological process	regulation of pH
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_1904383	Biological process	response to sodium phosphate
GO_0060070	Biological process	canonical Wnt signaling pathway
GO_0042045	Biological process	epithelial fluid transport
GO_0051248	Biological process	negative regulation of protein metabolic process
GO_0097018	Biological process	renal albumin absorption
GO_0048066	Biological process	developmental pigmentation
GO_0030318	Biological process	melanocyte differentiation
GO_0048265	Biological process	response to pain
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0002001	Biological process	renin secretion into blood stream
GO_0007204	Biological process	positive regulation of cytosolic calcium ion concentration
GO_0050678	Biological process	regulation of epithelial cell proliferation
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_0007422	Biological process	peripheral nervous system development
GO_0160093	Biological process	chordate pharynx development
GO_0071222	Biological process	cellular response to lipopolysaccharide
GO_0031620	Biological process	regulation of fever generation
GO_0035645	Biological process	enteric smooth muscle cell differentiation
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0086100	Biological process	endothelin receptor signaling pathway
GO_0061028	Biological process	establishment of endothelial barrier
GO_0010467	Biological process	gene expression
GO_0048246	Biological process	macrophage chemotaxis
GO_0042311	Biological process	vasodilation
GO_0042310	Biological process	vasoconstriction
GO_0014826	Biological process	vein smooth muscle contraction
GO_0007399	Biological process	nervous system development
GO_0035810	Biological process	positive regulation of urine volume
GO_0097402	Biological process	neuroblast migration
GO_0070588	Biological process	calcium ion transmembrane transport
GO_0048484	Biological process	enteric nervous system development
GO_0007497	Biological process	posterior midgut development
GO_0071806	Biological process	protein transmembrane transport
GO_0007166	Biological process	cell surface receptor signaling pathway
GO_0005886	Cellular component	plasma membrane
GO_0031965	Cellular component	nuclear membrane
GO_0031702	Molecular function	type 1 angiotensin receptor binding
GO_0017046	Molecular function	peptide hormone binding
GO_0004962	Molecular function	endothelin receptor activity
GO_0005515	Molecular function	protein binding

Gene name	EDNRB
Protein name	Endothelin receptor type B (ET-B) (ET-BR) (Endothelin receptor non-selective type) Endothelin receptor type B (Endothelin receptor non-selective type)
Synonyms	ETRB
Description	FUNCTION: Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. .
Accessions	ENST00000626030.1 [P24530-2] ENST00000646605.1 [P24530-1] ENST00000377211.8 [P24530-3] ENST00000645696.1 A0A2R8YGF7 ENST00000646948.1 [P24530-1] ENST00000643890.1 ENST00000475537.2 [P24530-1] A0A2R8Y748 ENST00000646607.2 [P24530-1] P24530

EDNRB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review