GRPR report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GRPR at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GRPR at tissue level.

III. Associated gene sets

GO_0043207Biological processresponse to external biotic stimulus
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0007218Biological processneuropeptide signaling pathway
GO_2000987Biological processpositive regulation of behavioral fear response
GO_0007200Biological processphospholipase C-activating G protein-coupled receptor signaling pathway
GO_0035176Biological processsocial behavior
GO_1903942Biological processpositive regulation of respiratory gaseous exchange
GO_0036343Biological processpsychomotor behavior
GO_0042127Biological processregulation of cell population proliferation
GO_0007611Biological processlearning or memory
GO_0061744Biological processmotor behavior
GO_0005886Cellular componentplasma membrane
GO_0008528Molecular functionG protein-coupled peptide receptor activity
GO_0042923Molecular functionneuropeptide binding
GO_0008188Molecular functionneuropeptide receptor activity

IV. Literature review

[source]
Gene nameGRPR
Protein nameGastrin-releasing peptide receptor isoform A
Gastrin-releasing peptide receptor (GRP-R) (GRP-preferring bombesin receptor)
Synonyms
DescriptionFUNCTION: Receptor for gastrin-releasing peptide (GRP) . Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (By similarity). In another study, shown to contribute to disinhibition of glutamatergic cells in the auditory cortex via signaling on vasoactive intestinal peptide-expressing cells which leads to enhanced auditory fear memories (By similarity). Contributes to the induction of sighing through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity). .

AccessionsP30550
ENST00000380289.3
X5D7H2