F2RL1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of F2RL1 at tissue level.

III. Associated gene sets

GO_0032722Biological processpositive regulation of chemokine production
GO_0046328Biological processregulation of JNK cascade
GO_0006954Biological processinflammatory response
GO_0007200Biological processphospholipase C-activating G protein-coupled receptor signaling pathway
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0043547Biological processpositive regulation of GTPase activity
GO_0050921Biological processpositive regulation of chemotaxis
GO_0045087Biological processinnate immune response
GO_0002720Biological processpositive regulation of cytokine production involved in immune response
GO_0003104Biological processpositive regulation of glomerular filtration
GO_0046330Biological processpositive regulation of JNK cascade
GO_0051607Biological processdefense response to virus
GO_2000341Biological processregulation of chemokine (C-X-C motif) ligand 2 production
GO_0097029Biological processmature conventional dendritic cell differentiation
GO_0070493Biological processthrombin-activated receptor signaling pathway
GO_0032733Biological processpositive regulation of interleukin-10 production
GO_0007596Biological processblood coagulation
GO_0043311Biological processpositive regulation of eosinophil degranulation
GO_0046676Biological processnegative regulation of insulin secretion
GO_0034137Biological processpositive regulation of toll-like receptor 2 signaling pathway
GO_0030193Biological processregulation of blood coagulation
GO_0032731Biological processpositive regulation of interleukin-1 beta production
GO_0045217Biological processcell-cell junction maintenance
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0034145Biological processpositive regulation of toll-like receptor 4 signaling pathway
GO_0070661Biological processleukocyte proliferation
GO_0030335Biological processpositive regulation of cell migration
GO_0007204Biological processpositive regulation of cytosolic calcium ion concentration
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_1900135Biological processpositive regulation of renin secretion into blood stream
GO_0050900Biological processleukocyte migration
GO_0034140Biological processnegative regulation of toll-like receptor 3 signaling pathway
GO_0046329Biological processnegative regulation of JNK cascade
GO_0032757Biological processpositive regulation of interleukin-8 production
GO_0070963Biological processpositive regulation of neutrophil mediated killing of gram-negative bacterium
GO_0032682Biological processnegative regulation of chemokine production
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0032930Biological processpositive regulation of superoxide anion generation
GO_0061028Biological processestablishment of endothelial barrier
GO_0032729Biological processpositive regulation of type II interferon production
GO_0030836Biological processpositive regulation of actin filament depolymerization
GO_0099109Biological processpotassium channel activating, G protein-coupled receptor signaling pathway
GO_0031274Biological processpositive regulation of pseudopodium assembly
GO_0043122Biological processregulation of canonical NF-kappaB signal transduction
GO_0035025Biological processpositive regulation of Rho protein signal transduction
GO_0050927Biological processpositive regulation of positive chemotaxis
GO_0042311Biological processvasodilation
GO_0060100Biological processpositive regulation of phagocytosis, engulfment
GO_0010804Biological processnegative regulation of tumor necrosis factor-mediated signaling pathway
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0034141Biological processpositive regulation of toll-like receptor 3 signaling pathway
GO_0002690Biological processpositive regulation of leukocyte chemotaxis
GO_0042119Biological processneutrophil activation
GO_0002286Biological processT cell activation involved in immune response
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005886Cellular componentplasma membrane
GO_0005769Cellular componentearly endosome
GO_0005794Cellular componentGolgi apparatus
GO_0031143Cellular componentpseudopodium
GO_0038023Molecular functionsignaling receptor activity
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0031681Molecular functionG-protein beta-subunit binding
GO_0001965Molecular functionG-protein alpha-subunit binding
GO_0005102Molecular functionsignaling receptor binding
GO_0002020Molecular functionprotease binding
GO_0015057Molecular functionthrombin-activated receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameF2RL1
Protein nameProteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1) [Cleaved into: Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate cleaved 2]
F2R like trypsin receptor 1
SynonymsGPR11
PAR2
DescriptionFUNCTION: Receptor for trypsin and trypsin-like enzymes coupled to G proteins . Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho . Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Regulates endothelial cell barrier integrity during neutrophil extravasation, probably following proteolytic cleavage by PRTN3 . Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion . Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as GNAQ, GNA11, GNA14, GNA12 and GNA13, but probably not with G(o)-alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. However, according to PubMed:21627585 can signal through G(i) subunit alpha. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to GNAQ and GNA11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at 'Ser-536'; the function involves IKBKB and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of GNAQ and GNA11 and involves promotion of cofilin dephosphorylation and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as pro-inflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Implicated in a number of acute and chronic inflammatory diseases such as of the joints, lungs, brain, gastrointestinal tract, periodontium, skin, and vascular systems, and in autoimmune disorders. .

AccessionsP55085
ENST00000514165.1
ENST00000296677.5
D6RJH3