HCRT report

I. Expression across cell types

Insufficient scRNA-seq data for expression of HCRT at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HCRT at tissue level.

III. Associated gene sets

GO_0007218Biological processneuropeptide signaling pathway
GO_0007200Biological processphospholipase C-activating G protein-coupled receptor signaling pathway
GO_0030431Biological processsleep
GO_0060079Biological processexcitatory postsynaptic potential
GO_0051970Biological processnegative regulation of transmission of nerve impulse
GO_0051971Biological processpositive regulation of transmission of nerve impulse
GO_0046928Biological processregulation of neurotransmitter secretion
GO_0042594Biological processresponse to starvation
GO_0007204Biological processpositive regulation of cytosolic calcium ion concentration
GO_0008156Biological processnegative regulation of DNA replication
GO_0007268Biological processchemical synaptic transmission
GO_0042755Biological processeating behavior
GO_0043267Biological processnegative regulation of potassium ion transport
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0051928Biological processpositive regulation of calcium ion transport
GO_0001659Biological processtemperature homeostasis
GO_0007205Biological processprotein kinase C-activating G protein-coupled receptor signaling pathway
GO_0005576Cellular componentextracellular region
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0098794Cellular componentpostsynapse
GO_0008021Cellular componentsynaptic vesicle
GO_0030141Cellular componentsecretory granule
GO_0005791Cellular componentrough endoplasmic reticulum
GO_0031771Molecular functiontype 1 orexin receptor binding
GO_0031772Molecular functiontype 2 orexin receptor binding
GO_0005184Molecular functionneuropeptide hormone activity

IV. Literature review

[source]
Gene nameHCRT
Protein nameHypocretin neuropeptide precursor (Hypocretin) (Hcrt) (Orexin precursor) (Prepro-orexin) (Preprohypocretin) [Cleaved into: Orexin-A (Hypocretin-1) (Hcrt1); Orexin-B (Hypocretin-2) (Hcrt2)]
SynonymsPPOX
PPORX
OX
DescriptionFUNCTION: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. .; FUNCTION: [Orexin-A]: Binds to orexin receptors HCRTR1/OX1R and HCRTR2/OX2R with a high affinity (By similarity). Stimulates food intake (By similarity). Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (By similarity). .; FUNCTION: [Orexin-B]: Binds to orexin receptor HCRTR2/OX2R only (By similarity). Stimulates food intake (By similarity). Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (By similarity). .

AccessionsO43612
ENST00000293330.1