Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| plasmacytoid dendritic cell | 10 studies | 23% ± 8% | |
| dendritic cell | 4 studies | 28% ± 9% | |
| macrophage | 4 studies | 18% ± 1% | |
| conventional dendritic cell | 4 studies | 19% ± 4% | |
| myeloid cell | 3 studies | 19% ± 3% | |
| microglial cell | 3 studies | 21% ± 4% |
Insufficient scRNA-seq data for expression of P2RY6 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 98% | 229.94 | 566 / 578 | 93% | 13.61 | 1075 / 1155 |
| kidney | 100% | 517.67 | 89 / 89 | 76% | 5.18 | 682 / 901 |
| thymus | 100% | 436.55 | 652 / 653 | 75% | 5.78 | 456 / 605 |
| esophagus | 88% | 141.67 | 1276 / 1445 | 84% | 8.42 | 153 / 183 |
| breast | 89% | 108.81 | 408 / 459 | 82% | 5.93 | 920 / 1118 |
| stomach | 84% | 104.93 | 303 / 359 | 85% | 6.47 | 243 / 286 |
| intestine | 96% | 164.87 | 930 / 966 | 71% | 4.69 | 376 / 527 |
| bladder | 86% | 128.62 | 18 / 21 | 74% | 9.51 | 373 / 504 |
| pancreas | 54% | 58.19 | 176 / 328 | 87% | 6.57 | 155 / 178 |
| uterus | 60% | 52.39 | 102 / 170 | 78% | 8.21 | 356 / 459 |
| ovary | 26% | 17.84 | 47 / 180 | 91% | 10.34 | 391 / 430 |
| skin | 44% | 29.30 | 797 / 1809 | 71% | 4.57 | 336 / 472 |
| adrenal gland | 94% | 118.30 | 242 / 258 | 17% | 0.97 | 39 / 230 |
| prostate | 92% | 154.76 | 226 / 245 | 18% | 0.56 | 89 / 502 |
| spleen | 100% | 2846.39 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 11.70 | 1 / 1 |
| blood vessel | 98% | 343.43 | 1307 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 93% | 9.24 | 27 / 29 |
| adipose | 91% | 161.67 | 1099 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 90% | 138.67 | 722 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 84% | 5.28 | 38 / 45 |
| heart | 83% | 121.88 | 715 / 861 | 0% | 0 | 0 / 0 |
| brain | 42% | 44.29 | 1108 / 2642 | 39% | 2.04 | 272 / 705 |
| liver | 34% | 29.06 | 77 / 226 | 28% | 1.81 | 115 / 406 |
| peripheral blood | 40% | 33.53 | 368 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 24% | 1.03 | 19 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0071380 | Biological process | cellular response to prostaglandin E stimulus |
| GO_0007200 | Biological process | phospholipase C-activating G protein-coupled receptor signaling pathway |
| GO_0014911 | Biological process | positive regulation of smooth muscle cell migration |
| GO_0031587 | Biological process | positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity |
| GO_0071415 | Biological process | cellular response to purine-containing compound |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0035589 | Biological process | G protein-coupled purinergic nucleotide receptor signaling pathway |
| GO_0030321 | Biological process | transepithelial chloride transport |
| GO_0032962 | Biological process | positive regulation of inositol trisphosphate biosynthetic process |
| GO_0006909 | Biological process | phagocytosis |
| GO_1905835 | Biological process | cellular response to pyrimidine ribonucleotide |
| GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
| GO_1904707 | Biological process | positive regulation of vascular associated smooth muscle cell proliferation |
| GO_0016324 | Cellular component | apical plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016323 | Cellular component | basolateral plasma membrane |
| GO_0004930 | Molecular function | G protein-coupled receptor activity |
| GO_0045029 | Molecular function | G protein-coupled UDP receptor activity |
| GO_0001621 | Molecular function | G protein-coupled ADP receptor activity |
| GO_0045030 | Molecular function | G protein-coupled UTP receptor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | P2RY6 |
| Protein name | Pyrimidinergic receptor P2Y6 P2Y purinoceptor 6 P2Y purinoceptor 6 (P2Y6) |
| Synonyms | PP2891 |
| Description | FUNCTION: Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. |
| Accessions | ENST00000538328.2 F5GYF3 ENST00000535931.2 ENST00000542092.5 ENST00000393590.3 ENST00000680825.1 ENST00000349767.6 ENST00000680955.1 ENST00000540342.6 F5GX90 ENST00000540124.6 ENST00000544437 ENST00000535931 F5H7H9 ENST00000618468.5 ENST00000679753.1 ENST00000393591.5 ENST00000536225.2 Q15077 A0A7P0TA46 ENST00000393592.7 ENST00000544437.6 |
