KISS1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of KISS1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KISS1 at tissue level.

III. Associated gene sets

GO_0060124Biological processpositive regulation of growth hormone secretion
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0050806Biological processpositive regulation of synaptic transmission
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0007204Biological processpositive regulation of cytosolic calcium ion concentration
GO_0007200Biological processphospholipase C-activating G protein-coupled receptor signaling pathway
GO_0007010Biological processcytoskeleton organization
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0060112Biological processgeneration of ovulation cycle rhythm
GO_0033686Biological processpositive regulation of luteinizing hormone secretion
GO_0016324Cellular componentapical plasma membrane
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0043025Cellular componentneuronal cell body
GO_0031773Molecular functionkisspeptin receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKISS1
Protein nameMetastasis-suppressor KiSS-1 (Kisspeptin-1) [Cleaved into: Metastin (Kisspeptin-54); Kisspeptin-14; Kisspeptin-13; Kisspeptin-10]
SynonymsPP5098
DescriptionFUNCTION: Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. .

AccessionsQ15726
ENST00000367194.5