AGTR1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of AGTR1 at tissue level.

III. Associated gene sets

GO_0010744Biological processpositive regulation of macrophage derived foam cell differentiation
GO_0060326Biological processcell chemotaxis
GO_0006954Biological processinflammatory response
GO_0007200Biological processphospholipase C-activating G protein-coupled receptor signaling pathway
GO_0051247Biological processpositive regulation of protein metabolic process
GO_0001558Biological processregulation of cell growth
GO_0019722Biological processcalcium-mediated signaling
GO_0019229Biological processregulation of vasoconstriction
GO_0035813Biological processregulation of renal sodium excretion
GO_0003081Biological processregulation of systemic arterial blood pressure by renin-angiotensin
GO_0001822Biological processkidney development
GO_0002034Biological processmaintenance of blood vessel diameter homeostasis by renin-angiotensin
GO_0086097Biological processphospholipase C-activating angiotensin-activated signaling pathway
GO_0050727Biological processregulation of inflammatory response
GO_1905920Biological processpositive regulation of CoA-transferase activity
GO_0097746Biological processblood vessel diameter maintenance
GO_0032430Biological processpositive regulation of phospholipase A2 activity
GO_0046718Biological processsymbiont entry into host cell
GO_0034374Biological processlow-density lipoprotein particle remodeling
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0007204Biological processpositive regulation of cytosolic calcium ion concentration
GO_0038166Biological processangiotensin-activated signaling pathway
GO_2000379Biological processpositive regulation of reactive oxygen species metabolic process
GO_0002018Biological processrenin-angiotensin regulation of aldosterone production
GO_0007266Biological processRho protein signal transduction
GO_0050729Biological processpositive regulation of inflammatory response
GO_1903589Biological processpositive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO_0042127Biological processregulation of cell population proliferation
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0031711Molecular functionbradykinin receptor binding
GO_0001596Molecular functionangiotensin type I receptor activity
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding
GO_0004945Molecular functionangiotensin type II receptor activity

IV. Literature review

[source]
Gene nameAGTR1
Protein nameType-1 angiotensin II receptor
Type-1 angiotensin II receptor (AT1AR) (AT1BR) (Angiotensin II type-1 receptor) (AT1 receptor)
SynonymsAT2R1
AT2R1B
AGTR1A
hCG_2022206
AGTR1B
DescriptionFUNCTION: Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney . The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C . .; FUNCTION: (Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, it is able to recognize and internalize the complex formed by secreted ACE2 and SARS-CoV-2 spike protein through DNM2/dynamin 2-dependent endocytosis. .

FUNCTION: Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C. .

FUNCTION: Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C. .

FUNCTION: Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C. .

FUNCTION: Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C. .

AccessionsQ53YY0
D3DNG8
P30556
ENST00000475347.5
ENST00000474935.5
ENST00000418473.7
ENST00000404754.2
ENST00000497524.5
A0A0A0MSE3
ENST00000402260
ENST00000349243.8
Q6NUP5
ENST00000402260.2
ENST00000418473
ENST00000461609.1