GPR174 | OmnibusX

Name	Number of supported studies	Average coverage
CD8-positive, alpha-beta T cell	9 studies	22% ± 6%	Explore
gamma-delta T cell	6 studies	20% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	20% ± 5%	Explore
natural killer cell	5 studies	17% ± 1%	Explore
CD16-negative, CD56-bright natural killer cell, human	4 studies	17% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	20% ± 4%	Explore
regulatory T cell	4 studies	19% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	17% ± 2%	Explore
mature NK T cell	3 studies	16% ± 1%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	19% ± 2%	Explore
T follicular helper cell	3 studies	17% ± 1%	Explore
T cell	3 studies	18% ± 1%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of GPR174 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	98%	109.70	568 / 578	65%	2.42	755 / 1155
thymus	87%	62.20	570 / 653	36%	3.03	220 / 605
breast	60%	23.67	275 / 459	58%	2.51	651 / 1118
stomach	70%	23.35	253 / 359	48%	1.70	136 / 286
kidney	55%	32.71	49 / 89	53%	2.30	481 / 901
spleen	100%	260.94	241 / 241	0%	0	0 / 0
uterus	58%	15.61	99 / 170	41%	1.31	190 / 459
prostate	73%	28.87	180 / 245	25%	0.60	126 / 502
intestine	61%	68.75	591 / 966	35%	1.27	187 / 527
lymph node	0%	0	0 / 0	97%	15.83	28 / 29
peripheral blood	86%	231.84	803 / 929	0%	0	0 / 0
liver	70%	20.47	158 / 226	16%	0.50	66 / 406
esophagus	43%	9.71	615 / 1445	40%	1.75	73 / 183
bladder	52%	26.71	11 / 21	29%	0.87	148 / 504
skin	24%	4.71	436 / 1809	49%	3.05	231 / 472
tonsil	0%	0	0 / 0	71%	3.38	32 / 45
adipose	70%	31.69	837 / 1204	0%	0	0 / 0
pancreas	19%	3.18	63 / 328	48%	1.57	85 / 178
ovary	29%	6.41	53 / 180	21%	0.57	92 / 430
blood vessel	35%	11.94	464 / 1335	0%	0	0 / 0
heart	26%	5.95	228 / 861	0%	0	0 / 0
adrenal gland	20%	3.01	51 / 258	4%	0.08	9 / 230
eye	0%	0	0 / 0	11%	0.35	9 / 80
brain	4%	0.78	117 / 2642	4%	0.15	28 / 705
muscle	5%	0.69	40 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0043029	Biological process	T cell homeostasis
GO_0035025	Biological process	positive regulation of Rho protein signal transduction
GO_0007200	Biological process	phospholipase C-activating G protein-coupled receptor signaling pathway
GO_0032703	Biological process	negative regulation of interleukin-2 production
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0005886	Cellular component	plasma membrane
GO_0034451	Cellular component	centriolar satellite
GO_0045125	Molecular function	bioactive lipid receptor activity
GO_0004930	Molecular function	G protein-coupled receptor activity

Gene name	GPR174
Protein name	Probable G-protein coupled receptor 174
Synonyms	FKSG79 GPCR17
Description	FUNCTION: G-protein-coupled receptor of lysophosphatidylserine (LysoPS) that plays different roles in immune response . Plays a negative role in regulatory T-cell accumulation and homeostasis. Under inflammatory conditions where LysoPS production increases, contributes to the down-regulation of regulatory T-cell activity to favor effector response. Mediates the suppression of IL-2 production in activated T-lymphocytes leading to inhibition of growth, proliferation and differentiation of T-cells. Mechanistically, acts via G(12)/G(13)-containing heterotrimeric G proteins to trigger elevated cyclic AMP levels and protein kinase A/PKA activity, which may in turn act to antagonize proximal TCR signaling. Plays an important role in the initial period of sepsis through the regulation of macrophage polarization and pro- and anti-inflammatory cytokine secretions. Upon testosterone treatment, acts as a receptor for CCL21 and subsequently triggers through G(q)-alpha and G(12)/G(13) proteins a calcium flux leading to chemotactic effects on activated B-cells. Signals via GNA13 and PKA to promote CD86 up-regulation by follicular B-cells. .
Accessions	ENST00000645147.2 Q9BXC1

GPR174 report