FFAR4 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FFAR4 at tissue level.

III. Associated gene sets

GO_0050873Biological processbrown fat cell differentiation
GO_0006954Biological processinflammatory response
GO_0007200Biological processphospholipase C-activating G protein-coupled receptor signaling pathway
GO_0070094Biological processpositive regulation of glucagon secretion
GO_0090275Biological processnegative regulation of somatostatin secretion
GO_0032870Biological processcellular response to hormone stimulus
GO_0045669Biological processpositive regulation of osteoblast differentiation
GO_0032691Biological processnegative regulation of interleukin-1 beta production
GO_0036321Biological processghrelin secretion
GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0050728Biological processnegative regulation of inflammatory response
GO_0043066Biological processnegative regulation of apoptotic process
GO_0007204Biological processpositive regulation of cytosolic calcium ion concentration
GO_0090336Biological processpositive regulation of brown fat cell differentiation
GO_0046879Biological processhormone secretion
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0007189Biological processadenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0001818Biological processnegative regulation of cytokine production
GO_0050912Biological processdetection of chemical stimulus involved in sensory perception of taste
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0050872Biological processwhite fat cell differentiation
GO_0010827Biological processregulation of glucose transmembrane transport
GO_0005886Cellular componentplasma membrane
GO_0030139Cellular componentendocytic vesicle
GO_0060170Cellular componentciliary membrane
GO_0005929Cellular componentcilium
GO_0010008Cellular componentendosome membrane
GO_0005765Cellular componentlysosomal membrane
GO_0004930Molecular functionG protein-coupled receptor activity
GO_0008527Molecular functiontaste receptor activity
GO_0042277Molecular functionpeptide binding
GO_0005504Molecular functionfatty acid binding

IV. Literature review

[source]
Gene nameFFAR4
Protein nameFree fatty acid receptor 4
Free fatty acid receptor 4 (G-protein coupled receptor 120) (G-protein coupled receptor 129) (G-protein coupled receptor GT01) (G-protein coupled receptor PGR4) (Omega-3 fatty acid receptor 1)
SynonymsPGR4
O3FAR1
GPR120
GPR129
DescriptionFUNCTION: [Isoform 2]: G-protein-coupled receptor for long-chain fatty acids (LCFAs) with a major role in adipogenesis, energy metabolism and inflammation. Signals via G-protein and beta-arrestin pathways . LCFAs sensing initiates activation of phosphoinositidase C-linked G proteins GNAQ and GNA11 (G(q)/G(11)), inducing a variety of cellular responses via second messenger pathways such as intracellular calcium mobilization, modulation of cyclic adenosine monophosphate (cAMP) production, and mitogen-activated protein kinases (MAPKs) . After LCFAs binding, associates with beta-arrestin ARRB2 that acts as an adapter protein coupling the receptor to specific downstream signaling pathways, as well as mediating receptor endocytosis . In response to dietary fats, plays an important role in the regulation of adipocyte proliferation and differentiation (By similarity). Acts as a receptor for omega-3 polyunsaturated fatty acids (PUFAs) at primary cilium of perivascular preadipocytes, initiating an adipogenic program via cAMP and CTCF-dependent chromatin remodeling that ultimately results in transcriptional activation of adipogenic genes and cell cycle entry (By similarity). Induces differentiation of brown adipocytes probably via autocrine and endocrine functions of FGF21 hormone (By similarity). Activates brown adipocytes by initiating intracellular calcium signaling that leads to mitochondrial depolarization and fission, and overall increased mitochondrial respiration (By similarity). Consequently stimulates fatty acid uptake and oxidation in mitochondria together with UCP1-mediated thermogenic respiration, eventually reducing fat mass (By similarity). Regulates bi-potential differentiation of bone marrow mesenchymal stem cells toward osteoblasts or adipocytes likely by up-regulating distinct integrins (By similarity). In response to dietary fats regulates hormone secretion and appetite (By similarity). Stimulates GIP and GLP1 secretion from enteroendocrine cells as well as GCG secretion in pancreatic alpha cells, thereby playing a role in the regulation of blood glucose levels (By similarity). Negatively regulates glucose-induced SST secretion in pancreatic delta cells (By similarity). Mediates LCFAs inhibition of GHRL secretion, an appetite-controlling hormone (By similarity). In taste buds, contributes to sensing of dietary fatty acids by the gustatory system (By similarity). During the inflammatory response, promotes anti-inflammatory M2 macrophage differentiation in adipose tissue (By similarity). Mediates the anti-inflammatory effects of omega-3 PUFAs via inhibition of NLRP3 inflammasome activation . In this pathway, interacts with adapter protein ARRB2 and inhibits the priming step triggered by Toll-like receptors (TLRs) at the level of TAK1 and TAB1 (By similarity). Further inhibits the activation step when ARRB2 directly associates with NLRP3, leading to inhibition of pro-inflammatory cytokine release . Mediates LCFAs anti-apoptotic effects (By similarity). .; FUNCTION: [Isoform 1]: Receptor for LCFAs decoupled from G-protein signaling. May signal through beta-arrestin pathway. After LCFAs binding, associates with beta-arrestin ARRB2 that may act as an adapter protein coupling the receptor to specific downstream signaling pathways, as well as mediating receptor endocytosis. .

AccessionsENST00000371481.9 [Q5NUL3-2]
Q5NUL3
ENST00000371483.8 [Q5NUL3-1]
S4R3L2
ENST00000604414.1