NMBR report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NMBR at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NMBR at tissue level.

III. Associated gene sets

GO_0007186Biological processG protein-coupled receptor signaling pathway
GO_0007218Biological processneuropeptide signaling pathway
GO_0007200Biological processphospholipase C-activating G protein-coupled receptor signaling pathway
GO_0160023Biological processsneeze reflex
GO_0032727Biological processpositive regulation of interferon-alpha production
GO_0140374Biological processantiviral innate immune response
GO_1903942Biological processpositive regulation of respiratory gaseous exchange
GO_0090290Biological processpositive regulation of osteoclast proliferation
GO_0032715Biological processnegative regulation of interleukin-6 production
GO_0031989Biological processbombesin receptor signaling pathway
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0008188Molecular functionneuropeptide receptor activity
GO_0004946Molecular functionbombesin receptor activity

IV. Literature review

[source]
Gene nameNMBR
Protein nameNeuromedin B receptor
Neuromedin-B receptor (NMB-R) (Epididymis tissue protein Li 185a) (Neuromedin-B-preferring bombesin receptor)
Synonyms
DescriptionFUNCTION: Receptor for neuromedin-B . Contributes to the maintenance of basal sigh rate through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity). Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (By similarity). These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response (By similarity). Contributes to induction of acute itch, possibly through its activation on dorsal root ganglion neurons by the NMB peptide (By similarity). Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 . Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (By similarity). .

AccessionsQ4VBL0
ENST00000258042.2
P28336