GPR32 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GPR32 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GPR32 at tissue level.

III. Associated gene sets

GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0007204Biological processpositive regulation of cytosolic calcium ion concentration
GO_0006954Biological processinflammatory response
GO_0007200Biological processphospholipase C-activating G protein-coupled receptor signaling pathway
GO_0002430Biological processcomplement receptor mediated signaling pathway
GO_0005886Cellular componentplasma membrane
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0004982Molecular functionN-formyl peptide receptor activity
GO_0004875Molecular functioncomplement receptor activity

IV. Literature review

[source]
Gene nameGPR32
Protein nameProbable G-protein coupled receptor 32
G protein-coupled receptor 32
SynonymshCG_1733560
DescriptionFUNCTION: G-protein coupled receptor that binds to several ligands including resolvin D1 (RvD1) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. In macrophages, enhances the RvD1-stimulated phagocytic and clearance functions . Macrophages migrate less toward different chemoattractant stimuli but phagocytose more microbial particles . Prevents the increase in Ca(2+) and activation of ERK1/2 used by histamine and its H1 receptor subtype to induce goblet cell secretion by activating PKC and GRK2 to counter-regulate the histamine receptor . .

AccessionsO75388
H9NIL6
ENST00000270590.4